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Biomedical subjects

I R Kramer

Publications and source records attributed to I R Kramer.

At least 37 records · Page 2Linked to original sources
PubMed1974

Further studies on lesions of the oral mucosa using computer-aided analyses of histological features.

The histological feature of various "white lesions" of the oral mucosa have been subjected to computer-aided analyses, with the objectives of improving the accuracy of diagnosis, and the more reliable identification of the lesions most likely to progress to carcinoma.Previous reports on these studies have shown the potential usefulness of cluster and discriminant analyses, both for the classification of cases into their diagnostic groups, and for the identification of the tissue changes most useful in discriminating between one disease and another.The present report describes two extensions of this work. The first was the application of a scoring technique, based on discriminant analysis, to a new series of cases. In this series, the computer "correctly" identified 36 out of 41 that had been diagnosed as lichen planus by conventional methods. The second part of the study involved the calculation of the importance of each histological variable in defining the characteristics of groups of cases placed into different diagnostic groups or clusters by the computer. From these calculations, it was possible to depict the histological characteristics of each group in diagrammatic form.

Biopsy↗
PubMed1971

The mitotic values for the epithelium in oral keratoses and lichen planus.

In biopsies from the oral mucosa of 235 cases in which the diagnosis was lichen planus, keratosis or leukoplakia, mitotic values were calculated for the stratum basale (M.V. basal) and the stratum spinosum (M.V. spinous). The mean M.V. basal was significantly different from the mean M.V. spinous in the keratosis and leukoplakia groups, but not in the lichen planus group. Within the keratosis and leukoplakia groups, M.V. basal and M.V. spinous were significantly correlated. When each of the mean M.V.s was compared with the M.V.s for the other diagnostic groups, various significant differences were found. The M.V.s were examined in relation to the type of keratinization, the presence of acanthosis or atrophy, and the patient's age, but the M.V.s were not significantly related to these features.

Acantholysis↗