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Biomedical subjects

I Omura

Publications and source records attributed to I Omura.

At least 19 recordsLinked to original sources
PubMed2004

Changes in the concentrations of tetrahydrobiopterin, the cofactor of tyrosine hydroxylase, in blood under physical stress and in depression.

This paper studies changes in the concentrations of tetrahydrobiopterin (BH4), the cofactor of tyrosine hydroxylase, in blood under physical stress and in depression. BH4 was found to be transiently released from the sympathetic nerves under severe physical stress but continuously released in depression with an increased oxidation rate of BH4 to B.

Adolescent↗
PubMed2000

Transient seizure disappearance due to bilateral striatal necrosis in a patient with intractable epilepsy.

An 8-year-old girl had suffered from intractable epilepsy due to cortical dysplasia. She developed mycoplasma pneumonia with massive pleural effusion. Fever continued for 3 weeks. Four weeks after the onset of this infection, she suddenly developed horizontal nystagmus, ataxia, choreoathetotic movements and confusion. CT disclosed swelling and low density of the heads of the caudate nuclei and putamina bilaterally. MRI revealed areas of symmetrical high intensity in the striatum on T2-weighted imaging. These lesions were thought to comprise bilateral striatal necrosis (BSN) mediated by the mycoplasma infection or Wernicke encephalopathy. Six months later, she had completely recovered clinically. During the 6 months after BSN, she did not have any epileptic seizures. Her epileptic seizures reappeared thereafter at a lower frequency. The striatum may be involved in the propagation pathway for epileptic seizure activity in this patient.

Cerebral Cortex↗
PubMed2000

[Two cases of auditory disturbance caused by carbamazepine].

Two cases of auditory disturbance caused by carbamazepine are reported. Patient 1, a 9-year-old boy with benign Rolandic epilepsy, developed impairment of pitch perception one day after administration of carbamazepine. Patient 2, a 33-year-old female with glossopharyngeal neuralgia, developed impairment of pitch perception several hours after administration of carbamazepine, complaining that the perceived sounds became lower than previously by a semitone. Her pitch perception recovered soon after the cessation of carbamazepine. The carbamazepine-induced disturbance in pitch perception may be more frequent than we guess.

Adult↗
PubMed1989

[Studies on the pre-treatment of dental alloy for adhesive restorations. 4. Adhesive durability of adhesive resin to various dental alloys treated with composite plating].

In this study, the durability of adhesion between an adhesive resin (Panavia EX) and dental alloys (gold or Ni-Cr) were examined in regard to thermal cycling, immersion, either in water (70 degrees C or 100 degrees C) or in sodium chloride solutions (pH was 3, 7 and 9). An favourable adhesive strength, such as 450-500 kgf/cm2, was obtained even after 24 hours immersion in 37 degrees C water, when the surface pre-treatment of the alloy was done with either Sn- or composite (TMSAC/Sn or PVC/Sn)-plating. However, during the durability test, the adhesive strength has decreased to such on extent, that about 60% of early strength with Sn-plating and 80% with TMSAC/Sn composite plating. But, with PVC/Sn composite-plating, more than 90% of the early strength was maintained. In regard to the pH of the corrosive solution, no apparent difference was observed regarding the above mentioned adhesive characteristics.

Adhesiveness↗
PubMed1989

[Pre-treatment of dental alloy for adhesive restorations. Part 3. Alkyl ammonium/Sn composite plating to various dental alloys].

The effect of alkyl ammonium salt/Sn composite plating on the adhesive characteristics of dental alloys was examined. The surface of dental alloys, on which such a composite plating was made, was analyzed by ESCA. The effect of the length of alkyl chain and its terminal atomic groups on the tensile adhesive strength to an adhesive resin was also examined. ESCA analysis revealed that both C and N atoms from the alkyl ammonium salts were certified on the surface of the dental alloys. Stable tensile adhesive strength, as high as 500 kg/cm2, was obtained when the number of C atoms of alkyl chain was 10 to 16. The alkyl ammonium salts containing such groups as hydroxyl, amino and vinyl at the terminal of the alkyl chain, were effective for increasing the tensile adhesive strength.

Adhesiveness↗
PubMed1987

The complete cancellation of abnormal Q waves due to an old anteroseptal infarction following subsequent acute posterior myocardial infarction.

A rare case of multiple infarction is described. An abnormal Q wave due to an old anteroseptal infarction was completely masked by a new contralateral posterior myocardial infarction. Coronary angiogram revealed multiple stenoses of segments 1 (100%), 7 (99%), 12 (90%) and 13 (99%). Left ventriculography also showed akinesis of segments 2, 3 4 and 6, and reduced wall motion in segments 1, 5 and 7. These findings, together with electrocardiographic changes from before the present attack reinforce the above interpretation.

Aged↗
PubMed1986

Effects of oral diltiazem on ventricular premature contractions.

The effects of oral diltiazem (90-180 mg/day for four weeks) on ventricular premature contractions (VPCs) were studied in 16 patients with frequent VPCs using 24-hour ambulatory ECG recordings. VPC frequency was evaluated as a function of underlying heart rate. Plots of VPC frequency vs. heart rate were made at 1-beat/min intervals for all heart rates recorded for at least five minutes during 24 hours. Patterns of correlation between VPC frequency and heart rate observed before diltiazem therapy included: 1) a relatively linear increase in VPCs with heart rate (positive correlation) in ten patients, 2) a linear decrease (negative correlation) in one patient, and 3) an increase at low heart rates and a decrease at high heart rates (bidirectional correlation) in five patients. Diltiazem significantly reduced the mean VPC frequency per 24 hours for patients with a positive correlation, but induced no significant change for patients with a negative or a bidirectional correlation. At the 65% level of VPC reduction, diltiazem was effective in eight of ten patients with a positive correlation but was not effective in the six patients with other correlations (p less than 0.01). These results suggest that an evaluation of VPC frequency as a function of heart rate predicts the response of VPCs to diltiazem.

Administration, Oral↗
PubMed1983

Physical constitution and smoking habits of patients with idiopathic spontaneous pneumothorax.

This is a report on a statistical study comparing the Kaup index and the level of tobacco consumption of patients with idiopathic spontaneous pneumothorax and those of healthy subjects. A statistically significant difference was found between the average Kaup index of the patients with idiopathic spontaneous pneumothorax and that of normal healthy individuals in Japan as published by the Ministry of Health and Welfare. A statistically significant difference was also found in the physical features between 2,433 males with idiopathic pneumothorax and 1,906 healthy males when compared by means of the Kaup index. Again, a statistically significant difference was noted in the level of tobacco consumption between the males with idiopathic pneumothorax and normal males when compared by means of the Brinkmann index. The Kaup index of idiopathic pneumothorax patients was lower than that of healthy subjects, while the level of tobacco consumption of the former was higher. Idiopathic spontaneous pneumothorax is related to thin and tall individuals and the level of tobacco consumption among such patients is higher than among healthy subjects.

Adolescent↗