Biomedical subjects

I Podreka

Publications and source records attributed to I Podreka.

77 records · Page 5Linked to original sources

PubMed1976

Scintigraphy in lymphomas and leukemia of the brain.

Scintigraphy with 99mTc-pertechnetate made it possible to detect focal brain lesions in 4 patients with primary malignant lymphomas of the brain, one patient with CNS involvement with lymphatic immunoblastoma, one patient with Sézary syndrome (mycosis fungoides and T cell leukemia) and one child with a space occupying infiltration of myeloblastic leukemia. The scintigraphic results were verified by morphological data from biopsy or autopsy.

Aged↗

PubMedDate not supplied

Regional brain function in hallucinations: a study of regional cerebral blood flow with 99m-Tc-HMPAO-SPECT in patients with auditory hallucinations, tactile hallucinations, and normal controls.

From the supposition that there exists a possible connection between certain psychopathological symptoms, and/or syndromes (e.g., hallucinations) and regional cerebral dysfunction, patients suffering from auditory and tactile hallucinations were investigated, in a symptom-oriented study, using the method of technetium-99m-Hexamethyl-propylenamine Oxime (99m-Tc-HMPAO)-Single Photon Emission Computed Tomography (SPECT) and compared with normal controls. The results support Jackson's hypothesis to the effect that hallucinatory phenomena will primarily occur when the normally inhibitive influence of the upper cortical centers over the lower brain structures diminishes, resulting in relative hyperactivity in the basal regions. In addition to the brain activity-changes generally observed in hallucinating patients, it was possible to identify regional cerebral blood flow (rCBF)-distribution patterns characteristic in certain forms of hallucinatory phenomena, i.e., a significant increase of activity in the hippocampal regions (including hippocampus, parahippocampus, and amygdala) only in patients with auditory hallucinations, and a significant reduction of rCBF in the inferior temporal regions in patients with tactile hallucinations.

Adult↗

PubMedDate not supplied

SPECT and MR imaging in herpes simplex encephalitis.

Two cases of necrotizing herpes simplex encephalitis (HSE) were investigated with 99mTc-hexamethylpropyleneamineoxime (HMPAO) SPECT and MR. The clinical course was compared with the neuroimaging results. In the acute stage, the increased HMPAO uptake matched the MR hyperintense signal in the limbic temporal lobe and in the basal ganglia. Protracted inflammation was accompanied by persistently high HMPAO uptake. The sequelae of HSE were characterized by decreased HMPAO uptake and postnecrotic widening of the temporal horns. The "limbic" pattern recognized in both SPECT and MR reflects the basic pathophysiology and neuropathology of HSE. Both methods may be useful in the diagnosis and follow-up of HSE.

Contrast Media↗

PubMedDate not supplied

Atraumatic CBF measurement with the scintillation camera. Comparison with intracarotid rCBF values.

A scintillation camera connected to a dedicated computer system was employed for atraumatic CBF measurements in 43 patients after intravenous injection of 35 to 55 mCi 133Xe in saline solution. To validate this method results were compared to flow values in the same patients measured after intracarotid Xe injection. While the correlation between i.c. and i.v. values was not satisfactory when a high resolution collimator was used, a high sensitivity collimator improved count rates and yielded CBF values after i.v. in agreement with those from i.c. studies. For mean hemispheric flow, the correlation coefficient between the methods was 0.93 and the standard deviation of the i.v. value for a given i.c. value was 2.93. The correlation coefficients for 13 regions were between 0.55 and 0.85. These correlation coefficients are comparable to those obtained with multidetector equipment. Ischemic regions could be accurately detected, and the flow values in these areas were significantly related (r = 0.81). Values in 6 healthy volunteers were in the normal range reported by other investigators. One disadvantage of the camera is that measurements are restricted to one hemisphere, but selection of recording areas is not limited to the position of single probes and may be changed during analysis of the data permitting analysis of flow in irregularly-shaped, pathologically-perfused regions. The results indicate that the scintillation camera is a useful tool for clinical rCBF studies.

Adolescent↗

PubMedDate not supplied

Flow and compartmental weight in relation to the cours of stroke.

Using a scintillation camera system, hemispheric and regional cerebral blood flow was measured repeatedly during the course after a stroke. In 20 patients who improved clinically mean hemispheric and regional flow and relative weight of rapidly perfused compartment increased, while these values decreased in 15 patients, on an average, whose clinical condition deteriorated or did not change. The changes of flow and relative weight were significantly different between the two groups. Futhermore, the relationship between changes in clinical condition, scored according to a rating scale, and changes in flow and compartmental weight was proved by significant Spearman rank correlation coefficients. In six cases hyperperfused areas in locations of disturbed neurological function were observed; these areas were found to be ischemic at measurements done early and late in the cours after the stroke. This type of hyperperfusion was related to beneficial prognosis. The results indicate a shift of tissue form fast to slowly cleared compartment after a cerebrovascular attack. If tissue morphology is not entirely destroyed, recovery might occur; this results in an increase of recorded weight of rapidly clearing compartments, which correlates to the clinical course.

Adolescent↗