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Biomedical subjects

I Pascal

Publications and source records attributed to I Pascal.

10 recordsLinked to original sources
PubMed2005

[Asbestos: characteristics, properties, pathogenesis and sources of exposure].

Asbestos is a fibrous mineral that has been known since ancient times. It is widely used in industry due to its physical and chemical properties which make it highly suitable for this end. Asbestos is classified in two groups--serpentine and amphibole--depending on the curved or straight configuration of their fibres. Outstanding amongst its properties are its resistance to heat, wear, alkalis and acids, and its flexibility, amongst other characteristics, which make it a suitable material for use as insulation, in industrial textiles and in many other fields. The pathogenic risk of asbestos remaining for a long time in the pulmonary tissue has been known for many years; studies attribute it with alteration of the mucociliary activity of the host, macrophage activation and the freeing of inflammatory mediators as well as an increase in their oncogenic strength on association with tobacco and even some viruses.

Asbestosis↗
PubMed2005

[Workers in contact with asbestos: follow-up patterns].

Exposure to asbestos is associated with the development of benign and malign pleuropulmonary pathology. In recent years a broad set of regulations has been set in place, from the establishment of conditions in work involving exposure to asbestos to successive prohibitions on its use. Periodical medical checkups have been designed to detect these pathologies in exposed workers and, considering the long period of latency, they should also be carried out on retired workers or on those who in the past have suffered such exposure.

Asbestos↗
PubMed2005

[Building related ilness].

Following the changes carried out in recent years in buildings, such as ventilation systems, computers, etc., a series of diseases, that are related to this, have been described. This paper concentrates on the syndrome of the sick building, which is formed by a group of symptoms normally suffered by workers in the same "sick" building. This syndrome is related to its interior ambience, since the clinical manifestations appear some hours after entering the building and improves a few minutes after leaving this ambience. The origin is probably multifactorial: volatile airborne pollutants, the ventilation system, factors related to work organisation, or even dependent on the host. Since there is no single cause, we enumerate the risk factors in developing this syndrome as well as the steps for reaching a diagnosis and useful measures for preventing the sick building.

Humans↗
PubMed1999

[Asthma emergencies: can we lower the rate of readmission after discharge?].

INTRODUCTION: The rate of readmission among asthmatic emergency patients varies. In 1991 we observed a 9% rate of readmission following emergency room release. Studies of the number of readmissions or request for medical care are used as the basis for recommendations for releasing patients from hospital emergency care. No studies have assessed disease stability following release or factors related to stability. OBJECTIVES: To assess the course of disease and clinical stability of patients in the period immediately following release from emergency room care. To determine factors that might predict such stability. to determine the rate of readmission in the month following release after applying a treatment protocol and release criteria, with follow-up examination 72 h later. MATERIAL AND METHODS: Prospective, descriptive study with follow-up 72 h and one month after release. SETTING: Emergency and pneumology departments of a general hospital. PERIOD: six months. PATIENTS: 82 asthmatic patients released from the emergency room. RESULTS: Two patients (2.43% were readmitted. At the first follow-up visit (72 h) 81 patients (98.78%) were seen. At the second visit, 66 patients (80.5%) were examined. We observed stability in 70.3% of patients at 72 h and in 86.4% after on month. Stability was statistically related to whether peak expiratory flow greater or less than 70% (76.92% stable versus 46.66% unstable) (p < 0.05). No other clinical, epidemiological or treatment variables recorded upon release were found to influence stability. CONCLUSIONS: 1) A large proportion of patients are in stable condition 72 h after release. 2) When peak expiratory flow upon release is > 70%, stability is significantly increased 72 h later. 3) Our 2.43% rate of readmission one month after release is very low. 4) No differences in stability were seen to be related to oral corticoid prescription upon release.

Acute Disease↗
PubMed1999

[Mediastinal liposarcoma. A report of 2 cases].

Liposarcomas are malignant mesenchymal tumors whose primary location in the mediastinum is rare. We report two cases of mediastinal liposarcoma, describing the clinical signs and radiologic features found and the diagnostic procedures performed. The significance of histologic variability as a factor that conditions treatment and prognosis is underlined.

Adult↗
PubMed1999

[Evaluation of the ambulatory blood pressure monitor SAVE 33 model 2].

