Biomedical subjects
Publications and source records attributed to I O Svider.
Relapses of subacute thyroiditis, hypothyrosis or autoimmune thyroiditis more often develop in the patients with manifest immune shifts after therapy than in those with normal or moderately shifted immune status; this factor appears to be useful for the prediction of the disease outcome and for planning the treatment strategy.
The authors suggest that the prognosis of subacute thyroiditis may be based after treatment on the immunity state. It was revealed that T- and B-lymphocyte as well as nonspecific defence disorders in treated patients with subacute thyroiditis promote more frequent recurrences or hypothyrosis and autoimmune thyroiditis in comparison with patients whose immunity was slightly involved or not involved at all.
Use of glucocorticoid agents in 110 patients with subacute thyroiditis furthered normalization of the cellular, humoral immunity and unspecific defense factors. Clinical signs of the disease disappeared quicker than reduction of the severity of immune and autoimmune disorders evidencing protraction of the disease and necessity of prophylactic treatment and use of additional immunoregulating agents.
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