Biomedical subjects

I Rautakorpi

Publications and source records attributed to I Rautakorpi.

4 recordsLinked to original sources

PubMed1977

Antibodies against herpes simplex virus type 1 subunit antigens in patients with trigeminal neuralgia and controls.

Serum IgG antibody levels against herpes simplex virus (HSV) type 1 subunit (capsid, envelope, and excreted) antigens detected with radioimmunoassay were compared in 25 patients with trigeminal neuralgia and their age- and sex-matched controls. No significant differences were found between the patients and controls, either in the distribution of the antibody titers or in the mean titers against any of the subunit antigens tested. In 6 patients HSV antibody titers were tested before and after trigeminal root section; no significant changes were observed.

Adult↗

PubMed1976

Parkinson's disease treated with Sinemet or Madopar. A controlled multicenter trial.

92 patients with Parkinson's disease not previously treated with levodopa were considered as eligible for this triple-blind trial. Patients were allocated at random to treatment with either levodopa + benserazide ratio 4:1 (Madopar) or levodopa + carbidopa ratio 10:1 (Sinemet) using dosage schedules recommended by the manufacturers which they had to adhere to for 6 months. Unless prohibitive side-effects occurred daily maximum dosage of 800 mg levodopa + 200 mg benserazide respectively 1,500 mg levodopa + 150 mg carbidopa were obtained after 6 weeks and 3 weeks, respectively. The effect of the two schedules on the Parkinsonian symptoms were equal and appeared equally fast. The frequency of gastrointestinal side-effects and involuntary movements were significantly higher and more severe for Sinemet than for Madopar. These side effects are usually symptoms of levodopa overdosing, but whether or not a different dosage schedule with Sinemet would have given fewer side-effects without concurrent lower efficacy remains open to speculation. The treatment schedules did not differ with regard to other side-effects and influence on blood pressure. Neither treatment seemed to influence liver function, renal function and hematological parameters in a statistically way.

Aged↗

PubMed1976

[Essential tremor].

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Adrenergic beta-Antagonists↗

PubMed1976

L-Tryptophan administration in man: effects on gonadotrophin, growth hormone and cortisol secretion and on sexual motivation.

Long-lasting administration of L-tryptophan in neurologic patients caused a slight reduction of plasma luteinizing hormone levels without modifications of sexual motivation. Plasma follicle stimulating hormone concentrations were not altered by L-tryptophan. Short-lasting loading of L-tryptophan caused a statistically significant increase of plasma growth hormone levels, and a fall of plasma cortisol values in neurologic patients without neuroendocrine disorders. The pattern of plasma cortisol response to L-tryptophan loading was different in patients with neuroendocrine disorders. Plasma gonadotrophins seemed to be slightly reduced after the L-tryptophan loading.

Depression, Chemical↗