UNLABELLED: This work tests a new ambulatory blood pressure device: Save 33 II. The evaluation is conducted according to the phases II and IV of the British Hypertension Society (BHS) protocol: the phases I and III (before and after use) are not performed as this device has received the European quality label 'CE' that guarantees a +/- 3 mmHg accuracy before and after 10,000 simulated cycles. Two trained observers (hearing test and certification done according to the BHS recommendations) have performed 7 sequential BP measurements with conventional and automatic method, at the same arm, among 85 patients. The ranges of mean blood pressure are 78-203 mmHg, for SBP and 53-130 mmHg for DBP. RESULTS: The Save 33 II monitor satisfies the grade B of BHS evaluation for both systolic and diastolic pressures. This device also satisfies the Association for the Advancement of Medical Instrumentation (AAMI) protocol: mean difference between methods and standard deviation less than 5 +/- 8 mmHg: -2.7 +/- 6.8 mmHg for SBP and -0.86 +/- 6.6 mmHg for DBP. The in-use assessment is conform to BHS criteria for 20 recordings (less than 20% invalid values during day and night); the 5 other recordings have not enough night values, due to batteries failure (2 cases), sleeping discomfort (2 cases) and a cuff withdraw. CONCLUSION: This device, in the tested configuration, agrees the B grade of BHS and can be recommended for ambulatory blood pressure measurement.

Adolescent↗
PubMed1997

[Usefulness of computerized tomography in the study of pleural effusion with no presumed diagnosis].

To establish the diagnostic yield of computerized tomography (CT) in pleural effusions with no presumed diagnosis arising from standard clinical examination. A prospective protocol study enrolling all cases of effusion admitted to our hospital between January 1994 through July 1995 without a presumed diagnosis after initial testing that included thoracocentesis. Twenty-two patients were enrolled. All were given a CT scan as well as other complementary examinations considered appropriate and were referred to our outpatient clinic for follow-up. The CT images were read by an expert radiologist and their contribution was classified as "diagnostic", "suggestive" or "nil". A definitive etiologic diagnosis was achieved in 14 cases (8 neoplasms, 4 benign due to asbestos, 1 tuberculosis and 1 pulmonary embolism). The CT contribution was nil in 13 cases (59%), "diagnostic" in 6 (2 mesotheliomas, 1 hypernephroma, 1 lymphoma, 1 adenocarcinoma of the colon and another of the ovary) and "suggestive" in 3 (2 benign due to asbestos and 1 lymphoma). Positive information was obtained in 9 cases (41%). CT gives good yield in the investigation of pleural effusions with no presumed diagnosis and should be made available to this group of patients before other more invasive procedures are resorted to. It is especially useful for detecting neoplastic disease of the upper abdomen, mesothelioma and sings of unsuspected exposure to asbestos.

Aged↗
PubMed1997

[Skin tumor as presentation form of lung actinomycosis].

We report three cases of thoracic actinomycosis whose symptoms were cutaneous tumors on the thorax. Clinical signs and images are described, along with diagnostic procedures. The excellent outcome after antibiotic treatment, which must last at least 6 months, is emphasized as well as the need to keep this disease in mind when certain symptoms and images coincide.

Actinomycosis↗
PubMed1997

[Protected bacteriologic brushing in patients with severe copd].

To determine the presence of germs and their concentration in a group of patients with severe chronic obstructive pulmonary disease (COPD) (FEV1 < 50%), some of whom were in stable condition and others of whom were in acute phase. Twenty-six patients with severe COPD (14 stable and 12 acute phase) were enrolled. None had received prior antibiotic or corticoid treatment. The stable patients had no signs or symptoms of exacerbation, whereas the acute-phase patients had increased dyspnea, sputum volume and purulence. The patients received aerosol rather than liquid anesthesia when PSB sampling was performed. A PSB finding was considered positive at a level > or = 10(3) CFU/ml. There were no significant differences between the groups with respect to age, sex, proportion of smokers and ex-smokers or packs per year. The only spirometric measure that was significantly different was (FEV1/FVC, which was lower in the acute-phase group (p < 0.05). Positive PSB findings were recorded for 57.1% of the stable patients and for 66.7% of the acute-phase patients (p = NS). H. influenzae was the microorganism found most often in both groups. The mean CFU/ml level was 8,625 in stable patients and 17,375 in acute-phase patients (p = NS). A large proportion of stable patients (57.1%) with severe COPD harbor significant concentrations of germs as revealed by PSB sampling. Germ concentrations were found in a non significantly greater number of acute-phase patients, confirming the lack of congruence between clinical status and bacteriological condition.

Aged↗