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Biomedical subjects

I Palatsi

Publications and source records attributed to I Palatsi.

8 recordsLinked to original sources

Cell-mediated immune response during primary Chlamydia pneumoniae infection.

The development of Chlamydia pneumoniae-specific cell-mediated immunity was studied during a primary C. pneumoniae infection. The immune response was detected as positive lymphocyte proliferation and secretion of interferon gamma. C. pneumoniae-induced activation of both CD4(+) and CD8(+) T cells was detected in the early phase of infection, but activation of only CD4(+) T cells was detected in the later stage.

Adolescent↗

Impaired left ventricular diastolic function in athletes after utterly strenuous prolonged exercise.

Digitized M mode echocardiography was used to evaluate the effect of a competitive 24-h run on the left ventricular diastolic function in 12 well-trained marathon runners who completed 146-227 km during the race. Mitral valve opening was delayed, early diastolic filling was decreased and prolonged, and posterior wall thinning was reduced, particularly among those athletes completing close to 200 km or more. Since the alterations were in part the opposite in those running 160 km or less, only the reductions in the peak rate of dimension increase (P less than 0.05) and posterior wall thinning (P less than 0.01) were significant in the group as a whole. The delay in mitral valve opening (r = 0.76), the decrease in the peak rate of dimension increase (r = -0.68), and the prolongation of the early diastolic filling period (r = 0.60) were correlated with the distance completed. The reductions in left ventricular end-diastolic dimension and fractional shortening were not in proportion to the distance run, however (r = 0.23 and 0.46, respectively). Measurements made on six athletes 2-3 days after the race showed reversal of the indices of left ventricular diastolic function. Extremely exhaustive prolonged exercise thus appears to result in a marked reversible impairment in left ventricular relaxation and filling. Since the effect of these abnormalities in cardiac filling during exercise is probably more important due to the shorter diastole, the prevention of hypohydration, which could otherwise further compromise left ventricular filling, becomes crucial.

Adult↗

The oxygen uptake - work-output relationship of runners during graded cycling exercise: sprinters vs. endurance runners.

In order to study oxygen consumption (VO2) for a given work load at the exhaustive level of a graded cycling exercise in well-trained runners, a progressive cycle ergometer exercise test was performed on 9 sprinters and 12 endurance runners, all in good national standing; 12 sedentary men served as control subjects. The relationship between VO2 and work-output appeared to be linear in most of the subjects, but a plateau phenomenon was observed in two sprinters and two endurance runners. An upwards curvilinear increase in VO2 was noticed during the last two minutes of exercise in four endurance runners, but not in any of the sprinters. The four endurance runners with this unexpected increase in VO2 had a significantly higher (p < .01) "peak VO2" (mean = 75.3 ml.kg.-1.min.-1) than the rest of the endurance runners (mean = 55.1), and a significantly higher (p < .001) peak VO2 than the sprinters (mean = 46.0). It is concluded that the plateau phenomenon appears in runners during graded cycle ergometry, though rather seldom. It is less clear if the endurance runners showing the upwards curvilinear increase in VO2 possess a better aerobic performance capacity towards the end of progressive exercise. Nevertheless, the linear relationship between VO2 and work load does not appear to be the only one observed in runners during graded exercise.

Adult↗

Ergospirometry and coronary arteriography in young patients with angina pectoris or atypical chest pain.

A bicycle ergospirometric test was performed on 57 women and 26 men of age 40 or less in combination with coronary arteriography for angina pectoris or chest pain atypical for ischaemia severe enough to affect their working capacity. Nine men and 14 women had angina pectoris with coronary artery narrowings of 50% or more (Group I) and 5 men and 22 women had angina pectoris without obvious coronary artery narrowings (Group II). This means an incidence for coronary changes of 64% for men and 38% for women for angina pectoris. Group III consisted of 12 men and 21 women with a chest pain atypical for ischaemia and without coronary artery narrowings. Minor changes were found on angiographic examination in some patients. Four men and 11 women could not do the ergospirometry adequately. The patients with coronary artery narrowings had a lower maximal oxygen consumption than the others, even though only the mean values for the women showed a statistically significant difference. They also had lower maximal heart rates and their total work and maximum load were lower. The highest proportion of ST segment depressions of 0.5 mm or more was also found in the same patients. The pressure rate product did not show any clear difference with regard to the patient groups or the ST segment changes. As a purely diagnostic tool ergospirometry does not give more information about possible ischaemia in cases of chest pain than a routine upright bicycle test, but for following up patients with angina pectoris and evaluating treatment it gives valuable data about working capacity.

Adult↗

Feasibility of early mobilization after acute myocardial infarction.

The purpose of the study was to determine the proportion of patients with acute myocardial infarction (AMI) for whom an early programme of mobilization, independent of sex and age was possible, and the main reasons for delay of mobilization. Mobilization according to the programme (sitting on day 2 and standing on day 3) succeeded for 49% of the 241 patients alive and conscious after the 1st day, and there were no significant difference with regard to age and sex. The main reasons for delayed mobilization were prolonged chest pain, conduction disturbances and pulmonary oedema. Discharge on day 10 was feasible for 58% of the 241 patients alive and conscious after the 1st day. The mean hospital stay of the patients discharged later than that was 17.3 days. The reasons for the delayed discharge were delayed mobilization, chest pain persisting while in the ward, reinfarction, social, and other reasons. Early programmed mobilization was thus feasible for almost half the patients, and mobilization had been started in over 90% of the patients by the 5th day. Nevertheless, the remarkably high proportion of readmissions (13.3% of all discharged patients) and reinfarctions (6.9%) within the 30 days following discharge may indicate disadvantages in the early mobilization of some patients.

