Biomedical subjects

I P Tonk

Publications and source records attributed to I P Tonk.

6 recordsLinked to original sources

PubMed1986

Mercuric chloride-induced physiological dysfunction in Notopterus notopterus.

The freshwater fish Notopterus notopterus were exposed to various sublethal concentrations (0.088, 0.044, 0.029, 0.022, and 0.017) of mercuric chloride (HgCl2) mg/liter for 15, 30, 45, and 60 days, and their effects on glucose, lactate, cholesterol, plasma glutamic oxalacetic transaminase (PGOT) and plasma glutamic pyruvic transaminase (PGPT) of the blood were observed. Lactate increased significantly (P less than 0.05; P less than 0.01; P less than 0.001) and glucose. PGOT, and PGPT increased significantly (P less than 0.05; P less than 0.01). However, cholesterol decreased significantly (P less than 0.05; P less than 0.01; P less than 0.001) in the blood of N. notopterus.

Alanine Transaminase↗

PubMed1985

In vivo accumulation and effects of mercuric chloride on tissue phosphatases of Notopterus notopterus.

Sublethal concentrations of mercuric chloride inhibited the liver, kidney and gill enzymes, acid, alkaline, and glucose-6-phosphatase of the fish Notopterus notopterus, which had been exposed to the heavy metal for 30 days. Higher concentrations produced highly significant (p less than 0.001) inhibition, whereas concentrations that were 1/25th the lethal concentration caused significant (p less than 0.05)/insignificant inhibition. The quantity of mercuric chloride accumulated in tissues correlated with the degree of enzyme inhibition.

Animals↗

PubMed1984

Mercuric chloride stress on serum transaminase activity in Notopterus notopterus.

Mercuric intoxication at sublethal levels (1/5, 1/10, 1/15, 1/20 or 1/25 fractions of 96 h LC50) produced alterations in the activity of serum glutamic oxalacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) of Notopterus notopterus. The difference between control and treated fish was found to be significant at P less than 0.05, P less than 0.01 and P less than 0.001 levels. Maximum (81.75%) significant (P less than 0.001) effect was observed in SGOT: maximum (69.23%) significant (P less than 0.001) effect was observed in SGPT in fish exposed for 60 days.

Alanine Transaminase↗

PubMed1983

Pesticide-induced dysfunction in carbohydrate metabolism in three freshwater fishes.

In the present investigation, the effect of sublethal fractions (1/4th, 1/8th and 1/16th of 96-hr LC50) of thiotox and dichlorvos on blood glucose, lactate, and liver and muscle glycogen levels of Clarias batrachus, Saccobranchus fossilis, and Mystus vittatus, exposed for 30 days, have been studied. It was observed that blood glucose and lactate levels increased from 29.13 to 98.36% and from 10.88 to 36.36%, respectively. The liver and muscle glycogen decreased from 22.99 to 69.30% and from 5.19 to 32.19%, respectively. The reasons for this carbohydrate imbalance have also been suggested.

Animals↗

PubMed1983

In vivo effect of mercuric chloride on tissue ATPases of Notopterus notopterus.

Effect of sublethal concentrations, 0.088, 0.044, 0.029, 0.022 and 0.0176 mg HgCl2 per liter (1/5, 1/10, 1/15, 1/20, and 1/25 fractions of 96-h LC50) on Na+-K+, Mg2+, and total ATPase activities in brain, gills, kidney and liver of Notopterus notopterus have been studied after 30 days exposure. Na+-K+ ATPase were inhibited maximally and significantly in brain and minimally and insignificantly in liver. Mg2+ ATPase was inhibited maximally and significantly (P less than 0.01) in brain and minimally and insignificantly in kidney. The relative inhibition of total, Na+-K+ and Mg2+ ATPases for the tissues studied were brain greater than gill greater than kidney greater than liver. At the concentration (1/25 fraction) the enzyme activity returned to the normal range.

Adenosine Triphosphatases↗

PubMed1982

Effects of a few xenobiots on three phosphatases of Saccobranchus fossilis and the role of ascorbic acid in their toxicity.

The effects of 0.0021, 0.00126 and 0.00063 mg thiotox per liter and 5.18, 3.11 and 1.56 malathion per liter (1/3, 1/5, and 1/10 fractions of 96-h LC50) on acid, alkaline and glucose-6-phosphatases in liver, brain and gills of Saccobranchus fossilis were studied after 30 days exposure with or without ascorbic acid. These enzyme activities were altered by these pesticides, but lesser alterations were observed when ascorbic acid was given.

Acid Phosphatase↗