Biomedical subjects

I Poiata

Publications and source records attributed to I Poiata.

7 recordsLinked to original sources

PubMed1999

[The ocular hypotensive effect of the combination of latanoprost with dorzolamide].

OBJECTIVE: To analyze the hypotensive effect and ocular tolerance produced by the association of a topic carbonic anhidraze inhibitor (dorzolamide--Trusopt) and a prostaglandin derivative (latanoprost--Xalatan) in the treatment of the hypertensive glaucomas. MATERIAL AND METHOD: The study includes two steps: STEP I: A double-blind randomized prospective study which includes 32 eyes with primary open angle glaucoma, divided in two groups: group A, in which Trusopt is administrated for 7 days and then Xalatan is associated for another 7 days and group B, in which the order is reversed: for the first 7 days only Xalatan is administrated and then for another 7 days, Trusopt is associated in the treatment. The intraocular pressure and the secondary effects were assessed daily. STEP II: An open clinical trial that includes 47 eyes with different types of glaucomas in which the combination Trusopt + Xalatan was used for 90 days. The intraocular pressure and the secondary effects were assessed weekly. RESULTS: In the first study (step I) the combination Trusopt + Xalatan induces an additive type of ocular hypotensive effect which is not depend by the order of the two drugs used in the beginning of the treatment (37.49% for group A and 39.16% for group B); In the clinical trial for medium term (step II), the combination Trusopt + Xalatan results in a decrease of IOP, which varies between 27.94% and 37.02% and was stable on the whole period of the study; We observed the following secondary effects: conjunctival hyperemia (6 cases), burning sensation (3 cases), foreign body sensation (1 case), itching (2 cases) and hazing (1 case). CONCLUSIONS: The association Trusopt + Xalatan results in an additive ocular hypotensive effect which was stable on the whole period of the study (medium term); The ocular tolerance of this combination is good and was not followed by the interruption of the treatment.

Aged↗

PubMed1999

[Cataract surgery in diabetic patients].

PURPOSE: Analysis of functional results, per- and postoperative complications after cataract surgery in diabetic patients. MATERIAL AND METHOD: Retrospective study including 100 non-diabetic patients and 50 patients with type II diabetes, with extracapsular extraction and IOL implantation in the postoperator chamber followed for 10.3-7.3 months postoperative complications. RESULTS: Postoperative visual acuity was lower in diabetic patients (0.317 +/- 0.24) versus non-diabetic patients (0.634 +/- 0.30); postoperative visual acuity was lower in diabetic patients without retinopathy (0.437 +/- 0.26) versus diabetic patients with non-proliferative retinopathy (0.348 +/- 0.26) or diabetic proliferative retinopathy (0.116 +/- 0.11); the incidence of per- and postoperative complications (early and late) is higher in diabetic patients compared with the control group. CONCLUSIONS: Cataract surgery in diabetic patients is followed by higher rate of per- and postoperative complications. The postoperative functional result is dependent, in principal, on the retinal status of the diabetic patient and, secondary, on the per- and postoperative complications.

Aged↗

PubMed1998

[The effect of chronic beta-blocker treatment on the evolution of primary open-angle glaucoma].

UNLABELLED: Comparative analysis of the results of the trabeculectomy in primary open-angle glaucoma (POAG) when it was chosen as a primary treatment and when was preceded by chronic use of topic beta-blockers. MATERIAL AND METHOD: Retrospective study of 59 patients (group A) with primary trabeculectomy and 42 patients (group B) with topic beta-blockers treatment for at least 3 years subsequent to trabeculectomy was performed. The average postoperative follow-up period was 3 years and 5 months. RESULTS: Postoperative IOP lowering was similar in both groups; There are no statistical differences between group A and B concerning stationary cases (76.27% in group A and 75.4% in group B), regressive cases (6.8% and 7.14% respectively) and progressive cases (18.6% and 17.9% respectively); Preoperative and postoperative complication rates were similar in the 2 groups. CONCLUSIONS: The chronic beta-blockers use does not influence the evolution of operated POAG.

Adrenergic beta-Antagonists↗

PubMed1997

[Intra- and postoperative use of 5-fluorouracil in the surgical treatment of refractory glaucoma].

