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Biomedical subjects

I Prerovský

Publications and source records attributed to I Prerovský.

At least 19 recordsLinked to original sources
PubMed1991

HLA and venous thrombosis: a prospective study.

The frequency of venous thrombosis diagnosed by the fibrinogen uptake test and ultrasound in relation to HLA typing was examined in a prospective study of 154 patients undergoing total hip replacement. The results demonstrate an association between venous thrombosis and the presence of HLA Cw4 and B35 (being in a linkage disequilibrium with Cw4) (Cw4 34.4% and B35 27.3%, relative risk 2.531 and 1.935 respectively). These results suggest that the presence of HLA Cw4 can be regarded as one of laboratory risk factors of venous thrombosis.

Adult↗
PubMed1990

Vasoconstriction in patients after heart transplantation.

We have the values of rest and maximal blood flow and of venous compliance in the forearm in three groups of patients: those undergoing orthotopic heart transplantation, those with severe cardiac insufficiency, and a control group. The findings suggest the presence of arteriolo- as well as venoconstriction in transplanted patients. This, however, was less pronounced than in the patients with heart failure. Neither the values of maximal blood flow nor those of minimal peripheral resistance in the forearm obtained after a 5-minute ischaemic insult differed significantly between the patients after heart transplantation and the controls. Thus, arteriolar constriction can be removed by this insult in patients after transplantation.

Blood Pressure↗
PubMed1989

[Central and peripheral circulation in patients after orthotopic transplantation of the heart].

Heart transplantation in human medicine is a unique model which makes it possible to study circulatory changes in complete denervation of the heart. The authors examined repeatedly the central and peripheral haemodynamics after orthotopic heart transplantation (OTS) in 11 patients (11 males, 1 female; mean age 44 +/- 4 years) following an interval of three months to four years after the operation. The values of central haemodynamics at rest varied in the majority within the normal range. After a load, in patients after OTS the heart rate rises only slowly. There is an abnormal rise of the filling pressure in both ventricles which leads also to an abnormal rise of pressure in the pulmonary artery with regard to flow. The cardiac output and stroke volume increase adequately. The peripheral circulation is characterized by persisting vasoconstriction in the area of resistant vessels and the venous circulation. The above changes reflect the different regulation of cardiac output after complete denervation of the heart by transplantation when the magnitude of the cardiac output is controlled mostly by the Frank-Starling mechanism. Changes of the tonus of the peripheral circulation contribute under these conditions to the maintenance of an adequate output.

Adult↗
PubMed1989

The effect of hydroxyethylrutoside and its combination with acetylsalicylic acid in patients with obliterative atherosclerosis.

The effect of 7-mono-hydroxyethylrutoside and its combination with acetylsalicylic acid was evaluated in a controlled clinical trial, performed in 105 patients with obliterative atherosclerosis of the lower limbs, and using non-invasive measurement of peripheral haemodynamic parameters--blood flow during reactive hyperaemia and ankle systolic blood pressure. Patients, randomized into three groups, received either placebo or 7-mono-hydroxyethylrutoside alone or in combination with acetylsalicylic acid for 12 months. The placebo group showed a decrease in maximum calf blood flow and a decrease in ankle systolic pressure. Administration of 7-mono-hydroxyethylrutoside did not lead to any significant changes in systolic pressure but there was a decrease in the maximum calf blood flow. There were no statistically significant changes in patients receiving the 7-mono-hydroxyethylrutoside and acetylsalicylic acid combination who, by contrast, showed a tendency to increased values of the parameters measured.

Adult↗
PubMed1989

Endothelial lesion in hypertension.

A method for indicating latent endothelial lesion based on circulating endothelial cell count after methionine challenge was used in a group of hypertensives and in healthy controls. A significantly increased cell count was found in hypertensives.

Cell Count↗
PubMed1989

Blood flow through the brachial artery at different temperatures in patients with Raynaud's phenomenon.

