Biomedical subjects

I Nimmo-Smith

Publications and source records attributed to I Nimmo-Smith.

At least 19 recordsLinked to original sources

PubMed2005

A diagnostic test of unawareness of bilateral motor task abilities in anosognosia for hemiplegia.

Anosognosia for hemiplegia (AHP) is conventionally defined/diagnosed by generic questions about awareness of limb plegia. However, unawareness of inability to perform tasks requiring bilateral use of limbs is more widespread and outlasts generic unawareness of plegia. Some patients consistently overestimate bilateral task ability. Our aim was to assess how well specific questions about bilateral task ability predict whether patients consistently overestimate their abilities. Six statistical indices were calculated to rank the questions for predictiveness of consistency of overestimation of bilateral task ability. Overall, bimanual questions are better predictors than bipedal questions of consistent overestimation. Three bimanual and two bipedal questions had both sensitivity and specificity above 80%. On the basis of accuracy and discriminability, one bimanual and one bipedal question that performed maximally could be used for a quick bedside heuristic index. For a more thorough diagnostic, especially for research, five bimanual and two bipedal questions were good predictors, and should be used. For both purposes, such tests should be given in combination with conventional generic questions assessing awareness of limb plegia, since the two kinds of question reflect different kinds of unawareness of motor incapacity.

Agnosia↗

PubMed2004

Hypofrontality in schizophrenia: a meta-analysis of functional imaging studies.

OBJECTIVE: Hypofrontality is not a well-replicated finding in schizophrenia either at rest or under conditions of task activation. METHOD: Studies comparing whole brain and frontal blood flow/metabolism in schizophrenic patients and normal controls were pooled. Voxel-based studies were also combined to examine the pattern of prefrontal activation in schizophrenia. RESULTS: Whole brain flow/metabolism was reduced in schizophrenia to only a small extent. Resting and activation frontal flow/metabolism were both reduced with a medium effect size. Duration of illness significantly moderated resting hypofrontality, but the moderating effects of neuroleptic treatment were consistent with an influence on global flow/metabolism only. Pooling of voxel-based studies did not suggest an abnormal pattern of activation in schizophrenia. CONCLUSION: Meta-analysis supports resting hypofrontality in schizophrenia. Task-activated hypofrontality is also supported, but there is little from voxel-based studies to suggest that this is associated with an altered pattern of regional functional architecture.

Frontal Lobe↗

PubMed2001

The differential assessment of children's attention: the Test of Everyday Attention for Children (TEA-Ch), normative sample and ADHD performance.

"Attention" is not a unitary brain process. Evidence from adult studies indicates that distinct neuroanatomical networks perform specific attentional operations and that these are vulnerable to selective damage. Accordingly, characterising attentional disorders requires the use of a variety of tasks that differentially challenge these systems. Here we describe a novel battery, the Test of Everyday Attention for Children (TEA-Ch), comprising nine subtests adapted from the adult literature. The performance of 293 healthy children between the ages of 6 and 16 is described together with the relationships to IQ, existing measures of attention, and scholastic attainment. This large normative sample also allows us to test the fit of the adult model of functionally separable attention systems to the observed patterns of variance in children's performance. A Structural Equation Modelling approach supports this view. A three-factor model of sustained and selective attention and higher-level "executive" control formed a good fit to the data, even in the youngest children. A single factor model was rejected. There are behavioural and anatomical grounds to believe that Attention Deficit Disorder (ADD) is particularly associated with poor self-sustained attention and behavioural control. The TEA-Ch performance of 24 boys diagnosed with ADD presented here is consistent with this view. When performance levels on WISC-III subtests were taken into account, specific deficits in sustained attention were apparent while selective attention performance was within the normal range.

Activities of Daily Living↗

PubMed2000

Caricaturing facial expressions.

The physical differences between facial expressions (e.g. fear) and a reference norm (e.g. a neutral expression) were altered to produce photographic-quality caricatures. In Experiment 1, participants rated caricatures of fear, happiness and sadness for their intensity of these three emotions; a second group of participants rated how 'face-like' the caricatures appeared. With increasing levels of exaggeration the caricatures were rated as more emotionally intense, but less 'face-like'. Experiment 2 demonstrated a similar relationship between emotional intensity and level of caricature for six different facial expressions. Experiments 3 and 4 compared intensity ratings of facial expression caricatures prepared relative to a selection of reference norms - a neutral expression, an average expression, or a different facial expression (e.g. anger caricatured relative to fear). Each norm produced a linear relationship between caricature and rated intensity of emotion; this finding is inconsistent with two-dimensional models of the perceptual representation of facial expression. An exemplar-based multidimensional model is proposed as an alternative account.

