PubMed Health⌕ Search

Biomedical subjects

I Raz

Publications and source records attributed to I Raz.

At least 109 records · Page 6Linked to original sources
PubMed1988

Influence of moderate exercise on glucose homeostasis and serum testosterone in young men with low HDL-cholesterol level.

Fifty-five healthy sedentary non smoking and non obese 24-26-year-old men with a low serum concentration of HDL-cholesterol were selected for a study of the effect of nine weeks of exercise on glucose homeostasis, and blood testosterone. The participants were randomized into two groups. Twenty-eight subjects were assigned to a nine-week program of submaximal aerobic exercise three times weekly, while 27 were assigned to a non exercising control group. The improvement in physical fitness was assessed by change in estimated oxygen consumption (EVO2 max) that was increased by 15% in the exercise group (p less than 0.001), but remained unchanged in the control group. During the study the body weight of both groups remained essentially unchanged. There was a significant reduction of mean plasma fructosamine in the exercise group, and non significant reduction in serum insulin. Serum testosterone, glycohemoglobin and HDL-cholesterol were not influenced by exercise, while serum triglycerides were significantly reduced.

Adult↗
PubMed1988

Influence of chronic diabetes on tissue and blood cells status of zinc, copper, and chromium in the rat.

The influence of chronic diabetes on zinc, copper and chromium status in the urine, plasma, liver, kidney, bone, muscle, lymphocytes and erythrocytes was investigated in rats 180 days after streptozotocin injection, in comparison to age matched normal rats. The concentration and tissue content of zinc and copper were increased significantly in the liver, femur, erythrocyte and lymphocyte of the diabetic rats in addition to an increase in their urinary loss. In contrast, the concentration of zinc, copper and chromium in the kidney of the diabetic rats and the concentration of copper in the muscle and of chromium in the liver of the diabetic rats were similar to those of the normal rats. There was also a marked deficiency of zinc in the muscle and of chromium in the bone of the diabetic rats. The potential significance of altered trace metal metabolism during long term changes in endocrine status, and the possible explanation and significance of the variable concentrations of essential metals in different organs of streptozotocin induced chronic diabetic rats is discussed. The importance of erythrocyte and leukocyte zinc concentration as a mirror to their relative concentration in other tissue of animals and humans with type I diabetes is raised.

Animals↗
PubMed1988

Comparative pharmacokinetic analysis of novel sustained-release dosage forms of pentoxifylline in healthy subjects.

The pharmacokinetics and relative bioavailability of pentoxifylline, from a new sustained-release formulation (Oxopurin) and from a standard sustained-release formulation (Trental-400), were compared in 8 healthy adult male volunteers. After a single oral dose of 400 mg Oxopurin, a mean maximal plasma concentration (Cmax) of 164 +/- 62 micrograms/l was obtained after 2.2 h (tmax). After an identical dose of Trental-400, a peak plasma concentration of 123 +/- 33 micrograms/l was obtained after 2.4 h. Plasma levels of pentoxifylline were determined by a new HPLC assay which was developed as part of this study and makes possible monitoring plasma levels of pentoxifylline for 14 h after a single dose. The mean relative bioavailability of pentoxifylline from Oxopurin was 1.30 +/- 0.19 relative to that of Trental-400. As the rate and the extent of absorption of pentoxifylline was not significantly different after the administration of the two investigated formulations, it can be concluded that Oxopurin is bioequivalent to Trental-400.

Adult↗
PubMed1988

Comparative pharmacokinetic analysis of a novel sustained-release dosage form of diclofenac sodium in healthy subjects.

The pharmacokinetics and relative bioavailability of diclofenac sodium from a new sustained-release formulation (Effekton-100) and from a standard sustained-release formulation (Voltaren-Retard) were compared in 11 healthy adult male volunteers. After a single oral dose of 100 mg Effekton-100, a mean maximal plasma concentration (Cmax) of 497 +/- 120 ng/ml was obtained after 7.4 h (tmax). After an identical dose of Voltaren-Retard, a peak plasma concentration of 654 +/- 329 ng/ml was obtained after 6.4 h. Plasma levels of diclofenac were determined by a new HPLC assay which was developed as part of this study and makes possible monitoring plasma levels of diclofenac for 24 h after a single dose. The mean bioavailability of diclofenac from Effekton-100 was 0.97 +/- 0.28 relative to that of Voltaren-Retard. As the rate and the extent of absorption of diclofenac sodium was not significantly different after the administration of the two investigated formulations, it can be concluded that Effekton-100 is bioequivalent to Voltaren-Retard.

