PubMed Health⌕ Search

Biomedical subjects

I Sandström

Publications and source records attributed to I Sandström.

8 recordsLinked to original sources
PubMed1988

Neonatal chlamydial conjunctivitis. A long term follow-up study.

Chlamydia trachomatis (Ct) was isolated from eyes of 33 out of 160 infants with neonatal conjunctivitis. In nineteen (58%) of the infants with chlamydial conjunctivitis Ct could also be isolated from the nasopharynx. All infants were treated with oral erythromycin ethylsuccinate 25 mg/kg every 12 hours for 14 days combined with lid hygiene. All were clinically cured, and none had a relapse of clinical Ct conjunctivitis during an observation period of one year. However, one infant had persistent asymptomatic chlamydial eye infection, two displayed a persistent infection of the nasopharynx, and one infant's vagina was infected despite therapy. Serum IgG antibodies to Ct were significantly more often detected in clinical cases (90%) than in controls (33%) (p less than 0.01). Infants with conjunctivitis developed detectable IgM antibodies to Ct in 43% as compared to 7% in controls (p less than 0.01).

Conjunctivitis, Inclusion↗
PubMed1988

Levels of erythromycin in tear fluid and serum in infants with conjunctivitis.

38 newborns with purulent conjunctivitis were treated with oral erythromycin ethylsuccinate 25 mg/kg every 12 h for 14 days. 3-4 days after initiation of therapy, erythromycin levels in serum and tear fluid were measured 1 and 12 h after the administration of erythromycin. The level of erythromycin in tear fluid was significantly higher than that in serum 1 and 12 h after administration of the antibiotic. On both occasions the concentrations of erythromycin in tear fluid and in serum exceeded the minimum inhibitory concentration (MIC) in vitro for Chlamydia trachomatis.

Chlamydia trachomatis↗
PubMed1987

Treatment of neonatal conjunctivitis.

The effect of different treatment regimens on clinical and microbiologic cures of neonatal conjunctivitis was evaluated during a 32-day observation period. In 84 infants with mild to moderate conjunctivitis and no signs of dacryocystitis, clinical cures were achieved in more than 50% of the cases with lid hygiene only. Staphylococcus aureus was the most common organism (48%) isolated from these infants. Chlamydia trachomatis could not be isolated from eyes with mild to moderate conjunctivitis. Forty-four infants with severe conjunctivitis, with or without dacryocystitis, were randomly assigned to treatment with either topical chloramphenicol or oral erythromycin for 14 days. Chlamydia trachomatis was isolated from 19 (43%) of these infants. All infants with chlamydial conjunctivitis who were treated with 25 mg/kg of oral erythromycin ethylsuccinate twice daily for 14 days were clinically and microbiologically cured. In contrast, all treatment of chlamydial conjunctivitis with topical chloramphenicol failed clinically as well as microbiologically. Dacryocystitis was a common complication in neonatal conjunctivitis (17%). The clinical failures in neonatal nonchlamydial conjunctivitis were associated with persistent obstruction of the nasolacrimal duct.

Administration, Oral↗
PubMed1987

Etiology and diagnosis of neonatal conjunctivitis.

Chlamydia trachomatis was isolated from the most inflamed eye of 13 of 107 (12%) infants with neonatal purulent conjunctivitis and from none of 100 healthy infants (p less than 0.01). Staphylococcus aureus was recovered from 49 (46%) inflamed eyes and from 8 (8%) healthy eyes (p less than 0.01). Streptococcus pneumoniae, Haemophilus influenzae, Branhamella catarrhalis, Escherichia coli and Klebsiella pneumoniae were isolated from very few infants with conjunctivitis but not from controls. No organisms could be recovered from 23 (22%) infants with conjunctivitis and from 60 (60%) healthy infants (p less than 0.01). The incidence of neonatal purulent conjunctivitis was 107 (2%), of 5,924 births. Eyes infected with C. trachomatis were significantly more inflamed than eyes from which S. aureus or no organisms could be isolated. Furthermore, conjunctival "pseudomembranes" were associated with C. trachomatis. The age at onset of the chlamydial conjunctivitis was higher compared to the age at onset of conjunctivitis in which S. aureus or no organisms were isolated.

Bacteriological Techniques↗
PubMed1984

Neonatal conjunctivitis caused by Chlamydia trachomatis.

Chlamydia trachomatis is a common cause of neonatal infection in industrialized countries and is acquired from the infected maternal cervix. Multiple mucosal surfaces, including the respiratory and the gastrointestinal tract as well as the conjunctiva, will be colonized by the organism. Conjunctivitis and pneumonia are the illnesses presently recognized as manifestations of these infections. C. trachomatis is isolated from the eye in 14 to 25% of patients with neonatal conjunctivitis and there is often an associated nasopharyngeal infection. The conjunctivitis is often the first clinical manifestation of these potentially systemic infections and therefore systemic therapy is required. The recommended treatment in neonatal chlamydial conjunctivitis is oral erythromycin 25 mg/kg every 12 hours for 14 days. This dose is well tolerated by the infant. Parents of infants with chlamydia infection should be treated with oral erythromycin or tetracyclines. Erythromycin should be given to breast feeding mothers.

Bacteriological Techniques↗