PubMed Health⌕ Search

Biomedical subjects

I Requena

Publications and source records attributed to I Requena.

At least 19 recordsLinked to original sources
PubMed1998

[Clinical pseudo-peripheral presentation of cerebral lesions].

Small size cerebral lesions, located strategically, can determine the presence of sensitive and motor signs limited to a part of an extremity, clinically suggesting peripheral nervous system affectation, determining erroneous diagnostic and therapeutic decisions. We present 5 patients initially diagnosed of peripheral nervous system pathology, which were finally diagnosed of cerebral lesions (2 lacunar infarcts, multiple sclerosis, progressive multifocal leucoencephalopaty, multicentric astrocytoma). In all, clinical examination disclosed incongruous distribution of the sensitive manifestations and myotatic reflexes were present. CT studies were normal in three patients whereas MRI showed lesions in all cases. Lesions were smaller than 1.5 cm in diameter (greater in the case of multicentric astrocytoma), and were subcortically located in the opposite cerebral hemisphere to the affected extremity. Sensitivomotor signs restricted to an extremity not concordant with a nervous or radicular distribution and with presentation of myotatic reflexes, make it necessary to look for a central nervous system lesion. Lesion will be located in the opposite cerebral hemisphere and MRI will be the elective complementary exam.

Adult↗
PubMed1998

[Long chronic course of hemiparkinson-plus with l-dopa maintained response].

UNLABELLED: OBJECTIVE AND CLINICAL CASE: We describe and present a video film of a patient with a hemiparkinsonian illness associated with hemidystonia and pyramidalism, which responded to continuous L-Dopa treatment for twenty years, with no fluctuation or deterioration at the end of the dose-effect. CT and MR studies were normal. CONCLUSIONS: The characteristics of this case with probable static unilateral dysfunction, basically presynaptic, of the nigrostriate via, make it reasonable to include it in the hemiparkinson-hemiatrophy group.

Aged↗
PubMed1998

[From writer's cramp to butcher's spasms: a case of interprofessional dystonia].

INTRODUCTION: Occupational or professional dystonia is a focal motor dystonic disorder which affect motor programs necessaries for the exercise of the patient's profession. Clinical case. A patient with writer's cramp in the childhood presented at the age of 22 years a new dystonia, which we name 'butcher's spasm', giving rise to a laboral incapacity. Neurological exam was normal except for right arm distal (writer's cramp) and proximal dystonias (butcher's cramp), with intentional tremor in the upper extremities. We classified, after complementary exams, the disease as idiopathic. CONCLUSIONS: Idiopathic focal dystonias can progress to segmentary or multifocal dystonias, and, in exceptional cases as ours, can interfere with two different professional activities.

Adult↗
PubMed1997

Senile chorea: a multicenter prospective study.

Senile chorea (SC) is characterized by the presence of late onset, generalized chorea with no family history and no dementia. It is unclear whether it is a distinct clinical entity or represents late onset Huntington's disease (HD) with an undetected family history. In order to clarify this issue, we carried out a prospective, multicenter study of suspected cases of SC. Since 1994 we identified six cases that met clinical criteria for SC. Their study included routine lab tests, cerebral MRI, neuropsychological assessment, and lastly gene IT15 analysis. An abnormal expansion of the (CAG)n repeat was found in three patients. Although there were no criteria for dementia, most neuropsychological tests revealed mild to moderate deficits, particularly in visuospatial and prefrontal tasks, m all six patients, those that were finally diagnosed as having late onset "sporadic" HD, but also in patients that finally had SC. This study provides further evidence on the existence of SC; however, the distinction from late onset "sporadic" HD seems not to be possible on clinical grounds unless a genetic study is carried out. Some cases of suspected "SC" have late onset "sporadic" HD.

Age of Onset↗
PubMed1996

[Hemiballismus heralding thrombosis of the basilar artery].

We present a patient with top-of-the-basilar syndrome that was preceded by hemiballismus and progressed to coma and tetraplegia. Magnetic resonance imaging showed extensive infarction in the basilar artery territory. Cerebral angiography confirmed basilar artery obstruction. The patient died in spite of anticoagulation therapy.

Aged↗
PubMed1996

[Pseudotumor cerebri secondary to cerebral venous defects not identified by magnetic resonance].

Pseudotumour cerebri is the name of a syndrome characterized by headache and papilloedema, with normal cerebral CT/MR studies and CSF with a high pressure and normal laboratory findings. We describe four patients who fulfilled the diagnostic criteria of this condition (including normal 0.5T MR studies). They all had cerebral angiograms showing minor abnormalities localized to the level of the superior longitudinal sinus. All improved on treatment with anticoagulants and steroids. In view of these findings we consider that in cases of pseudotumour cerebri without a clear aetiological factor, an angio MR study should be done, or if this technique is not available, a cerebral angiogram should be done, to exclude cerebral venous drainage defects.