OBJECTIVE: Analysis of the safety and efficiency of various modalities of 5-FU administration in the surgery of refractory glaucoma. MATERIALS AND METHOD: A prospective, randomized study including 36 patients with refractory glaucoma who received 5-FU in the following protocols: group A (10 patients)--intraoperative application of 50 mg 5-FU, group B (12 patients)--postoperative subconjunctival injections of 5 mg 5-FU, group C (14 patients)--intra and postoperative administration of 5-FU. Mean follow-up interval is 6 months. RESULTS: Last controlled intraocular pressure is lower in C group patients (13.92 mmHg) versus group A and group B patients (< or = 15.7 mmHg). The real therapeutic success rate (intraocular pressure < or = 15 mmHg) and the qualified success rate (intraocular pressure < or = 21 mmHg) are higher in group C (85.7% and 92.8% respectively) as compared with group A and group B (50% and 82% respectively). The rate of side-effects in highest in group B and lowest in group C. CONCLUSIONS: Association of intra and postoperative use of 5-FU in refractory glaucoma increases the rate of therapeutic success and a lower incidence of side-effects.

Antimetabolites↗

PubMed1997

[Primary trabeculectomy in the surgery of primary open angle glaucoma].

OBJECTIVE: Comparative analysis of the results of trabeculectomy in the surgery of primary open angle glaucoma (POAG) as the primary therapeutical approach and after the medical treatment failure. MATERIALS AND METHOD: Retrospective study including two therapeutical groups: A (59 patients) with primary trabeculectomy; and B (60 patients) with trabeculectomy following a medical treatment failure; mean follow-up period was 3 years and 5 months. RESULTS: Postoperative drop in intraocular pressure was similar in the two groups; there is no statistical significant difference between the two groups regarding stationary disease (76.27% in group A, versus 73.33% in group B), regressive disease (6.8% versus 6.7% respectively) and progressive disease (18.6% in group A, versus 21.6% in group B). At an intraocular pressure < or = 21 mmHg 13.6% of glaucoma cases do progress. The rate of peroperative and postoperative complications is similar in the two groups. CONCLUSIONS: The prior medical treatment of glaucoma doesn't affect the evolution of operated POAG. Primary trabeculectomy is indicated for non-compliant patients and for patients in whom administration of combined medical treatment for short time periods doesn't lower the intraocular pressure at safe levels. Surgical treatment has the advantage of an important and constant lowering of the intraocular pressure which is an absolute requirement for an efficient control of advanced glaucoma.

Aged↗

PubMedDate not supplied

[The surgical results in traumatic cataract].

The retrospective analysis of the postoperative course in 204 traumatic cataracts (140 isolated, simple cataracts and 64 aggravated ones) showed an apparent functional improvement in the simple cases (preoperative and postoperative visual acuity 0.0139 and 0.8520, respectively); the incidence of postoperative detachment of retina was of 4.9%, that of postoperative endophthalmitis that of cystoid macular edema of 3.2%; complications more commonly occurred in aggravated traumatic cataracts and partially accounted for the poorer functional results. During the investigated interval (1988-1992) a rapid shift to extracapsular cataract extraction and posterior chamber lens implants was made. The crystalline grafts preserved binocular vision in 92% of the cases and contact lens in 50% of the cases. Lens implant remains a matchless solution for the visual rehabilitation of the patients with aphakia.

Cataract↗

PubMedDate not supplied

[Late postcontusion secondary glaucoma].

The investigation of 33 patients with late postcontusional glaucoma subjected to surgery and followed up for 25 +/- 8.24 months has revealed: the interval accident-surgery is shorter in the close-angle combined forms; the essential mechanisms responsible for glaucoma occurrence are: the alteration of trabecular meshwork (for open-angle glaucoma) and pupillary block (for close angle glaucoma); simple cases required antiglaucoma surgery (trabeculectomy, peripheral iridectomy) and the mixed ones required combined (trabeculectomy, lens extraction, lens implant) or sequential surgeries (antiglaucoma surgery, vitrectomy etc); the glaucomatous process was stopped in 83.4% of the open-angle glaucoma cases and progressed in 23.5% of the close-angle glaucoma cases; the functional improvements post antiglaucoma surgery combined with removal of opacities are lessened by the higher frequency of severe per- and post-operative complication.

Contusions↗