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Biomedical subjects

I P Coleman

Publications and source records attributed to I P Coleman.

6 recordsLinked to original sources
PubMed1994

A computer simulation for learning about the physiological response to exercise.

An interactive computer program written for IBM-compatible microcomputers, which simulates the physiological response to graded exercise in healthy individuals, is described. The program presents high-resolution graphic data (heart rate, pulmonary ventilation, oxygen consumption, and blood lactate concentration) in a form comparable to that of a chart recorder display. Data are derived from an empirical model that allows users to select certain parameters of the subject they wish to investigate, including sex, age, height, weight, and level of training. Measurements may be taken directly from the monitor screen by use of the cross-hair cursor facility provided. The program has been positively evaluated in use by undergraduate students and shown to be an effective teaching aid. The potential use of the software in light of these findings is discussed.

Adolescent↗
PubMed1979

The transport of the lead cation across the intestinal membrane.

1. The transport of the lead cation has been investigated using the everted sac preparation of Wilson & Wiseman (1954).2. Only a small percentage of lead was transported into the serosal compartment but there was a rapid and massive uptake onto the tissue. There was no significant difference in the amount of lead cations transported across different regions of the small intestine.3. Both the rate of transport into the serosal compartment and the tissue uptake increased linearly with increasing concentration of the lead cation, from 10(-7)M to 5 x 10(-5)M. Little evidence for saturation of serosal transport or tissue uptake was found.4. Lead transport into the serosal compartment appeared to be related to water movement, but was little affected by changes in glucose concentration and temperature.5. It is concluded that lead is transported into the serosal space by a process of passive diffusion linked to water transport.6. The interaction between lead ions and the intestinal tissue was extremely tenacious and displayed characteristics of covalent bonding.7. It is suggested that the lead cation interacts with tissue phosphate ions thus removing lead ions from the transport pool. Chelation of lead to form a neutral species reduces this interaction and also promotes transport.

Animals↗