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Biomedical subjects

I Rosa

Publications and source records attributed to I Rosa.

8 recordsLinked to original sources
PubMed1999

[Acute hepatitis in the course of cyclosporine therapy of Crohn's disease].

BACKGROUND: Cyclosporin is used for the treatment of corticosteroid-resistant inflammatory bowel disease. Secondary liver disease is a risk. CASE REPORT: Acute hepatitis with predominant major transaminase elevation occurred in a patient treated with cyclosporin for corticosteroid-resistant Crohnś disease. No viral, alcoholic, autoimmune or metabolic cause could be incriminated. Complete cure was achieved after withdrawal of cyclosporin. DISCUSSION: Only one case of cholestatic hepatitis has been reported in chronic inflammatory bowel disease. Cyclosporin was the probable cause in our case as other causes of acute hepatitis were ruled out and withdrawal led to cure. Cyclosporin can induce abnormal liver tests in 25% of cases. If reducing dose does not lead to improvement, it may be necessary to discontinue cyclosporin. Regular liver tests would thus be required for patients given cyclosporin for chronic inflammatory bowel disease.

Adult↗
PubMed1999

[Ticlopidine-induced lymphocytic colitis].

Lymphocytic colitis is a clinico-pathological syndrome characterized by chronic diarrhea, normal endoscopy, diffuse colonic mucosal inflammatory changes. Collagenous colitis is defined by a thickening of the collagen plate. The etiology is unknown but immune disorders have been frequently associated with it and it has been linked with the taking of certain drugs such as nonsteroïd anti-inflammatory drugs or veinotonics. We are reporting a case of microscopic colitis associating both lymphocytic and collagenous colitis, wich induced chronic diarrhea in a 65-year-old man. It appeared after he had taken ticlopidine. Diarrhea stopped after he had discontinuated ticlopidine, and recurred after he resumed taking the drug. Histological damages from lymphocytic colitis improved six month after he had stopped taking ticlopidine. Chronic diarrhea induced by ticlopidine might be caused by lymphocytic colitis.

Aged↗
PubMed1999

[Herpetic esophagitis in human immunodeficiency virus non infected patients].

We report five cases of herpetic esophagitis in human immunodeficiency virus non-infected patients. Herpetic esophagitis is a frequent infection in immunocompromised patients. However, sixty four cases of herpetic esophagitis have been reported in immunocompetent patients. The infection presents non-specific esophageal symptoms. Diagnosis relies on esophageal histology and viral cultures. Treatment by acyclovir is recommended to prevent severe complications. This infection is probably underestimated in immunocompetent hosts but seems to be more frequent in patients with severe illness that can be responsible for transitory immunodeficiency. Biopsies of esophageal lesions should be systematically performed in these patients.

Adult↗
PubMed1996

[Mesenteric panniculitis simulating Crohn disease].

Mesenteric panniculitis is a rare disease involving the adipose tissue of the mesentery. We report a case of a 27-year-old woman with mesenteric panniculitis, who presented clinical and radiological features mimicking Crohn's disease. In the outcome, she presented a small bowel perforation, unusual in this pathology, and an annexial involvement. This case reminds us of the role of sepsis and repeated abdominal surgery in relation to the pathogenesis of mesenteric panniculitis. We report the first case of mesenteric panniculitis mimicking Crohn's disease.

Adult↗
PubMedDate not supplied

[Kinds of home accidents].

A survey on hospitalization due to domestic accidents conducted in Padua in three public hospitals shows that between 1979 and 1988 there were 12.251 cases. Women in particular seemed to be affected by the phenomenon (7.926 cases, 64.7% of total) especially if aged 45 years or over (6.382 hospitalizations). Home injuries among females are the second cause of hospitalization due to trauma and represent the leading cause of accidental deaths (355 cases during the period of the survey). Lethality of this kind of injury progressively increases starting from the ages 30-44, and reaches 7.1% in older people (60 years or over). The causes of these accidents have been analyzed in 197 cases of fatal domestic accidents during the five years 1984 to 1988 and in 277 cases of non fatal accidents that involved subjects between the ages of 15 and 59 during the years 1986. In both situations the most frequent cause was falling (132 fatal, 159 non fatal cases); this finding shows the importance of a primary prevention programme based on the improvement of domestic structures and more care in furniture planning. The second place both among fatal and non fatal injuries belongs to burns (21 fatal and 17 non fatal). These frequently arise from incorrect behavior and emphasize in this way the necessity of improving sanitary education. A great number of home accidents (33 hospitalizations), can be attributed to bad working instruments or absence of security devices. This all shows the necessity of specific security regulations regarding installations and utensils of domestic use.

Accidental Falls↗