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Biomedical subjects

I Oi

Publications and source records attributed to I Oi.

At least 19 recordsLinked to original sources

ERCP imaging.

Localization and spread of pancreatic diseases has been a reality since the availability of endoscopic pancreatography in the late 1960s, particularly after development of a fiberscope for this purpose. Endoscopic pancreatography allowed the clinician to discern the position and site of cancers, cysts, and localized inflammations. Ductal anomalies, such as annular pancreas, nonfusion, and anomalous junction of pancreatobiliary connection, were clearly recognized also. The pancreatography opacified the real lumen instead of the virtual images of ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI), so that precise studies comparing histopathologic details could be performed. The pancreatic ductal information visualized by using the fiberscope changed our understanding of chronic inflammation of the pancreas. Chronic diffuse pancreatitis, upstream pancreatitis, ductitis, and duct-narrowing pancreatitis were specified from their pathogenetic differences. Although the noninvasive methods such as US and CT will be the first choice for the diagnosis of pancreatic diseases, pancreatography will still be important for the morphologic studies of the pancreas in various disease conditions.

Cholangiopancreatography, Endoscopic Retrograde

[Portal hemodynamic changes from TIPS--evaluation with pulse Doppler method].

Transjugular intrahepatic portosystemic shunt (TIPS) was applied in three patients with Child C liver cirrhosis. Portal venous pressure was reduced by an average of 10.7 mmHg, and results such as the disappearance of esophageal varices and reduction in ascites were obtained. The portal hemodynamics of these three patients was observed before and after TIPS using the pulse Doppler method. When portal hemodynamics in the main portal vein was examined before TIPS, it was found that the mean blood flow velocity had decreased, the blood flow volume was reduced and the cross-sectional area of the vein had increased. The congestion index was high and there was definite congestion of the portal venous system. After TIPS, the blood flow velocity and volume increased, the cross-sectional area of the vein was reduced and the congestion index was lower. Congestion of the portal venous system was improved in these three patients and the clinical efficacy of TIPS was proven by these results. If the stent can be detected sonographically, stent patency is easily confirmed with the pulse Doppler method which is usefull examination technique for follow-up of patients undergoing TIPS.

Aged

[Diagnosis of cholelithiasis--endoscopic pancreatocholangiography].

Endoscopic cholangiography is fundamentally evaluated as X-ray anatomy of the biliary system as well as the principal technique for endoscopic treatments that is endoscopic papillotomy and endoscopic drainage, while gallstone is routinely diagnosed by ultrasonography in medical practice. By endoscopic cholangiography, stones in the cystic duct and the common bile duct are confirmedly diagnosed in the same quality as gallbladder stones, and the anatomical information of the cystic duct, the gallbladder, and the duodenal papilla are clearly demonstrated, which are required in many therapeutic procedures for gallstones diseases including laparoscopic cholecystectomy.

Cholangiopancreatography, Endoscopic Retrograde

Technical guidance of endoscopic pancreatocholangiography.

Endoscopic pancreatocholangiography, frequently abbreviated as ERCP, is an X-ray examination of the pancreatic and biliary ducts cannulating the duodenal papilla using the fiberscope. This procedure is the only clinical examination of the pancreatic duct, and is an indispensable technique for endoscopic treatments and further investigations: endoscopic papillotomy, drainage, lithotomy, endoprothesis, pancreatoscopy, and collection and cytology of pure juice. For this examination, a skill in endoscopy is required, and the understanding of the papilla orifice, which consists of prolapsed ampullar folds in the living body, is essential. The catheter should be inserted straight toward the individual duct: the pancreatic and the biliary duct. As ultrasonography and computed tomography are advanced, the clinical roll of ERCP should be reevaluated. However, the pancreatography expresses exactly the ductal pathology, which is reflected by the background pathology of the pancreas: chronic pancreatitis, nonfusion, pancreatobiliary maljunction, small cancerous, mucous-producing tumors, and cystic lesions.

Cholangiography

[Non-fusion of the ventral and dorsal pancreatic ducts].

Non-fusion of the ventral and dorsal pancreatic ducts is an anomaly of the ductal system of the pancreas; no connection between the ventral and the dorsal pancreatic ducts. The pancreas, however, keeps normal shape examined by US, CT, and laparotomy. The dorsal pancreatography through the accessory papilla is essential in diagnosis of non-fusion, because the short pancreatic duct through the main papilla is sometimes observed in chronic pancreatitis, anomalous defect of the distal pancreas, pancreatic cancer, and cyst. The 30 cases of the non-fusion were experienced in our institute which were all confirmed by dorsal pancreatography; they were nearly half of the confirmed cases in Japan. The incidence is 0.5% in about 6000 endoscopic pancreatographies during 1969-1984. The age distribution is 25-79 year-old, the average 44.7, and 19 cases are male and 11 female. The pancreatitis-like pain is frequently observed in cases with non-fusion. The 13 cases, 43%, in our series complained of pancreatic pain (called P-group), but the other 17 did not (called non-P group). The age distribution, sex, and the incidence of alcohol intake, DM, gallstone diseases, however, are not different between these two groups. The figure of the ventral pancreatic duct was not characteristic in both groups. The obvious chronic pancreatitis (chronic dorsal pancreatitis) is only two even in P-group and none in non-P group. The pancreatitis-like pain may be occurred by the reason why the functionally lesser accessory papilla which is an only out-left of the larger dorsal pancreas in non-fusion could not adapt the over-load for the pancreas, for example by alcohol. The non-fusion of the pancreatic duct system is not a direct cause of pancreatitis but might be a disposition of it.

Adult

[Carcinoembryonic antigen (CEA), serum amylase and pancreozymin-secretin test in relation to stages of pancreatic cancer].

In cases of surgically proved pancreatic carcinoma, preoperative values of serum CEA, serum amylase and pancreozymin-secretin test (PST) were seen if they related to the macroscopic stages of the tumor determined by "General Rules for Surgical and Pathological Studies on Cancer of Pancreas" offered by Japanese Pancreatic Society in April 1982. Serum CEA was determined in 43 cases, serum amylase in 34 cases and PST was done in 28 cases. All of CEA, amylase and PST showed no statistically significant relationship to the stages of the carcinoma. This may suggest that these tests may not be a useful indicator of the stage of tumor.

Amylases

Remote contrast injector in ERCP for protection from X-ray exposure.

To protect the assistants from radiation during ERCP, a remote contrast injector employing a lever mechanism (push lever type) was developed. Using this remote injector, safe, finely controlled and easy injection of the contrast material was achieved without X-ray exposure to the assistants in ERCP.

Cholangiopancreatography, Endoscopic Retrograde

Lipase activity in blood following endoscopic pancreatography: demonstration of its pancreatic origin and existence of ductal or acino-venous pathways in man.

The presence of a lipase activity has been observed in the blood of patients undergoing an endoscopic retrograde cholangio-pancreatography (ERCP). The identity between this serum lipase and pancreatic lipase has been demonstrated by their similarity in in chromatographic, immunological, and catalytic properties. Lipase activity in serum increased when pancreatography was accompanied by a passage of the contrast medium to the kidney demonstrating the presence of ductal or acino-venous pathways in man.

Cholangiography