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Biomedical subjects

I Petkov

Publications and source records attributed to I Petkov.

At least 19 recordsLinked to original sources
PubMed1996

[Thymectomy in myasthenia gravis---experience with 173 surgical patients].

Over a 13-year period, 173 patients with myasthenia gravis--69 per cent men and 31 per cent women--undergo operative treatment in the clinic of thoracic surgery with oncology at the Military Medical Academy--Sofia. Most patients present generalized form of the disease. The operation consists in longitudinal sternotomy. In the last few years, a new approach to preoperative preparation and postoperative treatment of the patients is used. As the result of strict long-term postoperative monitoring, plasmapheresis application, immunomodulation and adequate intensive care, the rate of complications is greatly reduced with not a single fatal outcome being recorded.

Adult↗
PubMed1995

[The use of continuous epidural analgesia in the combined treatment of chronic arterial obstruction in the lower extremities].

Experience had with the application of continuous epidural analgesia (CEDA) in the complex treatment of 33 patients with advanced stage of chronic arterial obstruction in the lower extremities is presented. In fourteen of them (42.4 per cent) CEDA is effected using implantable catheterization system "Periplant", and in the remainder 19 (57.6 per cent)--through nonimplantable "Periflex++". The technique of application of the systems is described. The therapeutic effect is estimated on the basis of: 1) quantitative evaluation of pain perception by a 5-point rating system, 2) acral skin thermometry, and 3) Doppler ultrasound tonometry. Changes in the parameters listed are compared with their counterparts in a control group of 33 patients, and subjected to statistical processing. Proceeding from the obtained results the inference is reached that CEDA is very effective in terms of main relief, and improves perfusion of the ischemic limbs. The implantable catheterization systems contribute to the patient's comfort for rather prolonged period of time, and reduce infection hazards in the vicinity of the spinal cord.

Aged↗
PubMed1994

[The morphological characteristics of the circulating blood after massive reinfusion in operative surgery].

Intraoperative autologous blood extravasation represents an adequate biogenic medium for prompt and complete blood volume compensation following acute hemorrhage. The efficiency of the procedure is closely related to the functional characteristics of the ATS applied and its potential adaptation to the operative field. Over a 5-year period, autologous blood reinfusion is done in 151 patients with acute intraoperative hemorrhage associated with various types of operative interventions. The hemogram is analyzed in 32 cases undergoing reconstructive surgery of arterial vessels, with massive intraoperative hemorrhage and reinfusion (exceeding 25 per cent of the circulating volume). The quantity of AB represents 92.7 per cent of the blood loss volume; reinfusion is effected using the patient's own ATS. The circulating erythron level (its binding portion) remains within reference limits throughout the full post-reinfusion period; a tendency towards complete correlative dependence between the values of Hb, Er, Ht and the volume of reinfusion done intraoperatively is outlined (r = 0.84-0.92; p < 0.05-0.001). Free hemoglobin concentration in the transfusion product is low (66.8 +/- 24.2 mg/100 ml blood), while in the post-reinfusion circulating blood it quickly returns to normal, at 2 hours--in 87.5 per cent of the samples, and at 6 hours--in 100 per cent (r = 0.66-0.80; p > 0.001). The minimal morphologic changes in AB upon its deposition and reinfusion warrant the assumption that it is the most suitable transfusion medium, contributing to normalization of the hematologic indicators of acute hemorrhage during operative surgery.

Adult↗
PubMed1987

[Biopharmaceutical and clinico-pharmacological research on the intramammary preparation Cephamasten].

An animal drug formula, Cephamasten, for intramammary application in the treatment of mastitis-affected cows, ewes, and goats in the lactation period was worked out on the base of microbiologic, technologic, biopharmaceutic, and clinico-pharmacologic studies. Its active ingredient was the Pharmachim cephalexin-monohydrate. The consistence of Cephamasten has proved suitable for intracisternal introduction. It is tolerated well within the udder of cows, and it rapidly releases the antibiotic incorporated in it. The milk of the treated quarters has proved free from cephalexin after the 72nd hour of the last infusion. Cephamasten has shown high effectiveness in the treatment both of the preclinical and of the acute clinical mastitis. In the first case best results were obtained with the twofold treatment at a 24-hour interval, and in the second case--with the sixfold treatment at 12-hour intervals (intracisternal introduction of the preparation). In the case of generalized mastitis, in dependence on the severity of the process Cephamasten is to be applied at 4-6-12 intervals along with frequent milking and the parenteral application of other agents.