Adult↗

PubMed1996

The structure of normal human attention: The Test of Everyday Attention.

A range of tests of everyday attention is described, based on ecologically plausible activities such as searching maps, looking through telephone directories, and listening to lottery number broadcasts. An age-, sex- and IQ-stratified sample of 154 normal participants was given these tests, along with a number of existing tests of attention. The factor structure revealed by this data set matched well contemporary evidence for a set of functionally independent attentional circuits in the brain, and included factors for sustained attention, selective attention, attentional switching and auditory-verbal working memory. The Test of Everyday Attention (TEA), which was developed and standardized on the basis of these subtests, has three parallel forms, high test-retest reliability, and correlates significantly with existing measures of attention. Furthermore, selected subtests successfully discriminate among a number of brain-impaired groups, including closed head injury versus age-matched controls, minimal versus mild Alzheimer's disease, and progressive supranuclear palsy patients versus age-matched controls.

Activities of Daily Living↗

PubMed1996

Objects and attributes in divided attention: surface and boundary systems.

A series of experiments investigated concurrent discriminations of surface and nonsurface attributes, including color, brightness, texture, length, location, and motion. In all cases but one, results matched those previously reported: Interference occurred when two discriminations concerned different objects, but not when they concerned the same one. In the two-object case, interference was the same whether discriminations were similar (e.g., two surface discriminations) or different (e.g., one surface, one boundary). Such results support a model of visual attention in which separate visual subsystems are coordinated, converging to work on surface and boundary properties of the same selected object. A partial exception is color: For reasons that are unclear, color escapes two-object interference except from other, concurrent surface discriminations.

Adult↗

PubMed1995

Sustained attention training for unilateral neglect: theoretical and rehabilitation implications.

Many studies have shown a co-variation of unilateral neglect with nonlateralised attentional functions. Recently, Posner has argued that there are two separate neural systems that influence the posterior attentional system which is presumed to be impaired in unilateral neglect, namely, the posterior system itself (located partly in the inferior parietal lobules) as well as a secondary modulatory sustained attention or vigilance system. This latter system is linked to the nor-epinephrine system, which is known to be more strongly represented in the right compared to the left hemisphere of the brain. If this hypothesis is true, then unilateral neglect should be improved by increasing activation of the sustained attention system. Eight patients suffering from chronic left unilateral neglect were trained to sustain their attention by a self-alerting procedure partially derived from Meichenbaum's self-instructional methods. Using a multiple-baseline-by-function design, as well as multiple-baseline-by-subject designs, statistically significant improvements in unilateral neglect as well in sustained attention were found following onset of sustained attention training, without corresponding improvements in control measures. Theoretical implications for the attentional underpinnings of unilateral neglect are discussed, as well as the rehabilitation implications of this training procedure.

Aged↗

PubMed1995

Stimulus-independent thought depends on central executive resources.

Stimulus-independent thoughts (SITs) are streams of thoughts and images unrelated to immediate sensory input. Four experiments examined the contribution of aspects of working memory to production of SITs. In Experiments 1 and 2, interventions that were targeted on, respectively, phonological and visuospatial components of working memory both interfered with production of SITs, but there was evidence that these tasks also made demands on central executive resources. Experiments 3 and 4 specifically examined the hypothesis that production of SITs and control of nonproceduralized tasks both depend on central executive resources, and so should show mutual interference. In Experiment 3, prior practice on pursuit rotor and memory tasks reduced the interference with SITs from concurrent task performance. In Experiment 4, randomness within a task involving random-number generation was less when SITs were being produced concurrently than it was when they were not. The results suggest that production of SITs depends on central executive resources.

Adult↗

PubMed1993

Recollecting naturally-occurring intentions: a study of cognitive and affective factors.

