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Biomedical subjects

I Rowlandson

Publications and source records attributed to I Rowlandson.

7 recordsLinked to original sources
PubMed1996

Test of the acute cardiac ischemia time-insensitive predictive instrument (ACI-TIPI) for prehospital use.

STUDY OBJECTIVES: To test diagnostic performance for acute cardiac ischemia (ACI) in a manually calculated and in a computerized, ECG-calculated ACI time-insensitive predictive instrument (ACI-TIPI) in prehospital chest pain patients. METHODS: We carried out prospective inclusion and data acquisition with retrospective analysis. Over a 6-month period, 439 adult emergency medical services patients with chest pain underwent prehospital electrocardiography. Because of incomplete data, 77 cases were excluded, leaving a study sample of 362 patients. Excluded patients did not differ significantly with respect to age, sex, final diagnosis, or history of myocardial infarction, heart surgery, diabetes, or stroke. ACI-TIPI probabilities of ACI were computed on the basis of the prehospital ECGs as interpreted retrospectively and independently by two study investigators blinded to patient outcome, with a specially programmed electrocardiograph, and with a computer algorithm further modified by logistic-regression analysis. RESULTS: Diagnostic performance on the basis of receiver operating characteristic (ROC) curve areas of the ACI-TIPI was scored, by the two physician readers, .73 and .74; and by ECG, .75. Patients with low ACI-TIPI probability (0% to 9%) had no acute myocardial infarctions, a 2.3% incidence of angina, and no prehospital life-threatening events. CONCLUSION: ACI-TIPI probabilities of ACI as generated by a specially programmed electrocardiograph are comparable to those based on physician ECG interpretations and may be useful in the prehospital evaluation of chest pain.

Acute Disease↗
PubMed1992

A statistical analysis of the ECG measurements used in computerized interpretation of acute anterior myocardial infarction with applications to interpretive criteria development.

Computerized interpretation of the electrocardiogram (ECG) for detection of acute myocardial infarction (AMI) has been an area of active investigation for the past few years. Advances in the development of criteria for increased accuracy have resulted through the use of clinically correlated databases. Previously, using such databases, the sensitivity for interpretation of AMI in the Marquette 12SL ECG analysis program has increased from 21% to 65% with specificity remaining unchanged (99%). This study attempted to find measurements of the QRS and ST-segment from 7 of the 12 standard ECG leads to increase the sensitivity of detection of anterior AMI to the level of a trained physician while maintaining the current level of specificity. Regression analyses were performed on the measurements to see which ones could improve sensitivity and what effect they had on specificity. There was no clear separation of the individual measurements between the normal database or the true positive and true negative anterior AMI databases for maintaining high specificity. In a parallel study of the same data, deterministic criteria combining both ST and T wave information increased the sensitivity of the 12SL analysis program for detection of anterior AMI to 71% on a clinically correlated anterior AMI database and 75% on a physician interpreted anterior AMI database while maintaining the specificity at 99%.

Adult↗
PubMed1992

The dilemma of sensitivity versus specificity in computer-interpreted acute myocardial infarction.

The use of thrombolytic therapy and out-of-hospital electrocardiogram (ECG) acquisition capability has put even greater importance on the diagnostic accuracy of computerized ECG interpretation programs. Such programs must have extremely high specificity to minimize the possibility of clinicians treating inappropriate patients; thereby needlessly subjecting the patients to the risk of potentially life-threatening complications of the medication. At the same time, studies have shown that both prehospital personnel and emergency department (ED) physicians are aided by automated ECG interpretation programs with high sensitivity. These programs assist the attending personnel in rapidly identifying patients with suspected acute coronary thrombosis, which might otherwise have been undetected or not diagnosed until more obvious ECG abnormalities were present. In previous studies, clinically correlated databases have been used to develop and test sensitivity and specificity of the acute infarction detection algorithm in the Marquette 12SL ECG interpretation program. One program revision resulted in a marked increase in sensitivity (21-53%) without loss of specificity (99.5% to 99%). More recent studies have shown the sensitivity of the interpretation program to be influenced greatly by infarct location with sensitivity lower in anterior than inferior injury. Further refinement of the acute infarction interpretation criteria along with the methodology and data used are presented. Increased sensitivity without appreciable loss of specificity has been possible for detection of both acute inferior and anterior infarction; however, different methods were used for each location. Consideration of reciprocal or concomitant repolarization changes are found to be more useful for inferior than anterior injury. Methodological approaches are presented as they relate to the compromise between sensitivity and specificity.

Algorithms↗
PubMed1990

Computerized recognition of acute infarction. Criteria advances and test results.

The advent of thrombolytic therapy has increased the desire for an accurate computerized recognition of the ST elevation associated with acute myocardial infarction (AMI). Quantified electrocardiographic (ECG) criteria for AMI, described in the literature and in computerized ECG criteria packages, have concentrated on only those leads that exhibit ST elevation. The accuracy of this lead-specific approach has been maximized by an analysis of the associated ST-segment and T wave. Further advancement of the Marquette 12SL program's ability to classify ST elevation due to AMI has required the inclusion of those leads that are not elevated. This global approach was developed by modifying the 12SL program so that it would properly diagnose a small training set of clinically correlated AMI ECGs that did not meet the lead-specific criteria. Further training, via an evaluation of the false-positive rate, was done with a large clinical database (greater than 30,000 ECGs). Both the new and the old criteria were tested with a separate ECG database taken from a total of 296 patients. Of these, 77 had an AMI (determined via the hospital discharge diagnosis). The lead-specific criteria resulted in a sensitivity of 21% and a specificity of 99.5%. The global approach resulted in over twice the sensitivity (53%), while continuing to maintain a high rate of specificity (98%).

Algorithms↗
PubMed1986

Importance of the distance and velocity of electrical forces in the diagnosis of inferior wall healed myocardial infarction: a vectorcardiographic study.

The vectorcardiograms of 41 patients with angiographically proved inferior myocardial infarction (MI) and 51 normal subjects were analyzed to determine whether it is the time (in milliseconds) or the distance (in millivolts) of the initial superiority directed forces of ventricular depolarization that is increased more by inferior MI, and whether parameters derived from both the initial superior time and distance can be used to detect inferior MI. The 10 best individual and the 10 best paired criteria for inferior MI involve superior distance, either alone or used in the calculation of average velocity (in volts per second), and the product of initial superior time and distance (in millivolts per second). The 2 best individual criteria for inferior MI are: inferior velocity more than 0.0065 V/s (sensitivity 71%, specificity 100%) and superior distance more than 0.39 mV (sensitivity 68%, specificity 100%). These diagnostic performances are superior to those of the best criterion that involves only the duration of the initial superior forces, i.e., initial superior time longer than 28 ms (sensitivity 49%, specificity 98%) (chi 2 = 8.42, p less than 0.005 and chi 2 = 6.31, p less than 0.025, respectively). Initial superior distance and parameters calculated from both initial superior distance and time are better vectorcardiographic criteria for inferior MI than are criteria that involve only initial superior time.

Diagnosis, Differential↗