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Biomedical subjects

I N Witt

Publications and source records attributed to I N Witt.

11 recordsLinked to original sources
PubMed1987

Dental anomalies in familial adenomatous polyposis coli.

Forty-seven Danish and 50 Finnish patients with familial adenomatous polyposis coli (FPC) were studied by panoramic tomography (PTG) of the mandible, which showed dental abnormalities in 17% of the cases. Eleven patients (11%) had supernumerary teeth and/or compound osteomas, and nine patients (9%) had impacted permanent teeth. The frequency of the dental anomalies was statistically significantly higher in FPC patients than in the normal population; it is therefore concluded that this dental abnormality should be included in the list of extracolonic manifestations that may occur in any FPC patient. The frequency of dental anomalies was higher in Finnish than in Danish patients, probably owing to a higher frequency of extracolonic manifestations in the Finnish series.

Adenomatous Polyposis Coli↗
PubMed1986

Mandibular osteomas in ulcerative colitis.

Orthopantomography of the mandible in 50 consecutive patients with ulcerative colitis showed mandibular osteomas in 2 patients (4%), which is the same frequency as found in the normal population. Since earlier investigations have shown an increased frequency of mandibular osteomas in familial polyposis coli, the cancer family syndrome, and colorectal cancer without known familial disposition, it is concluded that the etiology of colorectal carcinoma in ulcerative colitis is not, as for these diseases, a combination of the same genetic and environmental factors but probably only a function of the duration and involvement of the disease.

Adolescent↗
PubMed1986

Mandibular osteomas in colorectal adenomas.

Orthopantomography of the mandible was carried out on 50 patients with colorectal adenoma(s) without carcinoma or any known familial disposition. Four patients (8%) had osteomas, and we advance the hypothesis that individuals with both osteomas and adenomas represent a separate type of adenoma patient. Further studies are needed to evaluate the prognostic value of the association of adenomas and mandibular osteomas.

Adenoma↗
PubMed1986

Mandibular osteomas in unaffected sibs and children of patients with familial polyposis coli.

Orthopantomography of the mandible (OTM) showed osteomas in 3 of 34 non-affected sibs and children of the probands in 14 families with polyposis coli. The observed to expected ratio with osteomas was 0.35, which is not significantly lower than 1.0 and in accordance with the frequency in the normal population. Although the result does not enable a definite evaluation of the diagnostic value of OTM, the finding suggests that this method may be used as a supplement to regular proctosigmoidoscopic screening of first-degree relatives of polyposis patients.

Adenoma↗
PubMed1985

Mandibular osteomas in colorectal cancer.

Orthopantomography of the mandible was carried out on 50 patients with colorectal cancer without known familial disposition. Twelve patients (24%) had osteomas, as against 5% in the control group (P less than 0.001). Since an increased occurrence of mandibular osteomas has earlier been demonstrated in cases of familial polyposis coli and the family cancer syndrome, we must conclude that genetic factors are presumably of more importance in the development of colorectal cancer than previously assumed.

Adult↗