Adult↗
PubMed1987

Thymoma presenting as a superior vena cava syndrome remission following therapy.

A 45-year-old male developed myasthenia gravis 8 years ago. He received prednisone for 3 years, and resumed complete clinical remission. Five years later, he was admitted with obstruction of the superior vena cava. Invasive thymoma was diagnosed by chest X-ray and an open lung biopsy. Radiation followed by combination chemotherapy with cyclophosphamide, vincristine, and prednisone induced a complete remission. The patient remained disease-free for more than 20 months after the first admission to our department. To the best of our knowledge, superior vena cava syndrome as the presenting symptom of thymoma has never been reported previously.

Combined Modality Therapy↗
PubMed1987

Shigella sonnei myocarditis.

A 19-year-old male was admitted to our department because of high fever, abdominal pain, and diarrhea. Electrocardiogram (ECG) on admission revealed diffuse ST-T changes which persisted for 5 days. Stool culture grew Shigella sonnei. We conclude that the infection with Shigella sonnei was the cause for these findings which were most probably due to myocarditis. To the best of our knowledge myocarditis as a complication of shigella infestation has never been reported.

Adult↗
PubMed1985

Acute bilateral brachial plexus neuritis associated with hypersensitivity vasculitis. A case report and review of literature.

The occurrence of brachial plexus neuritis during the acute phase of vasculitis is uncommon. We describe a patient with a long history of rhinitis and a recent onset of asthma, who developed purpuric skin lesions, abdominal pain, eosinophilia and brachial neuritis along with evidence of sacral plexus neuropathy. High dose steroids and cyclophosphamide induced a remission. He stopped all medications after 3 years and after 6 years the patient has some fixed minimal residual neurological deficit. The importance of aggressive therapy in treating extensive polyneuropathy during the acute phase of hypersensitivity vasculitis is raised. A possible cytotoxic role of eosinophils in the pathological process is suggested.

Acute Disease↗
PubMed1985

Hairy cell leukemia associated with carcinoma: report of two patients and review of the literature.

The association of carcinoma and hairy cell leukemia (HCL) in two patients is recorded. One of the cases was a 58-year-old male who developed carcinoma of the kidney, while the second patient was a 48-year-old woman with carcinoma in the breast. This rare association is probably coincidental, as it is not described in most of the larger reported series of patients with HCL. It is of interest to note that the first patient had received radiation therapy thirty years before the diagnosis of HCL and carcinoma was made.

Adenocarcinoma↗
PubMed1985

Identification of synthetic, voiced stop-consonants by hearing-impaired listeners.

The identification of synthetic, voiced stop consonants changing in place of articulation was investigated in 26 normal-hearing listeners and 16 hearing-impaired listeners who reported difficulties in speech understanding, but attained high speech discrimination scores on standard test materials. Two place continua (each containing 13 stimuli changing from /ba/ to /da/ and /ga/) were employed: a continuum in which place was cued by an initial noise burst and formant transitions, and a continuum in which place was cued by formant transitions alone. All normal listeners exhibited categorical and highly consistent identification for both stimulus continua. For the hearing-impaired listeners, identification was somewhat less consistent for the burst-and-transition stimuli, and much poorer for the transition-only stimuli. Similar differences were observed when comparing the responses of 4 subjects with a unilateral hearing loss when the stimuli were presented to their normal and impaired ears, and 2 subjects with a unilateral, sudden-onset hearing loss with recovered pure-tone sensitivity.

Adolescent↗
PubMed1985

An unusual case of rheumatic pneumonia.

A 14-year-old boy developed severe respiratory failure during the course of acute rheumatic fever. The results of all microbiological studies were normal. Rheumatic carditis or left ventricular failure was excluded by routine examinations, catheterization of the right side of the heart, and multiple-gated radionuclide ventriculography. The patient recovered completely after a course of high-dose prednisone. To our knowledge, this is the first well-documented case of rheumatic pneumonia in which the lung disease could be attributed to the rheumatic disease and not to a pathologic heart condition.

Acute Disease↗
PubMed1985

Effect of sustained-release on the pharmacokinetics of theophylline in healthy subjects.

The effect of sustained-release on the pharmacokinetics of theophylline was examined by comparing two sustained-release formulations (Theo-Dur and Theotard) to an oral solution and i.v. preparation of the drug. Drug-level monitoring was performed by an HPLC assay. The absorption profiles of the three oral formulations were pharmacokinetically analyzed by using the Loo-Riegelman procedure. The absorption of theophylline after the administration of the Theo-Dur and Theotard was found to be of an apparent zero-order kinetics.