This paper is concerned with the recall of naturally-occurring intentions during the interval between their formulation and their enactment, hours, days, or months later. When these intentions were spontaneously recalled, subjects recorded the prevailing cognitive and affective circumstances, and current events and actions. This task was undertaken for a period of five consecutive days. A subsequent task elicited similar information from the same subjects, on randomly sampled occasions that did not coincide with the recall of an intention, during a comparable time period. The results indicate that on occasions on which subjects report these spontaneous recollections, they often judge themselves to be concentrating less on a concurrent activity that requires less attention, compared to occasions on which behaviour is randomly sampled. The results suggest also that this prototypical 'recollective state' may vary with the type of intention that is recalled. The advantages and disadvantages of the methodology adopted in this study for research on prospective memory processes are considered.

Adult↗

PubMed1993

The Spot-the-Word test: a robust estimate of verbal intelligence based on lexical decision.

The development of a test aimed at estimating premorbid intelligence is described. The test, Spot-the-Word, involves presenting the subject with pairs of items comprising one word and one non-word, and requiring the subject to identify the word. Data show that performance correlates highly with verbal intelligence as estimated by Mill Hill Vocabulary score and by performance on the National Adult Reading Test (NART). Performance does not decline with age, in contrast to an associated test of verbal recognition memory. A second study attempted to test the effect of intellectual deterioration due to age on Spot-the-Word performance. Elderly subjects who had high vocabulary scores scored well on the Spot-the-Word regardless of whether fluid intelligence as measured by the AH4 test was well preserved, or was low, implying intellectual deterioration. A final study collected normative data on a sample of 224 subjects stratified by age and socio-economic status, with each subject performing two parallel forms of the test, A and B, together with the NART. Correlation between the two forms was .884, while correlation with NART was .831 for Form A and .859 for Form B, suggesting adequate reliability and validity. It is concluded that the test provides a potentially useful additional method of estimating premorbid intelligence.

Adolescent↗

PubMed1992

Preliminary observations concerning treatment of visual discomfort and associated perceptual distortion.

A system for therapeutic precision tinting is described. Some individuals who are subject to perceptual distortion of text no longer perceive the distortion when the text has a particular colour. A simple colorimeter enables an observer to illuminate text with light of a particular chromaticity, varying first CIE 1976 hue angle (huv), then saturation (suv), and then luminance, to obtain a setting that maximizes visual comfort and reduces any perceptual distortion. The colorimeter setting is then matched by a combination of tinted trial lenses. The combination uses only two dyes at a time from a selection of seven, unless a dark lens is required, when a third neutral (grey) dye is added. The subject observes both text and a normal scene when wearing tinted trial lenses. A variety of trial lenses are compared including those that match the colorimeter setting and others with similar hue angle. Spectacle lenses are then tinted so as to have a spectral transmission identical to that of the chosen combination of trial lenses. Certain patients with reading disorders, eye-strain, headaches or photosensitivity epilepsy report benefit when wearing spectacles tinted according to the above techniques. The physiological basis for the therapeutic effects is uncertain, but may involve a selective impairment of luminance or colour-difference channels.

Adolescent↗

PubMed1992

Autobiographical fluency: a method for the study of personal memory.

Fifty-five subjects recalled autobiographical episodes or personal facts such as names of friends and teachers, from different lifetime periods. In each case, subjects were given 90 sec in which to retrieve as many items as possible. Also tested was subjects' fluency in generating items from semantic categories (animals, vegetables, British prime ministers, and U.S. presidents). Results of cluster analysis on the fluency tasks showed a dissociation between subjects' ability to retrieve personal episodes, personal semantic information, and nonpersonal semantic information. The dissociations observed in the fluency tasks are interpreted in terms of the different retrieval strategies required for the different types of information sought.

Adult↗

PubMed1992

Colorimeter for the intuitive manipulation of hue and saturation and its role in the study of perceptual distortion.

A simple optical method for mixing coloured light is described. The observer has intuitive and approximately independent control over hue and saturation at constant brightness. The method facilitates colour matching by unpracticed observers. It allows children with reading difficulties to select a colour that reduces perceptual distortion of text. The chromaticity coordinates of this colour vary from one observer to another but can be very specific. Complementary colours can exacerbate the distortions and induce pain. For the majority of children reporting beneficial perceptual effects, the u' coordinate is less than 0.25.

Adolescent↗

PubMed1989

The perception of rhythm and word boundaries in noise-masked speech.

