Biomedical subjects

I Sandefo

Publications and source records attributed to I Sandefo.

3 recordsLinked to original sources

PubMed2004

[Labour epidural analgesia in Martinique: evaluation of quality and accessibility to epidural analgesia by the patients in level one obstetric clinic].

OBJECTIVES: The main aim of this study was to evaluate real-life experience and the quality of labor epidural analgesia (LEA) by the patients, from the anaesthesia consultation to leaving the clinic after childbirth. STUDY DESIGN: Descriptive study. PATIENTS AND METHODS: This study took place over a period of 8 weeks, at the level I obstetric clinic in Martinique. One hundred and thirty-four successive patients completed an anonymous questionnaire following childbirth. RESULTS: During the study period (134 patients completed the questionnaire, corresponding to 100% return) 127 women had asked for LEA (94%), which was possible in 94%, with a patient satisfaction level of 94% and an average mark for quality at 18/20. The quality of information given at the anaesthesia consultation was judged excellent for 97%, and 91% were reassured by the consultation. The delay between the demand and the LEA procedure was less than 15 min in 63%, and in 39% the procedure was done during the night. The procedure was painless in 63%, and 97% of women were ready to begin the same procedure again. CONCLUSION: This study seems to underline the fact that the needs and the acceptability of LEA are the same in Martinique as in mainland France. This study does not support the hypothesis of the cultural barrier to justify the low level of LEA in the Overseas Departments. An obvious result seems to be that good organization of anaesthesia and obstetric services results in a natural increase in LEA demand.

Adult↗

PubMed2004

Ketamine does not decrease postoperative pain after remifentanil-based anaesthesia for tonsillectomy in adults.

BACKGROUND: There are conflicting results concerning the pre-emptive effect of ketamine on central sensitization following surgery. The aim of this prospective, randomized, double-blind, placebo-controlled study was to assess the effect of the N-methyl-D-aspartate receptor antagonist ketamine on postoperative morphine consumption and pain score after remifentanil-based anaesthesia in adult patients scheduled for tonsillectomy. METHODS: We studied 40 adult patients undergoing elective tonsillectomy. Total intravenous anaesthesia was induced and maintained with remifentanil (0.125-1.0 microg kg(-1) min(-1)) and propofol target-controlled infusion. Patients in group K received a bolus dose of ketamine 0.5 mg kg(-1) immediately after anaesthetic induction, followed by a continuous infusion of 2 microg kg(-1) min(-1). Saline was administered in the same sequence in group S. Propofol, remifentanil, and the study drug infusions were discontinued at the end of surgery. RESULTS: Intraoperative remifentanil consumption (0.57 +/- 0.18 in group K vs. 0.55 +/- 0.14 microg kg(-1) min(-1) in group S), morphine requirement in the PACU (11 +/- 3 in group K vs. 9 +/- 4 mg in group S) and in the ward (22 +/- 11 in group K vs. 25 +/- 14 mg in group S), median time to first analgesia in the ward (338 +/- 126 in group K vs. 328 +/- 144 min in group S), and VAS pain scores were comparable in both groups. CONCLUSION: Small-dose of ketamine does not seem to be a useful adjunct to remifentanil-based anaesthesia during short, painful surgical procedures.

Adult↗

PubMed2000

Evaluation of donor cardiac function for heart transplantation: experience of a French academic hospital.

OBJECTIVES: The diagnostic and therapeutic approaches for evaluation and management of cardiac function in brain-dead patients vary from country to country. The aim of the present study was to describe the results of the evaluation of brain-dead patients as potential cardiac donors in a French teaching hospital that manages the largest number of brain-dead patients in France. METHODS: Demographic parameters, the causes of brain death, clinical evolution, hemodynamic parameters, doses of inotropic and/or vasopressive drugs, the results of echocardiographic examination, and several biochemical markers of myocardial cell injury were retrospectively collected. RESULTS: Seventy-one consecutive brain-dead patients admitted to the intensive care unit of the Academic Hospital of Nancy from October 1st, 1998 to September 30, 1999 were analyzed. Twenty-nine patients were considered as potential heart donors: 22 males and 7 females aged 33 +/- 3 years (Mean + SEM). The cause of brain death was head trauma in 17 cases (59%), cerebrovascular disease in 10 cases (34%), and cerebral anoxia related to cardiac arrest in 2 cases (7%). Eighteen hearts (18/29 or 66%) were harvested and transplanted with a favorable outcome at one month in 17 cases. In 11 cases, the heart was not harvested, nine (9/29 or 31%) because of myocardial dysfunction upon subsequent echocardiographic examination and 2 because of the lack of matched recipients. CONCLUSION: Comparison of these results with those of other groups suggests that hormonal substitution with insulin and triiodothyronine in the presence of myocardial dysfunction could be of potential interest to correct myocardial dysfunction and increase the number of donor hearts.

Academic Medical Centers↗