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Biomedical subjects

I Norley

Publications and source records attributed to I Norley.

10 recordsLinked to original sources
PubMed1986

Dose requirements of propofol by infusion during nitrous oxide anaesthesia in man. I: Patients premedicated with morphine sulphate.

The study was performed to determine the ED50 and ED95 of a continuous infusion of the emulsion formulation of propofol during 67% nitrous oxide anaesthesia in 57 patients premedicated with morphine sulphate 0.15 mg kg-1. Anaesthesia was induced with propofol 2 mg kg-1, and maintained before incision with a fixed-rate infusion of propofol to supplement nitrous oxide. The response to the first surgical incision, made at least 30 min after induction of anaesthesia, was observed. The ED50 was 53.5 micrograms kg-1 min-1 and the ED95 was 112.2 micrograms kg-1 min-1. At the time of the first surgical incision, the venous whole blood concentrations of propofol at the ED50 and ED95 infusion rates (EC50 and EC95) were 1.66 micrograms ml-1 and 3.39 micrograms ml-1, respectively. The satisfactory maintenance of anaesthesia provided by nitrous oxide supplemented with propofol was associated with haemodynamic stability and rapid, uncomplicated recovery.

Adult↗
PubMed1985

Propofol ('Diprivan') by intravenous infusion with nitrous oxide: dose requirements and haemodynamic effects.

The new formulation of propofol appears to be approximately equipotent to the previous formulation when used as an infusion to supplement nitrous oxide anaesthesia in patients premedicated with morphine. Preliminary haemodynamic studies indicate that the emulsion formulation causes more arterial hypotension than the original Cremophor formulation, though larger numbers are required to confirm this finding.

Adjuvants, Anesthesia↗
PubMed1974

Differential white cell counts by frequency distribution analysis of cell volumes.

Absolute neutrophil and lymphocyte counts on peripheral blood can be made by analysis of the output from a Coulter particle counter, utilizing the difference in the relative cell volume between these two types of cell. A comparison has been made between the results obtained by volume analysis and those obtained by standard microscopical techniques in 10 normal people and 45 patients. The absolute neutrophil count obtained by volume analysis agreed well with values obtained by microscopy; the lymphocyte count did not give such good agreement, since the smaller number of cells counted gave rise to larger sampling errors. The method of volume analysis is suitable for the assessment of absolute neutrophil counts for clinical use.

Blood Cell Count↗