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Biomedical subjects

I Picáns

Publications and source records attributed to I Picáns.

5 recordsLinked to original sources
PubMed1996

Betahistine-induced bronchospasm.

Betahistine is a cerebral vasodilator structurally related to histamine, which stimulates H1 bronchial and vascular receptors. We report the case of a 28-year-old female patient who presented bronchospasm during treatment with betahistine hydrochloride. The prick test was negative. The oral challenge test showed bronchospasm and urticarial lesions. To the best of our knowledge, this is the first case of betahistine-induced bronchospasm reported in the literature. The study carried out failed to reveal the mechanism of the reaction.

Adult↗
PubMedDate not supplied

Mononucleosis-like illness as a manifestation of carbamazepine-induced anticonvulsant hypersensitivity syndrome.

We describe a case of infectious mononucleosis-like as a manifestation of carbamazepine-induced anticonvulsant hypersensitivity syndrome. Patch testing to carbamazepine and phenytoin were positive and negative to phenobarbital. Our results suggest a cell mediated type of immune response in the pathogenesis of this syndrome. Patch testing may be helpful in the diagnosis of anticonvulsant hypersensitivity syndrome caused by carbamazepine.

Adult↗
PubMedDate not supplied

Fixed drug eruption from amoxycillin.

We present a case of fixed drug eruption on the genital mucosa induced by amoxycillin. Topical provocation was carried out, applying amoxycilin (10% pet) on the glans penis. No reaction was observed. Oral challenge with amoxycillin was followed by pruritic erythema on the glans penis 6 hours after the intake of 125 mg. The study of cross-reactivity to other betalactams showed good tolerance of phenoxymethyl-penicillin, which shares an identical nuclear structure with amoxycillin. The patient also tolerated cephadroxil, a cephalosporin with a side chain identical to that of amoxycillin. On reviewing the literature we have only found three reports of fixed drug eruption fue to amoxycillin.

Adult↗