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Biomedical subjects

I Ragnhult

Publications and source records attributed to I Ragnhult.

14 recordsLinked to original sources
PubMed1990

Relationship between kerma and treatment volume in intracavitary radiation therapy.

Data on 200 patients with carcinoma of the uterine cervix irradiated with afterloading brachytherapy using various high dose rate source configurations have been evaluated with respect to the total reference air kerma and the treatment volume as well as other volumes of interest. The experimental results showed good correlation between kerma and volume, and have also been discussed theoretically for the single-source, double-source and triple-source configurations. The possibility of using the demonstrated kerma-volume relationships for simple estimation of volumes enables us to select the appropriate treatment plan for the individual patient and to evaluate the results of the treatment.

Adsorption↗
PubMed1987

Male breast carcinoma. II. A study of the total material reported to the Swedish Cancer Registry 1958-1967 with respect to treatment, prognostic factors and survival.

The complete material of male breast cancer, 166 cases, reported to the Swedish Cancer Registry in 1958-1967 is described and analyzed concerning different prognostic parameters, treatment methods and survival. Age at diagnosis, axillary lymph node status and tumour size all had significant prognostic importance in a multivariate analysis with axillary lymph node status as the strongest factor. Histologic malignancy grade was strongly correlated to axillary lymph node status and tumour size and thus to prognosis, but did not seem to be an independent prognostic factor. The primary treatment methods were quite heterogeneous and were obviously influenced by both age of the patient and clinical tumour status. No significant correlation was found between type of primary treatment and survival, but due to the retrospective nature of the study no definite conclusion could be drawn. Radical mastectomy seemed, however, to give fewer loco-regional recurrences than both modified radical mastectomy and simple mastectomy. Very few patients in the present series had received radiation therapy in adequate doses. The material gave some indications that orchiectomy might prolong survival in patients with recurrent or generalized disease.

Age Factors↗
PubMed1983

High dose rate afterloading treatment in carcinoma of the uterine cervix using an individual planning and reconstruction system.

The results of intracavitary radiation treatment of 100 cases of cervical carcinoma stage I B and II A with a high dose rate afterloading system are reported. To increase treatment precision an individual method was used with definition of the target and with a detailed three-dimensional computer planning system. A Wertheim operation followed intracavitary treatment and postoperative external irradiation was only given to cases with positive nodes. Residual tumor was found to the same extent as with the former manual radium treatment. Besides having achieved full radiation protection of the staff, radiation reactions among patients were almost eliminated.

Adenocarcinoma↗
PubMed1983

Computed tomography measurements of the cervix and distances to the bladder and rectum in intracavitary radiation treatment of gynaecological cancer.

Improved knowledge of the topography of target and adjacent organs in intracavitary irradiation of gynaecological tumours is needed when a high dose rate afterloading system with good precision is used. To get this information, 16 patients with small carcinomas were examined by computed tomography scan with applicators inserted. The thickness of the vesico and rectovaginal septa was measured. In the ten cervical carcinomas the minimum thickness was 4 mm. In the six early corpus carcinomas the vesicovaginal septum thickness was 7 to 9 mm while the rectovaginal septum thickness was 5 to 7 mm. Measurement of the cervical diameter seems to be valuable and can give information about suitable intracavitary target dimensions. In this way overtreatment of the bladder and rectum can be avoided and a more precise dose can be delivered to the entire target volume.

Brachytherapy↗
PubMed1981

Radiation-induced parathyroid adenomas and thyroid tumors in rats.

Parathyroid morphology was studied in 45 irradiated and 37 control rats. The irradiated rats received a single parathyroid dose of about 6.5 gray. The rats were killed and autopsied 14 months later. The radiation resulted in fibrosis and depression in weight of the parathyroids. In irradiated rats eleven parathyroid adenomas and four thyroid tumors were found. In control rats no tumor occurred in either parathyroid or thyroid glands. All irradiated rats, including those with a parathyroid adenoma, were normocalcemic.

Adenoma↗
PubMed1978

Occurrence of previous neck radiotherapy among patients with associated non-medullary thyroid carcinoma and parathyroid adenoma or hyperplasia.

Sixteen consecutive patients with co-existent non-medullary thyroid carcinoma and parathyroid adenoma or hyperplasia are reported. Ten of these patients had earlier been treated with external radiation in the neck region. The estimated absorbed dose varied between 5 and 23 gray. The diagnosis of thyroid carcinoma and hyperparathyroidism (HPT) was established 36 years (average) after exposure to radiation. The findings are in accordance with the hypothesis that radiation can serve as an etiological factor in the development of associated thyroid carcinoma and HPT.

Adenocarcinoma↗
PubMed1977

Hyperparathyroidism in persons treated with X-rays for tuberculous cervical adenitis.

Follow-up examinations of one hundred persons treated with x-rays for tuberculous adenitis between 1930 and 1946 have been carried out to determine if there is an increased incidence of hyperparathyroidism (HPT) after radiation exposure. Neck explorations were done in patients with hypercalcemia and signs and symptoms compatible with HPT. Individuals with thyroid masses were also operated upon when examination of fine needle specimens gave suspicions of malignancy. Eleven subjects were found to have developed parathyroid adenoma or hyperplasia. Four other individuals have hypercalcaemia but are asymptomatic. The mean absorbed dose in the parthyroid glands varied between 75 and 2,200 rads. Six individuals received more than 1,200 rads; four of them later developed HPT, while no HPT occurred below a dose of 300 rads. The high incidence of HPT among patients who had been heavily exposed to radiation suggests a cause and effect relationship between radiation treatment and development of HPT.

Adenoma↗
PubMed1976

Autonomous hyperparathyroidism: a possible late complication of neck radiotherapy.

In a series of 170 patients operated on for autonomous hyperparathyroidism (HPT) during a four-year period ending 1974, 24 patients (14%) had, earlier in life, received radiation therapy to the neck region for various benign conditions. Treatment records were traced in 19 cases. The estimates of absorbed dose in the parathyroids ranged from 200 to 3 000 rad. Eighteen patients had their first course of treatment in childhood or early adult life. The diagnosis of HPT was established in these patients 42 years (average) after exposure to radiation. Six patients who were irradiated after the age of 48 had an average time lapse of 12 years before the diagnosis of HPT was made. The occurrence of signs and symptoms related to HPT was similar in exposed and non-exposed patients. The high incidence of previous neck radiotherapy in our series suggests that radiation may be a contributory factor in the development of HPT.

Adult↗