PubMed Health⌕ Search

Biomedical subjects

I Satoh

Publications and source records attributed to I Satoh.

At least 19 recordsLinked to original sources
PubMed1990

[Informed consent of the family in the chemotherapy for lung cancer].

In Japan where the question of cancer notification has yet to be resolved, it is difficult to obtain an informed consent from the patient himself in clinical studies of the chemotherapies for cancer. In fact, the chemotherapy is administered while not enough explanation is given to the family let alone the patient. Such is the present situation. For the purpose of finding out the best possible method at present, we carried out a method whereby an informed consent of the family is substituted for a consent of the patient in phase II study of inoperable non-small cell carcinoma of the lung. As a result, the consent was obtained from 21 (91.3%) out of 23 families. This method should be taken into consideration as a feasible one under the present circumstances. It was in only one family (4.3%) that a consent on the notification of diagnosis from the family to the patient was obtained. In order for the informed consent to be established, efforts to form a social consensus on cancer notification are needed.

Adult↗
PubMed1990

Growth dynamics of the heart from perinatal period to childhood.

In order to obtain information useful for the diagnosis of fetus and newborn heart disease, we established a theoretical model of perinatal cardiac growth. We measured with the use of ultrasonic cross-section imaging system the mitral valve ring dimension, tricuspid valve ring dimension, and total cardiac dimension as morphological parameters of the heart in 45 cases composed of fetuses and children. The obtained data were entered into a computer. With the use of these data, simulation was made on the basis of the general theory of biological development. The present simulation showed that from the fetal stage to childhood the growth rates of the foregoing three morphological parameters mutually differ, but during the period of growth to the age of 12 years of the present study, they all demonstrated continuous growth up to 3 1/2 years after birth when they reached a growth saturation level.

Aging↗
PubMed1990

[Root resorption of vital and endodontically treated teeth in orthodontic movement].

Orthodontic tooth movement frequently induces the resorption of the tooth root, although valuable information concerning the relationship between the root resorption and force magnitude, duration and types of tooth movement and the condition of periodontium obtained. However, it is incompletely known that the situation of candidated tooth itself of orthodontic movement in which pulpectomized non-vital condition influence the process of root resorption and subsequent repairing. Thus, the study was conducted to clarify the effect by the pulpectomy accompanied with tooth movement on the process of root resorption and regeneration of periodontium. A hundred and fifty Wistar rats, weight 180-200 g, 6 weeks old, were used as experimental animals. Prior to experimental tooth movement, first molars of 50 rats were received pulpectomy on both sides followed by filling of root canal (first group) and those of another 50 rats on single side (second group). Maxillary first molars of the other 50 rats were saved as a vital dental pulp control (third group). The first and the third groups of animals were then subjected to experimental tooth movement with the interproximal insertion of elastic rubber as described by Waldo (1953) for 3 days, 1, 2, 3 and 4 weeks. After tooth movement was terminated, animals were sacrificed by ether inhalation or by perfusion of glutaraldehyde fixation solution. The upper jaw from each rat was dissected and prepared specimens for non-decalcified section and light microscopic section. Root resorption and regeneration of cementum were evaluated quantitatively using the modular system for semiautomatic quantitative evaluation of images on the light microscopic section. Occurrence of external root resorption with multinucleated odontoclast associated with experimental tooth movement in pulpectomized tooth were lesser and later than those of vital teeth. These findings suggest that the dental pulp plays an important role in the processes of root resorption and remodeling of cementum associated with orthodontic tooth movement.

Animals↗
PubMed1978

Evoked electromyographic test applied for recurrent laryngeal nerve paralysis.

This study was performed to apply the evoked electromyographic (EMG) test to the larynx and to find out whether or not this test is useful for diagnosis of patients with recurrent laryngeal nerve paralysis. As a result, it was considered that the present test was useful for the following: 1. Diagnosis of the site of lesion: The decision is easily made whether the recurrent laryngeal nerve is damaged alone or together with the superior laryngeal nerve, and on the site of damages along the recurrent laryngeal nerve in some cases. 2. Determination of prognosis: The cases showing no evoked wave may not recover completely. For the cases showing an evoked wave, information on prognosis can be obtained from the degree of changes in latency and evoked wave form. 3. Indication of the state of nerve regeneration: The evoked EMG test is able to reveal the state of reinnervation of the paralyzed laryngeal nerve as well as and even earlier than the ordinary EMG test.

Adult↗
PubMed1977

A demand diaphragm pacemaker.

A PACO2 feedback control system (demand diaphragm pacemaker) was developed in this laboratory to maintain homeostasis during diaphragm pacing, thus avoiding hypo- or hyperventilation. Application of this system to the research animal made it possible to maintain blood gases and pH within normal limits for up to 15 hrs. Oscillation between maximal tidal volume and apnea that occurred with the amplitude feedback control was eliminated by using a rate feedback control. A possible additional benefit of a feedback control system is the reduction of current applied to the nerve as compared to that in asynchronous pacing, thereby minimizing the fatigue phenomenon.

Animals↗
PubMed1976

Patulous Eustachian tube. A new treatment with infusion of absorbable gelatin sponge solution.

For the treatment of abnormally patent Eustachian tube, we had previously employed repeated tubal insufflation of salicylic acid-boric powder (1:4) through a Eustachian tube catheter. Such treatments, however, usually were associated with uncertain results and numerous complications. Therefore, treatment of this condition was changed to employment of an infusion of absorbable gelatin sponge solution directly into the Eustachian tube. Twenty-two ears in 16 patients recovered successfully when this method was used.

Adult↗