Adult↗
PubMed1995

Acute respiratory failure as the first sign of Arnold-Chiari malformation associated with syringomyelia.

We report a rare case of acute respiratory failure in a previously asymptomatic patient showing clinical signs of inferior cranial nerve palsy together with weakness and muscular atrophy of the upper limbs. Magnetic resonance imaging revealed Arnold-Chiari malformation associated with platybasia, basilar impression, syringomyelia and Klippel-Feil syndrome. Episodes of apnoea required tracheostomy and recurred upon tentative closure of the tracheostome, but remitted upon decompression of the posterior fossa. This case involved both obstructive mechanisms and dysfunction of the respiratory centre. Patients with respiratory failure not explained by pulmonary pathology should be checked for underlying neurological disease.

Abnormalities, Multiple↗
PubMed1994

[Disorders of neuronal migration: clinical and radiological signs in 21 patients].

We describe 21 patients affected by neuronal migration disorders. The main clinical manifestations were epilepsy, hemiparesis with hemiatrophy and psychomotor retardation. The neuronal migration disorders most frequently diagnosed were various forms of heterotopia and schizencephaly. Magnetic resonance imaging was more sensitive and specific that computed tomography in the diagnosis of these disorders. Schizencephaly correlates well with hemiparesis and hemiatrophy, as does nodular heterotopia with focal epilepsy and diffuse neuronal migration disorders with severe encephalopathies.

Adolescent↗
PubMed1991

[Hypertensive encephalopathy: contribution of magnetic resonance].

We report a patient with hypertensive encephalopathy and we analyze his clinical and neurological imaging peculiarities. Computed tomography showed hypodense corticosubcortical lesions, whereas magnetic resonance scan disclosed extensive, wholly reversible enhanced signal lesions due to cerebral edema.

Brain Diseases↗
PubMed1991

Clear cell squamous cell carcinoma. A histologic, immunohistologic, and ultrastructural study.

Squamous cell carcinomas (SCCs) usually show a standard histopathologic picture only varying with regard to their degree of differentiation. The authors describe a case of clear cell SCC that was studied by light and electron microscopy. The clear cells showed an empty cytoplasm that was periodic acid-Schiff and alcian blue negative. By electron microscopy these cytoplasms consisted of empty spaces and were not surrounded by membranes, which would be consistent with lipid vacuoles. The differential diagnosis of this uncommon variant of SCC requires consideration of other clear cell tumors.

Adenocarcinoma↗
PubMed1991

Cavernomas of the central nervous system: clinical and neuroimaging manifestations in 47 patients.

Forty seven cases of central nervous system cavernous angioma (21 males and 26 females) are described. The main clinical signs were epilepsy and brainstem syndromes. Digital subtraction intra-arterial angiography, when used, failed to reveal cavernoma. CT detected many of the lesions, but the most successful supplementary diagnostic procedure was MRI which produces highly characteristic images of cavernous angioma. The diagnosis of cavernous angioma was confirmed in the 18 cases in which the tumour was removed surgically.

Adolescent↗
PubMed1990

Trichogenic trichoblastoma. An unusual neoplasm of hair germ.

Tumors of hair germ are a very rare group of primary cutaneous neoplasms that have been divided into two groups: epithelial and mesenchymal. Epithelial neoplasms of hair germ are further subdivided into those that are purely epithelial (trichoblastomas) and into epithelial neoplasms with mesenchymal components that may cause inductive changes toward the earliest phase of hair follicle differentiation (trichoblastic fibroma) or a more advanced and complete hair follicle formation (trichogenic trichoblastoma). We herein report an ulcerated trichogenic trichoblastoma whose epithelial and mesenchymal components recapitulated the formation of numerous primitive dermal papillae of the hair bulb because there were numerous strands of small polygonal epithelial cells that delimited areas of a dense and abundantly cellular connective tissue in a hair papilla-like pattern.

Adult↗
PubMedDate not supplied

A silver staining method for the detection of polymorphic proteins in minute bloodstains after isoelectric focusing.

A silver staining method has been developed to study polymorphic proteins in bloodstains after isoelectric focusing. This method is highly sensitive and permits the detection of polymorphic proteins (i.e. alpha 1-antitrypsin, Gc and Tf C subtypes) in bloodstains as small as 0.2 microliter or less. The method is simple and reproducible and can be used after immunofixation. Blood stains can be identified after longer storage periods than is possible by using conventional staining methods.

Blood Proteins↗