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Biomedical subjects

I Rzewnicki

Publications and source records attributed to I Rzewnicki.

At least 19 recordsLinked to original sources
PubMed2001

CD44 glycoprotein as a prognostic factor in laryngeal cancer.

An association between cell adhesion molecules expression in neoplastic tissues and cancer progression has been the focus of many recent studies. In certain tumours down-regulation of CD44 expression has been linked to the poor prognosis. The aim of the study was to evaluate CD44 expression and to determine the correlation between CD44 expression and the clinicopathological features of laryngeal cancer. The group consisted of 80 patients with primary laryngeal cancer. Tissue samples were taken from removed tumour mass during surgical treatment, CD44 expression was assessed by immunohistochemical method. The down-regulation of CD44 expression significantly correlated with a shorter disease-free survival (p<0.05). Our results suggest that CD44 expression may be useful as a prognostic marker in laryngeal cancer.

Disease-Free Survival↗
PubMed1999

Squamous cell carcinoma antigen in patients with cancer of the larynx.

The purpose of this study was to evaluate the clinical usefulness of squamous cell carcinoma antigen (SCC Ag) in patients with squamous cell carcinoma of the larynx. Plasma specimens were obtained from 70 patients with cancer of the larynx before and after treatment and during follow-up. Disease status and the marker levels were determined blind to each other. Microparticle enzyme immunoassay (IMx SCC) was used to measure the SCC Ag level. Applying standard normal limits the sensitivity of the marker at diagnosis was 25.7%. SCC Ag levels were generally lower after therapy than before. Relapse occurred more often in patients with an abnormal pretreatment SCC Ag level, which was more frequent in those with nodal invasion. The marker level increased in 70% of the patients with relapse before the clinical detection of recurrence. SCC Ag is of limited usefulness in the primary diagnosis of cancer of the larynx, but is useful in detecting recurrence of cancer.

Adult↗
PubMed1998

[Otoneurologic state estimation 2 years after tick-borne encephalitis].

In this paper an attempt is described to estimate the incidence and frequency of neurologic and otologic symptoms among patients two years after TBE. We examined 43 persons of both sexes aged 17-58. The most frequent complaints were: headache--34.9%, equilibrium problems--37.2%, buzzing in the ears--27.9%, hearing problems--23.3%, memory problems--25.6%. Decrease of throat reflexes was stated in 3 (7%) and pseudobulbaris symptoms in 2 (4.6%), weakness of muscles in 4 (9.3%). In audiometric examination decrease of hearing was stated in 8 persons (18.5%). We registered nystagmus: spontaneous--4.6-7%, gaze--13.9-18.6%, positional-T, mainly Nylen I and III type-18.6-25.6%. Pathologic recording in the eye-tracking pattern test was shown in 7 (16.3%) persons. Asymmetry of optokinetic nystagmus was stated in 6 (13.9%) examined persons. Asymmetry in caloric test was proved in 25.5% of examined persons.

Adolescent↗
PubMed1995

[Otoneurological aspects of tick-borne encephalitis].

In analysed material of 31 patients with TBE (tick borne encephalitis) we noticed symptoms evidence the impact of TBE virus vestibular system. We showed that 21 patients had disorders like dizziness and lack of balance. And 11 patients had inaudility of conductive and receiving type what was the evidence of injury of vestibular nerve. In these 11 patients we observed not normal recording of optokinetical reaction.

Adolescent↗
PubMed1995

[The examination of vestibular system in patients with degenerative changes of the cervical spine].

Degenerative changes of the cervical spine often cause the pains and vertigo as well as pathological results of otoneurological tests. The aim of the study was to estimate the frequency of the symptoms occurrence in the group of 146 patients, 63 male and 83 female, with degenerative changes of the cervical spine. Permanent or periodical headaches of various intensity occurred in 60% of the patients. Balance disturbances was observed in 74% of the patients, specially in women. In the cervical spine X-ray there were observed most frequently marginal degenerations with osteophytosis (16%), intervertebral disk narrowing (10%), and shallowing of the physiological lordosis (11%). In ENG examination, positional nystagmus (42-38%), gaze nystagmus (14-23%) were mainly recorded, with the eyes opened and closed. The eye-tracking pattern test was pathological in 57%. Optokinetic test results showed pathological records in 32% of the patients, unilateral weakness was observed in 22% and bilateral weakness in 17% of the patients. Observations mentioned above confirm frequent pathology and the necessity of early diagnosis and treatment of patients with degenerative changes of the cervical spine.

Adult↗
PubMed1995

[Original technical inventions in ENG].

Authors showed own original vestibular testing instruments. The instruments have been used in the Department of Otolaryngology of the Medical Academy in Białystok for many months.

Durable Medical Equipment↗
PubMed1990

[Causes of delayed treatment of patients with cancer of the larynx and hypopharynx in the north-eastern region of Poland].

Early diagnosis and treatment of the larynx and hypopharynx cancer is crucial in connection of the therapeutic effects and prognosis. However, our experiences pointed out that the patients came too late for treatment, sometimes several months after the beginning of symptoms. They always revealed at this moment of the first consultations more advanced local lesions and metastases in the neighbouring regions. We analysed the material of 184 patients treated in ENT Clinic of Medical Academy in Białystok according to the delayed reporting to treatment. The reasons of the delayed reporting were also evaluated. The misdiagnosis was not the main reason of the delayed treatment.

Adult↗
PubMed1989

[Evaluation of hearing in patients with diabetes].

Hearing in 60 diabetics aged 20-70 years were studied by means of tonal, verbal and B'ekèsy audiometry, SISI tests, Fowler tests, stapedius reflex and tone decay tests. The material was grouped according to the diabetes type, chronicity of disease, age, sex and presence of retino- and polyneuropathy. The results proved that diabetes may cause the progressive form of hearing loss which depend of chronicity of disease and age of patients. Sometimes the hypo-acuity may be found in the recent form of diabetes, rarely as sudden deafness. The hearing impairment is more frequent among the retino- and polyneuropathy patients. The localisation of lesions may be in all part of hearing pathways from the labyrinth to cortical areas.

Adult↗