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I Papadopoulos

Publications and source records attributed to I Papadopoulos.

18 recordsLinked to original sources
PubMed1991

[Inferior vena cava compression syndrome in cystic kidney. Duplex ultrasonic diagnosis].

Four months after renal transplantation for polycystic renal degeneration a 38-year-old man developed breathing-related pain in the left upper lung and a sinus tachycardia (130/min). Lung perfusion scintigraphy demonstrated pulmonary emboli from an acute venous thrombosis of the left lower leg. Polycythaemia and impairment of clot-inhibiting factors were excluded. Ultrasound examination of the abdomen revealed stenosis of the inferior vena cava (IVC) distal to the hepatic veins, dorsal to the liver and ventral of a huge right polycystic kidney which had been left in situ at the time of the renal transplantation. Duplex sonography demonstrated a band-like flow profile in the region of the stenosis. Blood flow was clearly increased (0.62 m/s) and not affected by either heart rate or breathing movements. The findings were confirmed by angiography. The right kidney, weighing 5 kg, was removed at surgery. The IVC stenosis was postoperatively found to be relieved and duplex sonography gave normal findings.

Adult↗
PubMed1991

LHRH analogues do not protect the germinal epithelium during chemotherapy. An experimental animal investigation.

The protective effect of Decapeptyl, a D-Trp6-LHRH analogue, on the germinal epithelium of rats during chemotherapy was examined in an experimental animal study. Four groups were formed consisting of 15 (groups A and B) and 20 (groups C and D) Sprague-Dawley rats, respectively. The animals were treated as follows: group A (control group) was given 0.9% NaCl i.m.; group B (LHRH group) D-Trp6-LHRH analogue (Decapeptyl); group C (LHRH + chemotherapy group) Decapeptyl + cyclophosphamide; group D (chemotherapy group) cyclophosphamide. The gonads were removed before therapy was initiated and on days 13, 52, and 182 after treatment and examined histologically. In addition, follicle-stimulating hormone (FSH) levels in the serum, a sensitive indicator of tubular damage, were determined. The most damaging effects of chemotherapy on histology and hormone levels were observed in the animals in group C, which were additionally treated with LHRH analogues. Therefore, it is not possible to protect the germinal epithelium of the rat with LHRH analogues during chemotherapy.

Animals↗
PubMed1991

Does the immunophenotype of renal cell carcinoma correlate with its clinical stage?

The following comparative study is an analysis of the clinical data, morphology and immunophenotype of 93 patients who have been operated on for renal cell carcinoma. We were able to show a close link between the histological grade and the occurrence of distant metastases: 33% of the patients with grade III tumours versus 11.5% of the patients with grade I tumours had developed metastasis by the time of the surgery. Histological subtyping per se did not give prognostic hints. Immunohistochemistry has revealed an inconsistent reaction pattern for the cytokeratin marker K11 (18/22). For proper diagnosis a panel of cytokeratin markers should be employed. The reaction patterns of monoclonal antibodies against the epidermal growth factor receptor (EGFR) and against myelomonocytic antigens in normal renal tissue (positive for the tubulus system) and in renal carcinoma indicate that renal cell carcinoma derive from the tubulus system. The proliferation marker Ki-67 correlates well with the histological grading. Although only a limited number of snap-frozen tumours have been investigated, this study indicates that EGFR is expressed by normal and by malignant renal tissue and that Ki-67 may serve as a prognostic marker.

Aged↗
PubMed1991

[Cavernosography using digital luminescence radiography (DLR) in the diagnosis of venous induced erectile function and of diseases of the corpus cavernosum].

Dynamic cavernosography is the most important technique for identifying and localizing venous leakage in erectile dysfunction. The use of digital radiography with a greater degree of tolerance in the exposure, a more dynamic signal, and a shorter exposure time can enhance the diagnostic value of conventional cavernosography. A further advantage of the method is the lower dosage required, which means that the gonads are exposed to less radiation. For 30 patients with erectile dysfunction and 7 other cases, conventional cavernosography images were compared with those obtained by this new method. The advantages of digital radiography are discussed.

Adult↗
PubMed1990

Bilateral renal angiomyolipoma: involvement of the contralateral kidney after 25 years--an unusual case.

The diagnosis of renal angiomyolipoma often poses problems, both clinically and pathohistologically. With the increasing refinement of imaging techniques it is becoming potentially possible to recognize these benign neoplasms by means of ultrasound, computed tomography and magnetic resonance imaging. Electron microscopy and histochemical methods are often necessary for the correct pathological diagnosis. The problems involved are presented on the basis of the case history of a patient who suffered from renal angiomyolipoma in both kidneys with an interval of 25 years. The first tumor was diagnosed histologically as a liposarcoma 25 years ago.

Female↗
PubMed1990

Xanthogranulomatous pyelonephritis associated with renal cell carcinoma. Report on two cases and review of the literature.

Xanthogranulomatous pyelonephritis is a rare and particularly aggressive variant of chronic destructive pyelonephritis. Even when all modern diagnostic possibilities are exhausted, it is often not possible to distinguish xanthogranulomatous pyelonephritis from a renal cell carcinoma preoperatively. In clinical practice false diagnoses are therefore frequent. The coexistence of xanthogranulomatous pyelonephritis and renal cell carcinoma is extremely rare. We report 2 such cases. In 1 case surgery was performed on the kidney affected by xanthogranulomatous pyelonephritis using a renal sparing technique.

