Biomedical subjects
Publications and source records attributed to I Rab.
Monophasic action potentials were recorded in 7 mongrel dogs, endocavitarily, from heart in situ and from the epicardial surface with open chest thus revealing the characteristic configuration of the different chambers. The duration of the monophasic action potential showed a good correlation with the cycle length, demonstrated during endocavitary electrostimulation.
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From a collectivity of 17,256 subjects below the age of 30 years, 80 subjects with labile hypertension (LH) were selected. The LH subjects were subjected to exercise test and the response of arterial blood pressure (BP) was followed up. The data obtained were compared with similar determinations carried out in a group of normotensive subjects. The mean value of systolic blood pressure (SBP) on exercise in the normal subjects was 171.0 +/- 2.9 mmHg and that of diastolic blood pressure (DBP) was 77.5 + 1.5 mmHg. The LH subjects presented, on exercise increases of both SBP and DBP in 35 cases (43.7%), increase of only SBP in 10 cases (12.5%) and "normal" type response in 35 cases (43.7%). In these subjects the mean value of SBP, on exercise, was 191.0 +/- 2.6 mmHg (p less than 0.001 as compared with the normal) and that of DBP was 90.0 +/- 1.9 mmHg (p less than 0.001 as compared with the normal). The above data proved that the LH subjects represented a group distinct from the normal subjects. The LH subjects presented a bimodal percent distribution of SBP and DBP on exercise, suggesting the existence of two subgroups one with "normal" type BP response the other with "hypertensive" type response. The BP response to exercise represents a simple test for the detection of abnormal BP increases. The authors consider as fully justified a longitudinal study of LH subjects. The exercise test might have a predictive value in detecting the early signs of essential hypertension.
From the 33 patients with infective endocarditis (IE) hospitalized in the 1st Clinic of Internal Diseases, Timişoara between 1981 and 1984, in 5 (4 men and one woman) ranging in age from 21 to 52 years (mean 38) cardiac surgery was indicated and aortic (3) and mitral (2) valve replacements were performed. Valve replacement was performed for: 1) rapid/slow progressive hemodynamic deterioration with intractable congestive heart failure associated with ruptured chordae on posterior leaflet of mitral value (1 case); perforated aortic cusp (1 case); 2) prosthesis endocarditis (1 case); 3) precocious recurrence of IE (1 case); 4) uncontrollable infections (1 case). Echocardiography was helpful in all the cases by permitting recognition and evaluation of the preexistent lesions, and by the supplying of characteristic vegetations (all echocardiographic findings were confirmed by open heart surgery). Likewise it proved an accurate method in assessing pre- and post-operative left ventricular performance. In conclusion it is considered that early valve surgery in IE is indicated in hemodynamic deterioration, prosthetic endocarditis or impossibility to control septicemia. Echocardiography is the most useful noninvasive method for the pre- and postoperative evaluation of the patients investigated.
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