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Biomedical subjects

I S Chekman

Publications and source records attributed to I S Chekman.

At least 19 recordsLinked to original sources
PubMed1999

[The clinico-pharmacological activity of Agapurin].

Data from published literature are generalized together with results of the authors' studies on clinical pharmacology of the metabolite drug agapurin (pentoxifulline). It is shown to be of high therapeutic efficacy in postinsult syndrome, varicose ulcers, gangrene, frostbite, paresthesias, acrocyanosis, Raynaud's disease, cerebral circulatory ischemic disorders, postischemic/hemorrhagic insult states, circulation disorders in the vessels of the eye, of the internal ear, in male sterility.

Contraindications↗
PubMed1993

[Folk medicine agents in the treatment of patients with hemorrhoids].

Folk method on hemorrhoid treatment are outlined. The author emphasizes prevention of exacerbations, inflammation of the hemorrhoidal nodes in rectal tissues by local and general treatment methods including exercise therapy, active way of life. Hypodynamia, sessile way of life may result in exacerbation of hemorrhoids. The author recommends various folk medicine agents, describes their composition, doses.

Baths↗
PubMed1992

[Ultrastructure of donor blood lymphocytes incubated with Amanita phalloides poison].

Heparinized donor blood was investigated incubated with Amanita Phalloides poison in the dose of 0.05 and 0.5 LD100 during 1 and 3 hours. Lymphocyte structure changes showed cytoplasma and organoid membrane destabilization, cytoplasma degranulation, appearance of autolysis foci and lysed cells. This destruction became particularly marked with increasing poison dose and infusion time.

Amanita↗
PubMed1991

Computer analysis of drug therapy in cardiac patients. Preliminary communication.

The authors present a system of computer control in drug therapy of cardiac patients aimed at preventing complications and adverse interactions of simultaneously administered drugs. The system includes data on the 196 most frequently used cardiac drugs and 433 other drugs showing clinically important interactions with cardiac drugs.

Algorithms↗
PubMed1986

[Electrophysiological research on the coupling of excitation-contraction during alpha-adrenoreceptor activation in blood vessel smooth muscles].

Alpha 1-adrenoceptor blocker--prazosin--was found to inhibit noradrenaline-induced depolarization and concentration in the smooth muscles of the portal rabbit vein, indicating that this reaction was due to alpha 1-adrenoceptor activation. In the pulmonary artery both alpha 1 and alpha 2-adrenoceptors appear to be involved in noradrenaline excitatory action, as the effect was not completely inhibited by prazosin. The results suggest that hypotensive action of prazosin is related to the cessation of Ca2+ ion influx through alpha 1-operated calcium channels. The decrease in Ca2+ influx through voltage-dependent calcium channels due to prazosin-evoked elimination of depolarization can also contribute to this effect.

Action Potentials↗
PubMed1985

[Interaction of beta-adrenergic agents with the plasma membranes of the myocardium].

The initial stage of interaction of beta-adrenomimetics and beta-adrenoblockers with specific membrane binding sites is characterized by different patterns of thermodynamic parameters. Administration of isadrin results in a decrease of entropy and enthalpy, which reflects the primary binding reaction and agonist-specific receptor isomerization to the conformational form activating adenylate cyclase. Anaprilin and alpheprol do not change the receptor conformation and participate only in the primary binding reaction which is marked by a decrease in enthalpy and a rise of entropy in the course of interaction of beta-adrenoblockers with specific membrane binding sites. The different patterns of thermodynamic parameters under the effect of beta-adrenomimetics and beta-adrenoblockers on plasma membranes are explained by the different influence of these substances on the mobility of membrane lipids, i.e. on the viscosity of plasma membranes.

Adrenergic beta-Antagonists↗