alpha1-Antitrypsin deficiency and hepatocellular cancer.
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Adult↗
Biomedical subjects
I Prinsloo
Publications and source records attributed to I Prinsloo.
Progressive systemic sclerosis complicated by diffuse pulmonary haemorrhage.
A case is reported of progressive systemic sclerosis with pulmonary fibrosis which was complicated by recurrent haemoptyses due to diffuse pulmonary haemorrhage. We have found no other report of this association. The haemorrhage finally remitted after treatment was started with 40 mg prednisone daily, though previously spontaneous remissions had occurred.
Hemoptysis↗
Alpha1-antitrypsin deficiency--an association with hepatic malignancy.
A 70-year-old man with homozygous alpha1-antitrypsin deficiency (AATD) (Pi-ZZ phenotype) at tutopsy was found to have a hepatocellular carcinoma and hepatic fibrosis, pulmonary emphysema, and cor pulmonale. Characteristic cytoplasmic inclusion bodies, with identical histochemical and ultrastructural features, were detected in both normal and malignant liver cells. It is suggested that AATD may precede malignancy, since this is the eleventh case report of this association.
Aged↗