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Biomedical subjects

I S Chekman

Publications and source records attributed to I S Chekman.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[Combination phytotherapy in the treatment of heart failure].

In the article, data from the published literature are summarized together with results of the author's investigations relevant to aspects of pharmacotherapeutical efficacy of cardiac glycosides, plants endowed with antihypertensive and diuretic activities in acute and chronic heart failure. Pharmacological mechanisms of action of a new combined vegetal drug, chomvikorin-N, are described in detail; its clinical efficacy is shown in the treatment of heart failure.

Acute Disease↗
PubMedDate not supplied

[Clinico-pharmacologic activity of organic nitrates].

A summary of the published literature is presented together with findings from the author's investigations designed to study clinical-and-pharmacological properties of organic nitrates. The history is written up of discovery of a therapeutic effect of organic nitrates, pharmacokinetics, pharmacodynamics are described, indications for administration thereof are determined, ill effects of glycerol trinitrate (nitroglycerin), isosorbide dinitrate (nitrosorbide) and isosorbide-5-mononitrate (olicard) are described.

Humans↗
PubMedDate not supplied

[Characteristics of the reaction of the renal tissue adenylic system to the beta-adrenoblockader, trasicor (oxprenolol), in early postnatal ontogeny].

Trasicor (oxprenolol) was introduced intraperitoneally to mongrel albino rats of 4 age groups (7, 14, 30 days old and adults) in single effective and resistance doses, following which the ATP, ADP, AMP and NP content in the renal tissue homogenates was determined. At early stages of postnatal ontogenesis the animals are shown to be less sensitive to the drug than in the case of adult rats. Possible increases in the dosage of trasicor in the pediatric practice are deemed permissible.

Adenine Nucleotides↗
PubMedDate not supplied

[Effect of phentolamine and anaprilin on the makeup and distribution of electrolytes in the myocardium].

Acute tests with rats demonstrated that the adrenoblocking agent phentolamine acts predominantly on the potassium level in the myocardium, raising its total, intra- and extra-cellular content. The effect of anapriline was mainly on sodium. Thyramine, which like adrenoblocking agents displays a catecholine-reducing effect, did not produce any similar changes in the potassium and sodium content.

Animals↗
PubMedDate not supplied

[The effect of sodium salicylate and phenobarbital on the anti-arrhythmia properties of novocainamide and acetylnovocainamide].

CaCl2 and aconitic models of arrhythmias were reproduced in experiments with rats. Sodium salicylate was found to decrease the preventive effect of ecetylnovocainamidum and increased the effect of novocainamidum on ECG changes. Sodium salicylate diminished the preventive effect of acetyl-novocainamidum by elevating myocardial Na+ concentrations, favoured the decrease in myocardial K+ levels, eliminated the preventive effects of novocainamide and acetylnovocainamide by altering myocardial energy metabolism in CaCl2-induced arrhythmia and improved the preventive effect of acetyl-novocainamide on these parameters in aconitic arrhythmia.

Acecainide↗
PubMedDate not supplied

[Effect of compounds having hypotensive activity on microviscosity of phospholipids membranes].

Vincapane, apressin, raunatin, reserpine and prazosin have been studied for their effect on the state of microviscosity of phospholipid bilayers from lecithin and cardiolipine. The method of fluorescent probing using pyrene and asymmetrical polymethine dye 4501 u have been used for this study. Character of changes of phospholipid bilayers microviscosity as affected by these compounds depends on their concentration in the solution. Vincapan lowers microviscosity of membranes from lecithin in the interval of the concentrations given. Advantages of fluorescent probing by means of asymmetric polymethine dye in comparison with pyrene were shown.

Antihypertensive Agents↗
PubMedDate not supplied

[Clinical pharmacology of hepatoprotectors].

Data from published literature are summarized together with findings secured in the author's investigations on clinical pharmacology of hepatoprotectors. Classification of hepatoprotectors is submitted, their effects on the functional condition and metabolism in hepatocytes are discussed. Details are given of clinical and pharmacological properties of hepabene, legalon, essentiale, sirepara, wobenzime, phebichol, antral, thiotriazone.

Animals↗