Acute Disease↗

Feasibility of physical training after myocardial infarction and its effect on return to work, morbidity and mortality.

The purpose of this work on patients with myocardial infarction was to find out whether physical rehabilitation based on spontaneous home training can be carried out in practice, and whether such rehabilitation brings about favourable changes in the symptoms, clinical findings and metabolic risk factors. A further objective was to find out whether the physical condition of the patients is improved, and whether the rehabilitation has any effect on the prognosis and return to work. The training group consisted of 180 patients, 143 men and 37 women. The control group comprised 200 patients, 166 men and 34 women. All the patients were of working-age, (under 65 yrs) and all were treated in the Clinic of Internal Medicine, University Central Hospital of Oulu. Mobilization was early: the intramural infarctions were discharged on the 12th day, and the transmural ones on the 16th day. Rehabilitation was started 10 weeks after the onset of infarction. The training subjects came for a chalistenic session in groups of 5-7, once a month. During the session they learnt a 30-minute series of chalistenic movements under the instruction of a physiotherapist, and the supervision of a physician. The chalistenic program was an interval type program, involving all the large muscle groups and including running on the spot. The training became progressively more strenuous every month. The trainers were to perform the program every day at home. During each session in a gymnastic hall, the subjects took a bicycle ergometer test. The controls came for an ergometric test monthly. The patients were examined in an outpatient department every third month. The improvement of their physical condition was followed by determining the submaximal value of aerobic power, measured as the work load at a heart rate of 130 per minute (Physical Working Capacity 130). Furthermore, the subjective maximum-of about one fourth of the trainers and controls was determined in the ergometric test. The program turned out to be suitable. After 6 months, 78% of the training men and 65% of the training women were still participating, and 67% of the training men and 62% of the training women attended the last session after 12 months. The chalistenic home program was carried out enthusiastically. Of the training men who were still participating after 6 months, 55% did their exercises on 6-7 days of the week, the corresponding figure for the training women being 70%; after a year 51% of the men and 73% of the women were still equally active. At the time of the 12-month checkup, 15% of the men and 14% of the women did an insignificant amount of chalistenic exercises (0-2 times a week). Rehabilitation had no effect on the clinical condition of the trainers, for no significant differences were noted in the symptoms of coronary disease and the clinical findings between the training subjects and the controls. One indication of a possible favourable training effect was the decrease of prolonged chest pains in the male training group, during the follow-up period. The blood pressure of the training men and the training women declined, but the difference in comparison with the controls was not significant. At the end of the follow-up year the training men were less fatigued subjectively than the controls, which may be indicative of a favourable psychic effect of rehabilitation. Rehabilitation had no effect on the smoking habits. There were no significant differences in the ECG findings between the trainers and the controls. The relative heart volume of both the training men and the training women increased during the year. In the initial checkup, the mean relative heart volume of the training men was 496 cm3/m2 and that of the training women 487 cm3/m2, while at the end of the year the figures were 506 cm3/m2 for men and 530 cm3/m2 for women. The difference between the trainers and the controls was almost significant in both groups at the end of the year. The clinical findings in the training group showed no signs of an increase of heart failure at the end of the year. Rehabilitation had no effect on serum cholesterol, serum triglycerides or serum urate, or 2-hour glucose tolerance. No association between training and the increase in physical working capacity 130 could be shown. PWC 130 increased significantly in the groups of trainers and controls, but more so in the control group. At the end of the year, the trainers had a 13.3% higher PWC 130 and the controls an 18.3% higher PWC 130 than observed initially. PWC 130 improved by over 20% in 39.1% of the trainers and 44.6% of the controls. The physical working capacity improved more rapidly in the group of trainers than in the control group. Those training men, however, for whom the subjective maximum was determined, seemed to improve their physical working capacity more than the controls, for the subjective maximum of the training men improved significantly (39.3%). The improvement among the control men was not significant (31.7%). The training effect achieved by the training men was probably peripheral, and did not become manifest in the PWC 130 measurements. Rehabilitation had no effect on the return to work. Forty (42.1%) of the training men recovered their working capacity, and 37 (39%) of these returned to their previous employment; the corresponding figures for the control men were 36 (33%) and 35 (32.1%). Seven (25.9%) of the training women and 5 (33.3%) of the control women resumed their previous employment. The prognosis of the training subjects was followed for an average of 31.5 months and that of the controls for an average of 26.5 months. During the follow-up period, 21 trainers (11.7%) and 29 controls (14.5%) suffered a re-infarction. There were 18 (10%) coronary deaths in the training group and 28 (14%) in the control group. During the first year 3.5% of the trainers and 8% of the controls died. During the second year mortality was 3.6% in the training group and 5.5% in the control group. The trainers and controls did not differ significantly as regards recidivous infarctions and coronary deaths. It should be noted, however, that the differences in both recidivous morbidity and coronary mortality were always in the same direction: the trainers had lower values of recidivous morbidity and coronary mortality than the controls. Training may have had an effect on the prognosis.

Employment↗