The present experiment tested the suggestion that human listeners may exploit durational information in speech to parse continuous utterances into words. Listeners were presented with six-syllable unpredictable utterances under noise-masking, and were required to judge between alternative word strings as to which best matched the rhythm of the masked utterances. For each utterance there were four alternative strings: (a) an exact rhythmic and word boundary match, (b) a rhythmic mismatch, and (c) two utterances with the same rhythm as the masked utterance, but different word boundary locations. Listeners were clearly able to perceive the rhythm of the masked utterances: The rhythmic mismatch was chosen significantly less often than any other alternative. Within the three rhythmically matched alternatives, the exact match was chosen significantly more often than either word boundary mismatch. Thus, listeners both perceived speech rhythm and used durational cues effectively to locate the position of word boundaries.

Cues↗

PubMed1988

Relation between velocity and curvature in movement: equivalence and divergence between a power law and a minimum-jerk model.

Unconstrained hand movements typically display a decrease in hand speed around highly curved sections of a trajectory. It has been suggested that this relation between tangential velocity and radius of curvature conforms to a one-third power law. We demonstrate that a one-third power law can be explained by models taking account of trajectory costs such as a minimum-jerk model. Data were analyzed from 6 subjects performing elliptical drawing movements of varying eccentricities. Conformity to the one-third power law in the average was obtained but is shown to be artifactual. It is demonstrated that asymmetric velocity profiles may result in consistent departures from a one-third power law but that such differences may be masked by inappropriate analysis procedures. We introduce a modification to the original minimum-jerk model by replacing the assumption of a Newtonian point-mass with a visco-elastic body. Simulations with the modified model identify a basis for asymmetry of velocity profiles and thereby predict departures from a one-third law commensurate with the empirical findings.

Adult↗

PubMed1986

Modifications in deaf children's vowel production: perceptual evidence.

This study examined the perceived changes in vowel articulation by profoundly deaf children as a function of the method of teaching: with visual feedback provided by the Computer Vowel Trainer (CVT) vs conventional methods. The assessment carried out by experienced listeners consisted in marking the sounds heard on the vowel quadrilateral. It was found that changes in perception were feedback and age dependent: younger children taught with the CVT were perceived as displaying more mobility in articulation and they approximated more closely the target vowels than their control counterparts or older children. Progress was evident in particular for back and central vowels. Analysis of perceived discrepancies between target and judged vowels, too, suggested that visual feedback was beneficial: perception of experimental children's utterances showed a marked reduction in substitutions with central vowels, a characteristic pattern of deaf speech. Comparison of these findings with the results yielded by the judgement of the same items by naive listeners indicated broad agreement between the two categories of assessors. Results were discussed in terms of the perceptual and articulatory intervening variables with reference to the specific advantages and constraints imposed by evaluating vowel quality on the vowel plane.

Articulation Disorders↗

PubMed1984

A neurological basis for visual discomfort.

Certain patterns of stripes are judged to be unpleasant to look at. They induce illusions of colour, shape and motion that are sometimes perceived predominantly to one side of fixation. People who suffer frequent headaches tend to report more illusions, and if the pain consistently occurs on the same side of the head the illusions tend to be lateralized. The parameters of the patterns that induce illusions (including their shape, spatial frequency, duty cycle, contrast and cortical representation) closely resemble those that elicit epileptiform electroencephalographic abnormalities in patients with photosensitive epilepsy. The viewing conditions under which such abnormalities are likely to appear are also those under which more illusions are seen.

Adolescent↗

PubMed1984

Comparison of auditory filter shapes derived with three different maskers.

Auditory filter shapes were derived for three different masker types, by measuring threshold for a 1-kHz sinusoidal signal masked by: (a) a noise with a spectral notch of variable width; (b) two tones with variable frequency separation; and (c) a noise with a sinusoidally rippled spectrum with variable ripple density. In each case the masker spectrum was symmetric about the signal frequency, the signal level was fixed, and the masker level was varied to determine threshold using an adaptive, two-alternative, forced-choice procedure. Both simultaneous and forward masking were used. The auditory filter shapes derived from the data were broader in simultaneous masking than in forward masking for all three masker types. In simultaneous masking the derived filters were similar for the three masker types, although there was a tendency for the filters derived from the rippled-noise data to be broader than those for the other maskers. In forward masking the auditory filters derived from the data for three masker types differed considerably in bandwidth and the slope of the filter skirts, and in that a portion of the rippled-noise filter was negative valued. The results are consistent with the idea that suppression has the effect of enhancing frequency selectivity, and that this effect is revealed in forward but not in simultaneous masking. However, the degree and nature of the enhancement differs for different masker types.

Auditory Perception↗