PubMed Health⌕ Search

Biomedical subjects

I N Shakirova

Publications and source records attributed to I N Shakirova.

4 recordsLinked to original sources
PubMed2001

Biochemical parameters in the diagnosis and monitoring of neurotoxicity of antitumor cytostatics.

The significance of neurospecific proteins in the diagnosis of neurotoxicity in patients with breast, lung, testicular, and ovarian cancer treated by taxane and cisplatin drugs was evaluated. The most pronounced increase in the content of these proteins and titers of autoantibodies to these proteins was observed in patients with clinical manifestations of neurotoxicity induced by cytostatics. A strong correlation was found between the concentration of myelin basic protein and cumulative dose of the drug (R=0.922; p<0.0001). These data suggest that myelin basic protein and gliofibrillar acid protein can be used as markers in the diagnosis and monitoring of antitumor drug neurotoxicity.

Antineoplastic Agents↗
PubMed1986

[Immunologic methods for assessing neurotoxic and neuro-radiation effects in acute human radiation sickness].

A study was made of a possibility to use immunological methods (the leucocyte migration inhibition test, leukergia reaction, the test of the cold fixation of the complement with cerebral antigen) for the assessment of neurotoxic and neuroradiation effects in total therapeutic irradiation of man at a dose of 10 Gy with preceding polychemotherapy. A rapid development of agranulocytosis made cellular reactions impossible. The above effects could be assessed using humoral specific immunological reactions. A possible role of anticerebral antibodies in the pathogenesis of neurological disorders was discussed.

Acute Disease↗