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Biomedical subjects

I S Thomsen

Publications and source records attributed to I S Thomsen.

7 recordsLinked to original sources
PubMed1984

Analysis of syndromes using Bayes's formula.

A method of demonstrating syndromes by means of Bayes's formula with correction for redundancy is described. By analysing a database from 421 patients, it was possible to produce the well-known syndromes and alternative patterns forming the basis for a diagnosis, choice of treatment and estimation of its results. In this way an inferential classification is prepared while other and similar methods mainly make use of a denominational classification. Advantages and disadvantages of both procedures are discussed.

Adjustment Disorders↗
PubMed1981

Analysis of information in indicant-patterns.

Different patterns of information may lead to identical diagnostic conclusions, but it remains uncertain whether such patterns will have the same validity towards other criteria, e.g. choice of treatment. A procedure for selection of optimal patterns of data and analysis of their validity towards different criteria is described. It is founded on Bayes' methodology and characterized by a continuous correction for redundancy between indicants. Permissible patterns/syndromes are formulated and evaluated in a consistent way.

Diagnosis, Computer-Assisted↗
PubMed1981

Evaluation of data-base.

The records of 421 psychiatric patients were analysed by a consistent method, allowing an optimal use of indicant-patterns. It was assumed that such a procedure would give a satisfactory predictive capacity, even for operational criteria as for example choice of treatment, duration of stay in hospital, or a global evaluation of outcome. The study demonstrates, however, that fundamental changes in the data-base are necessary. Problems of reliability, validity, sensitivity and specificity are discussed and some suggestions are offered for the future improvement of psychiatric data-bases.

Diagnosis, Computer-Assisted↗
PubMed1980

Plasma levels of zimelidine and norzimelidine in endogenous depression.

A new serotonin uptake inhibitor zimelidine was studied in 16 endogenously depressed inpatients, who received 150 mg/kg orally during 3--6 weeks in a phase II-type study. Plasma concentrations of zimelidine and its main metabolite norzimelidine were determined twice a week. Ten patients obtained a well-defined steady-state plasma level within 1--2 weeks, while three patients still had increasing concentrations of both substances or only norzimelidine within the investigation period. In two patients, biochemical affection of the liver could be demonstrated during the treatment; one associated with moderate clinical symptoms (dizziness and fever), the other without clinical symptoms. Both patients recovered upon cessation of the zimelidine treatment. In the former patient, very high concentrations of zimelidine at the time of hepatic symptoms were demonstrated, while the latter patient was within the average concentration range. Other adverse reactions were mild and few, particularly with respect to anticholinergic effects. With the applied, probably suboptimal, dosage the therapeutic response was only satisfactory in five cases.

Adult↗