Adult↗
PubMed1984

Coexistence of myelomonocytic leukemia and monoclonal gammopathy or myeloma. Simultaneous presentation in three patients.

The coexistence of monoclonal gammopathy or myeloma and nonlymphoblastic leukemia is reported in three untreated patients. One patient had IgG kappa myeloma and monoblastic leukemia, whereas the two others had IgA paraprotein in association with chronic granulocytic and acute myelomonoblastic leukemia, respectively. Simultaneous presentation of monoclonal gammopathy or myeloma and nonlymphoblastic leukemia is rare, and this report reviews the possible pathogenesis of this phenomena.

Aged↗
PubMed1984

CNS involvement by non-Hodgkin's lymphoma. Response to a standard therapeutic protocol.

Treatment results of 31 episodes of CNS involvement by malignant lymphoma diagnosed in 24 patients were studied. Leptomeningeal involvement occurred in 16 patients, intracerebral invasion in eight patients, and epidural cord compression in seven patients. Twelve patients with leptomeningeal involvement treated with intraventricular methotrexate sodium achieved complete CSF remission and ten patients' conditions improved neurologically. Five of the patients with epidural cord compression were ambulatory following treatment. Complete resolution of intracerebral lymphoma was documented by computed tomographic scan in four patients. The overall median survival was nine months, eight months for leptomeningeal involvement, five months for intracerebral lymphoma, and 12 months for patients with cord compression. Our results suggest that all forms of CNS lymphoma usually respond well to therapy, life span is prolonged, and is free of CNS disease until patients die of uncontrolled systemic lymphoma.

Adolescent↗
PubMed1984

Pancytopenia with hypercellular bone marrow--a possible paraneoplastic syndrome in carcinoma of the lung: a report of three cases.

Three patients with idiopathic pancytopenia and hypercellular bone marrow who developed carcinoma of the lung within two years of diagnosis are reported. All three patients had macrocytic anemia associated with a megaloblastic marrow in the presence of normal serum vitamin B12 and folic acid levels. Neutropenia with monocytosis, elevated serum muramidase and LAP scores, and increased fetal hemoglobin levels were also found. In all cases Ham's tests were negative with a normal bone marrow karyotype. In all three patients, pancytopenia due to myelodysplasia, a probable preleukemic state, was diagnosed initially prior to the appearance of carcinoma of the lung. One of the patients showed improved leukocyte and platelet counts during chemotherapy, while the other two died before chemotherapy could be administered. In the light of the above findings we suggest that carcinoma of the lung may be the cause of a paraneoplastic syndrome with pancytopenia, particularly in patients with a hypercellular marrow with a normal karyotype.

Adenocarcinoma↗
PubMed1984

Comparative pharmacokinetic analysis of a novel sustained-release dosage form of theophylline in humans.

The pharmacokinetics and relative bioavailability of theophylline from a new sustained-release formulation ( Theotard ) and from a standard sustained-release formulation (Theo-Dur) were compared in 6 healthy, adult, male volunteers. After a single oral dose of 300 mg Theotard , a mean maximal plasma concentration ( Cbmax of 3.49 +/- 1.05 mg/l was obtained after 8 h (tmax). After an identical dose of Theo-Dur, a peak plasma concentration of 4.68 +/- 1.33 mg/l was obtained after 6.33 h. The mean relative bioavailability of theophylline from Theotard was 1.02 +/- 0.16 relative to that of Theo-Dur. In 5 of the volunteers the Theotard formulation exhibited a more prolonged and uniform absorption rate and yielded more sustained plasma levels.

Adult↗
PubMed1984

Pharmacokinetics of valpromide after oral administration of a solution and a tablet to healthy volunteers.

The pharmacokinetics of valpromide, a primary amide of valproic acid, was investigated in 6 healthy, adult male volunteers, each of whom was given 900 mg as a marketed, enteric-coated tablet and a solution. Valpromide was biotransformed to valproic acid after the administration of the tablet and the solution with a bioavailability of 0.79 +/- 0.24 and 0.77 +/- 0.12, respectively, relative to a marketed tablet of valproic acid. The absorption of valpromide was not rate-limited by dissolution. As a solid, nonhygroscopic, neutral prodrug of valproic acid, valpromide may be a good alternative to valproic acid and sodium valproate.

Adult↗