Aged↗
PubMed1990

[Priapism following intracavernous injection of vasoactive substances as a urologic emergency].

From 1986 to 1989 papaverine was used alone or in combination with phentolamine in 165 patients in diagnosis and treatment of erectile dysfunction. In 14 patients a prolonged erection did occur after diagnostical introduction of SKAT therapy. Treatment consisted of intracavernous injection of 2-4 mg metaraminol, partly additional by puncture of cavernous bodies and evacuation of viscous blood. As single complication of metaraminol injection a hypertensive crisis could observed. A glando-cavernous shunt was not necessary in any case. After exact dosage adjustment the danger of drug-induced priapism is low.

Adult↗
PubMed1989

[Reducing the side effects of aggressive chemotherapy (cisplatin and epirubicin) with xenogenic peptides (factor AF2) in patients with hormone refractory metastatic prostate cancer. A prospective, randomized study].

The indication of a chemotherapy is advisable with patients who are suffering from a progressively metastasised, secondarily hormone refractory carcinoma of the prostate. In search of efficient chemotherapy protocols we combined cisplatin with epirubicin (PE scheme) in our clinic. Massive side effects of that aggressive chemotherapy scheme like gastro-intestinal trouble and myelotoxicity are the limiting factors of the scheme. With measures like reducing the dosage, delaying the next cycle, or breaking off the therapy the effective dosage can often not be achieved. The anti-emetics which are usually used today exclusively give anti-emetic protection. The additional administration of xenogenic peptides (Factor AF2) had additionally myeloprotective effect in former studies. In this study we examined whether, by additionally giving Factor AF2, the patients' subjective condition, and above all their hemogram, could be stabilised in order to achieve the effective dosage or dosage intensity. For that, the patients were prospectively randomised in two groups by means of a random selection board. The analysis of the data gained in the protocol showed that the additional administration of Factor AF2 improves the patients' subjective conditions significantly. Apart from that, we noticed a considerable reduction of the vomiting frequency. Concerning the objective measured parameters of the leukocytes, thrombocytes, erythrocytes, and the hemoglobin level, the significantly myeloprotective effect of Factor AF2 could be proved. Due to the fact that in the verum group there were considerably fewer cases of breaking off or delays of the treatment than in the control group, the effective dosage intensity could be achieved with a higher number of patients in that group.

Aged↗
PubMed1989

[Xanthogranulomatous pyelonephritis with fatal outcome in a 2-month-old infant].

A 2-month-old infant died of xanthogranulomatous pyelonephritis. Preoperatively pyonephrosis was suspected, because the child presented with a number of inflammatory, septic symptoms. Nephrectomy was performed and histopathology showed the kidney to be affected by xanthogranulomatous pyelonephritis. Postoperatively the child developed persistent attacks of fever and bronchopneumonia that led to his death with signs of pulmonary insufficiency.

Humans↗
PubMed1988

Monocyte/macrophage-directed antibodies Ki-M3 and Ki-M7 detect renal-cell carcinomas.

Monoclonal antibodies (MAbs) Ki-M3 and Ki-M7, which detect cells of the human monocyte/macrophage lineages, were tested using immunohistochemistry on a series of benign and malignant human tumors (n = 43). Positive staining was detected in all renal-cell carcinomas (n = 19 positive for both Ki-M3 and Ki-M7), a few cases of breast carcinoma (n = 6 for Ki-M3; n = 2 for Ki-M7), in 1 case each of prostatic carcinoma (Ki-M3) and prostatic adenoma (Ki-M3), and in 1 case of endometriosis (Ki-M3). In normal human kidney Ki-M3 and Ki-M7 reacted with proximal tubules and parts of the distal tubules and with the loop of Henle. The Ki-M3 and Ki-M7 MAbs proved useful in detecting renal-cell carcinomas and in distinguishing these tumors and their metastases from morphologically similar neoplasms: in addition, our study further hints that renal cell carcinomas are derived from tubular epithelial cells.

Antibodies, Monoclonal↗
PubMed1987

Diagnosis of urothelial tumor by ureterorenoscopy.

In the past, radiologically detected filling defects in the upper urinary tract were correctly interpretable only by means of cytological techniques. The introduction of ureterorenoscopy has provided a reliable method for the detection of tumors in the ureter and renal pelvis. In contrast to transurethral ureterolithotripsy, diagnostic ureterorenoscopy entails few complications. It thus fills a diagnostic gap and facilitates therapeutic planning. A report is presented on 15 patients with obscure hematuria, or unclear filling defects in the upper urinary tract. In 10 patients, the unequivocal diagnosis of urothelial carcinoma was endoscopically and bioptically established by ureterorenoscopy. Small nonradiopaque concrements were found in 3 cases. The origin of hemorrhage could not be determined in 2 patients.

Adult↗
PubMedDate not supplied

Publishitis.

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Education, Nursing↗
PubMedDate not supplied

A double innovation.

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Curriculum↗
PubMedDate not supplied

[What determines indications for surgery in over-90-year-old urologic patients?].

Whereas up to a few decades ago operations were performed in aged patients only for vital indications, today elective operations that aim at improving the quality of life are predominant. Urology in particular must deal with diseases that appear preferentially in older age groups. In our department of urology we have operated on 52 patients over 90 years of age in the past 10 years. The vast majority of patients had accompanying disorders, and in half of the patients their general condition was reduced or even poor at admission. Postoperatively there was only one cardiac death. All other patients were discharged in a satisfactory condition.

Aged↗