Blood flow through the brachial and radial artery at different temperatures and during reactive hyperaemia was measured in 23 patients with Raynaud's phenomenon (9 patients with Raynaud's disease, 7 - Raynaud's syndrome with thoracic outlet syndrome (TOS), and 8 - Raynaud's syndrome and scleroderma), and 11 control subjects. Blood flow was determined by an ALVAR pulse-wave Doppler system enabling measurement of vessel diameter and blood flow rate. The measurements suggest that the blood flow through brachial artery reflects the changes of blood flow through the hand immersed in water of different temperatures. Maximum vasoconstriction was the same in all groups of Raynaud's phenomenon. The lowest blood flow at higher temperatures and during reactive hyperaemia was found in patients with scleroderma, whereas in the group of TOS and partly in patients with Raynaud's disease one can suspect only functional changes.

Adolescent↗
PubMed1988

Deep vein thrombosis and its prevention in patients with acute myocardial infarction.

The incidence of venous thrombosis (VT) detected by 125I-labelled fibrinogen was followed in 408 patients with acute myocardial infarction (AMI). Patients were randomized into three groups: a group receiving small doses of heparin (2 X 5000 u. subcutaneously/24 h), and an exercise group (dorsal and plantar flexion of the foot for one minute each hour). VT was present in 13.6% of the control group, in 9% of the group with mini-heparin (an insignificant difference), and in 5.1% of the group with moderate exercise (p less than 0.05). VT was statistically significantly more frequent in patients with acute MI who had heart failure, thrombosis in their medical history, had varices and were non-smokers. The results indicate that even moderate exercise of the lower limbs decreases significantly the incidence of VT in patients with AMI.

Acute Disease↗
PubMed1986

Capillary filtration coefficient in the forearm of patients with essential hypertension.

The capillary filtration coefficient (CFC) in the forearm was followed in patients with essential hypertension and compared with controls, using the method of venous occlusion plethysmography and simultaneous recording of intravenous pressure in the measured segment of the extremity. Arterial blood-pressure was obtained in the contralateral arm by auscultation. The CFC averaged 0.0039 +/- 0.009 ml/100 ml/min/mmHg and 0.0095 +/- 0.0018 ml/100 ml/min/mmHg in hypertensives and controls respectively. The relation between CFC and arterial blood-pressure values was inversely non-linear. The results suggest reduction of the capillary area due to hypertension and possibly functional or structural changes in the microcirculatory bed accompanying systemic blood-pressure increase.

Adult↗
PubMed1985

The effect of venostasis on several laboratory parameters in patients with predisposition to venous thromboembolism.

A series of laboratory tests was performed in 25 patients with recurrent venous thromboembolism as compared with 14 healthy person. The tests were combined with venostasis. The values of haematocrit, low-shear viscosity and fibrinogen were significantly higher in the preocclusion samples of the group with recurrent thromboembolism than in the controls. Venostasis did not increase the sensitivity of the tests. Platelet counts, euglobulin fibrinolysis, antithrombin III and total plasma proteins were not significantly increased either in preocclusion or in postocclusion samples as compared with the controls.

Adolescent↗
PubMed1983

Transcapillary escape rate of albumin in juvenile hypertension.

The transcapillary escape rate of albumin was studied in 24 juvenile hypertensives and in 13 controls on the basis of the radioactivities determined in the blood during 60 min after i.v. injection of human 131I-labelled albumin. In addition, the central haemodynamics of all hypertensive subjects was examined at rest and during exercise. The patients were grouped according to their pressure during the investigation at rest. The group whose mean arterial pressure did not exceed 100 mmHg, thus being within the range of normotension, did not exhibit a significant deviation from controls. The group with mean arterial pressure exceeding this limit (corresponding to the range of borderline hypertension) showed a significantly higher escape rate of albumin (9.3 +/- 5.0%/h) than controls (5.2 +/- 1.6%/h). The albumin escape rate was significantly correlated to the mean pulmonary artery pressure during exercise but not to the remaining central haemodynamic parameters at rest or during exercise. No difference was seen in the magnitude of plasma volumes of juvenile hypertensives and controls. The findings suggest that secondary changes of capillary functions are present already in the early stages of hypertension.

Adult↗