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Biomedical subjects

I Oda

Publications and source records attributed to I Oda.

34 records · Page 2Linked to original sources
PubMed1999

Endoscopic and histological reversibility of gastric adenoma after eradication of Helicobacter pylori.

Although epidemiological studies strongly suggest an association between Helicobacter pylori infection and gastric carcinogenesis via a multistage process, a causal link between them has not been demonstrated. We evaluated the endoscopic and histological changes of gastric adenoma, which is considered a premalignant condition, after eradication of H. pylori. Thirty-five H. pylori-infected patients with gastric adenoma were treated with triple therapy (lansoprazole 30mg/day, clarithromycin 400mg/day, and amoxicillin 1500 mg/day) for 1 week. Of these 35 patients, 30 (86%) exhibited no H. pylori by culture or histology after the therapy. Of the 30 gastric adenomas, 7 decreased in size endoscopically; three gastric adenomas especially showed apparent remission, although histological cure in these three patients was not apparent. Our results suggest that removal of H. pylori infection may only mask a gastric adenoma endoscopically owing to the change around the gastric mucosa.

2-Pyridinylmethylsulfinylbenzimidazoles↗
PubMed1997

Effects of chondroitinase ABC and chymopapain on spinal motion segment biomechanics. An in vivo biomechanical, radiologic, and histologic canine study.

STUDY DESIGN: The biomechanical effects of chondroitinase ABC and chymopapain related to spinal segmental instability were investigated using a canine model, as well by as radiologic and histologic analyses. OBJECTIVES: To evaluate the biomechanical, radiologic, and histologic affects on the lumber intervertebral disc of chondroitinase ABC compared with chymopapain. SUMMARY OF BACKGROUND DATA: No study on the biomechanical effects of chondroitinase ABC has been reported. METHODS: Forty-eight lumbar intervertebral discs in eight beagles were randomly assigned to three groups and received one of three materials: chondroitinase ABC, chymopapain, or buffered saline, using a lateral percutaneous procedure. One week after injection, the animals were killed and the lumbar spinal motion segments were removed. Spinal segmental instability after chemonucleolysis was evaluated in spinal motion segments without posterior elements. Radiologic and histologic changes were also investigated. RESULTS: Spinal segmental instability and disc space narrowing were more greater in the chymopapain group than in the chondroitinase ABC group. Destruction of nucleus and anulus proteoglycans, indicated by loss of safranin-O staining, was less intense in chondroitinase ABC-injected discs. CONCLUSIONS: Chondroitinase ABC results in less spinal segmental instability, disc space narrowing, and destruction of proteoglycans in intervertebral disc matrix than chymopapain.

Animals↗
PubMed1996

Biomechanical role of the posterior elements, costovertebral joints, and rib cage in the stability of the thoracic spine.

STUDY DESIGN: This is a biomechanical study of the thoracic spine. Various ligaments and joints were resected sequentially and nondestructive cyclic loading tests were performed. Effects of each resection were analyzed biomechanically. OBJECTIVES: To investigate the role of the posterior elements, costovertebral joints, and rib cage in the stability of the thoracic spine. SUMMARY OF BACKGROUND DATA: There have been no experimental studies concerning the mechanical interaction between the thoracic spine and rib cage. METHODS: Eight canine rib cage-thoracic spine complexes, consisting of the sixth to eighth ribs, sternum, and T5-T9 vertebrae, were used. Six pure moments along three axes were applied to the specimens, and angular deformation of T6-T7 was recorded. After testing the intact specimen, resection of the stabilizers was conducted incrementally in the following manner: 1) removal of the posterior elements at T6-T7, 2) resection of the bilateral seventh costovertebral joints, and finally, 3) destruction of the rib cage. The same loading tests were repeated at each stage. The ranges of motion and neutral zones were calculated by digitization. RESULTS: A large increase in the range of motion in flexion-extension was observed after resection of the posterior elements and in lateral bending and axial rotation after resection of the costovertebral joints. A significant increase in the neutral zone in lateral bending and axial rotation was observed after bilateral resection of the costovertebral joints and destruction of the rib cage. CONCLUSIONS: The costovertebral joints and rib cage play an important role in providing stability to the thoracic spine. The state of the costovertebral joints and rib cage should be assessed to evaluate the stability of the thoracic spine.

Animals↗
PubMed1989

[Radiation therapy of choroidal metastases].

A retrospective study was performed on 30 cases with choroidal metastases referred to the Cancer Institute Hospital between July 1975 and June 1986. Of these 30 cases, 32 eyes of 26 patients were treated with irradiation of 4.3 MV X-rays or 12 MeV electron beam therapy in the range of 20-60 Gy to restore vision and prevent blindness. The tumor response to radiation therapy confirmed by ophthalmoscopic examination was described as complete, partial or no response. Of the 32 eyes, 31% had complete response, and 47% showed partial response. The overall response rate was 78%. A visual response as defined by marked or partial improvement of visual acuity and/or subjective symptoms was obtained in 16 out of 26 patients (62%). All of these patients were free of recurrence of symptoms in their quality of life. This proved radiotherapy to be a useful modality of treatment for choroidal metastases. No obvious radiation injuries were encountered in this series.

Adult↗
PubMedDate not supplied

Early gastric cancer: endoscopic mucosal resection.

In Japan, endoscopic mucosal resection (EMR) is now accepted as a treatment option for cases of early gastric cancer (EGC) with minimum probability of associated lymph node metastasis. In National Cancer Center Hospital (NCCH), EMR is currently applied to patients with early cancers up to 30 mm diameter that were of intestinal type, and were superficially elevated and/or depressed (Type I, IIa and IIc) but without ulceration or definite signs of submucosal invasion. Four hundred seventy nine lesions of EGC in 449 patients were treated by EMR from 1987 through 1998. Submucosal invasion was found on subsequent pathologic examination in 74 lesions, and surgery was recommended. Sixty nine percent of intramucosal cancer was resected with a clear margin, which was therefore judged to be a "complete resection". Local recurrence in the stomach occurred in 2% (5 lesions) with complete resection and in 17% (18 lesions) without complete resection treated conservatively or endoscopically, and all were subsequently treated with curative intent. There were no gastric cancer-related deaths for a median follow-up period of 38 months (3-120 months). Bleeding and perforation were two major complications in EMR, but there were no treatment-related deaths. We believe that EMR allows us to perform less-invasive treatment without sacrificing the possibility of cure. We hope to promote its use around the world.

Gastric Mucosa↗