Animals↗
PubMed1987

[Cytological research on the vaginal mucosa in cows with estrous cycle disorders].

Cytologic investigations were carried out of a total of 140 cows with regard to the vaginal mucosa in the event of disturbed functions in the course of the sexual cycle: hypofunction of the ovaries (71 animals), persisting yellow bodies (34 animals), and estral and postestral cases of metrorrhagia (35 animals). Chamov's trichromatic method was employed to stain the smears and Véznik's cytogramme method--to carry out the recordings. It was found that in the case of ovarian hypofunction the mixed type of cell pictures prevailed (47.8 per cent), followed by the estrogenic type (39.4 per cent), and the progesterone type (12.6 per cent). In the case of persisting corpora lutea the mixed type of cell picture prevailed too--64.7 per cent, while the estrogenic and progesterone types were 17.6 per cent. Featuring in the postestral and estral metrorrhagia was the estrogenic type of cell picture (51.4 per cent), while the mixed type accounted for 45.7 per cent of the cases, and the progesterone one--for 2.8 per cent. It is suggested to use the cytovaginal method in combination with the routinely employed clinical and laboratory tests for the overall evaluation of the condition of the genital system in cows.

Animals↗
PubMed1984

[Cocks with experimentally induced acute typhoid].

Acute typhoid infection was induced in cocks of the New Hampshire breed at the age of 14 months within the period of intense productivity. Bacteriologically, there were in the viscera of cocks died of the acute infection organisms of Salmonella gallinarum--the isolates were from the heart, liver, spleen, and testis, while in the viscera of infected birds that were killed no such organisms were isolated. Histologically, there were necrobiotic and degenerative lesions in the epithelial cells of the seminiferous tubuli as well as disturbances in the process of spermiogenesis. The morphologic changes seen in the parenchymal organs were analogous with those that have been demonstrated so far. Cytologically, the semen of the infected cocks presented pathologically changes spermatozoa and anomalies of their head and tail; a large number of erythrocytes and leukocytes were also found.

Acute Disease↗
PubMed1979

[Toxicological studies of the technical phosphate of Pharmachem tylosin].

Studies on the acute, subchronic and chronic toxicity of technical tylosine phosphate (TTP) with 50 UI/mg activity, produced by Pharmachim were carried out. It was established that TTP does not cause lethality in white rats following application of 20, in white mice--of 40, in chickens--of 30 and in pigs--of 2 g/kg body weight. Long term application to the rations--of chickens for 40 days, in doses of 20, 40 and 60 g/kg fodder (=1.3 and 5 ED100) and of pigs for 32 days in doses of 2.6 and 10 g/kg fodder (=1.3 and 5 ED100) stimulates gain in weight of both species by 2-11.5% and improves the utilization of nutrition by 4.5-12.5% without any unfavourable effect on the clinical-biochemical composition of the blood and the structure and development of inner organs.

Animals↗
PubMed1975

Skin manifestations associated with tumours of the brain.

In a 4-year period seventy-seven patients with tumours of the brain were investigated for skin manifestations. These were observed in twenty-four (31-2%) and fall into three main groups: Pruritus. Thirteen patients complained of pruritus. Most characteristic is the pruritus of the nostrils, which was observed in six patients. It can be extremely severe and is a sign of an advanced tumour. Pigmentary disorders were observed in seven patients. In two, vitiligo appeared simultaneously with the brain tumour symptoms. In the others, hyperpigmentation appeared on the face later in the course of the disease. Hyperkeratotic changes were manifest in four patients. Two had a mild hyperkeratosis of the palms and soles. The other two developed in addition an ichthyosiform atrophy of the skin. The possible pathogenesis of the skin manifestations associated with brain tumours is discussed.

Adolescent↗