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Biomedical subjects

I Saxén

Publications and source records attributed to I Saxén.

12 recordsLinked to original sources
PubMed1975

Associations between oral clefts and drugs taken during pregnancy.

Associations between drug consumption during pregnancy and the birth of children with oral clefts were studied in material from the Finnish Register of Congenital Malformations, consisting of 599 children with clefts and their matched controls. Information concerning maternal drug consumption was partly prospective. During the first trimester, analgesic, chemotherapeutic and antineurotic drugs had all been significantly more frequently used by the mothers of children with clefts, than by the control mothers. The consumption of drugs was in general more frequent among mothers of children with cleft lip, with or without cleft palate, than among those of children with cleft palate alone.

Abnormalities, Drug-Induced↗
PubMed1975

The association between maternal influenza, drug consumption and oral clefts.

The linkage between potentially teratogenic factors was studied in a material of 599 children with oral clefts and their matched controls. A method based on Yule's Q coefficient describing the degree of association between two dichotomous variables was applied. All factors studied (five groups of drugs taken by the mothers during early pregnancy, maternal influenza and fever) were significantly associated with the birth of children with clefts. The only factor whose association with clefts was explained by linkage to other factors was fever. In addition, the association between clefts and antipyretic analgesics other than salicylates could be partly explained by controlling the intake of salicylates. Although there was a strong association between influenza and consumption of salicylates, the correlation of neither of the two factors with oral clefts could be even partly explained by controlling the other. The method is considered suitable for epidemiological studies of congenital defects.

Abnormalities, Drug-Induced↗
PubMed1975

Prolonged in vitro closure of the mouse secondary palate by salicylates.

In organ culture sodium salicylate and acetylsalicylic acid in a 1.4 mM concentration caused prolongation of the time needed for the closure of the mouse secondary palate. The response of Strain A and the hybrids CBA X A was more distinct than that of Strain CBA. The mitotic rate, calculated from serial sections, was significantly reduced in the salicylate-treated shelves in both strains. The extrapolation of the results to an in vivo situation is discussed in the light of different theories of the mechanism of cleft palate formation.

Animals↗
PubMed1975

Epidemiology of cleft lip and palate. An attempt to rule out chance correlations.

The findings of a previous epidemiological study on oral clefts (599 children) were tested in an independent sample of 194 children, using the same source as for the previous study (Finnish Register of Congenital Malformations). Several of the earlier results--such as seasonal variation and associations between clefts and parental age, social factors, and emotional stress--were not reproduced. It is concluded that chance correlations introduce a marked problem to epidemiological studies. The findings of both studies show that there is an exceptionally high incidence of cleft palate in Finland. Significant geographical variations and associations between clefts and prematurity, threatened abortion during the first and second trimesters, maternal drug consumption during the first trimester, and influenza and fever during the first trimester were found. The possible role of these findings in the aetiology of oral clefts is discussed, and particular attention is paid to the possible teratogenicity of salicylates.

Abnormalities, Drug-Induced↗