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I S Forrest

Publications and source records attributed to I S Forrest.

11 recordsLinked to original sources
PubMed1976

The passage of 14C-delta-9-tetrahydrocannabinol into the milk of lactating squirrel monkeys.

Lactating squirrel monkeys chronically receiving 2 mg/kg delta-9-tetrahydrocannabinol (THC) orally either two or five times weekly were given a tracer dose of 14C-delta-9-THC mixed with the delta-9-THC. This permitted radioquantitation of the THC in milk specimens collected 1 to 24 hr after administration of the labeled dose. Correlated specimens of urine and feces were also collected individually from mothers and infants and were subjected to radioquantitation and exploratory TLC. During the 24-hr observation period, approximately 0.2% of the labeled delta-9-THC appeared in the milk, whereas 42% and 1% were excreted in the feces and urine, respectively. Infants that suckled during the 6 hr immediately after their mothers were administered the labeled compound excreted an average of 0.01% and 0.12% of the mother's dose in the urine and feces, respectively, during the 18 hr after suckling.

Animals↗
PubMed1975

Chlorpromazine excretion in chronically dosed primates. I. Occurrence of a previously unreported class of chlorpromazine conjugates.

The use of tritiated chlorpromazine to correlate total excretion of radioactivity with characterization of the radioactive metabolites had shown a substantial discrepancy. While radioactivity was totally excreted and accounted for within three weeks, recognizable chlorpromazine metabolites represented only about two thirds of the radioactivity in any given sample. To rule out tritium exchange, 14C-labeled chlorpromazine was administered to Rhesus monkeys. The same discrepancy was observed, primarily in the conjugated drug fraction. Therefore, all unconjugated chlorpromazine metabolites were exhaustively extracted, and an alkaline hydrolysis performed. The aglycones liberated thereby were again carefully removed, and the residual aqueous fraction was subjected to an acid hydrolysis. This procedure yielded an additional group of known and unknown phenolic chlorpromazine aglycones, representing approximately one third of the radioactivity in the whole urine. Preliminary trials on urine pools of patients chronically dosed with chlorpromazine yielded essentially the same results. The structure of this new class of chlorpromazine conjugates has not yet been elucidated, nor is the ligand known at this time. A glucoside-type bond may characterize this significant class of chlorpromazine.

Animals↗