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Biomedical subjects

I Schütz

Publications and source records attributed to I Schütz.

At least 19 recordsLinked to original sources
PubMed2006

Profilin and Rop GTPases are localized at infection sites of plant cells.

We have found 5 profilin cDNAs in cultured parsley cells, representing a small gene family of about 5 members in parsley. Specific antibodies were produced using heterologously expressed parsley profilin as antigen. Western blot analysis revealed the occurrence of similar amounts of profilin in roots and green parts of parsley plants. Immunocytochemical staining of parsley cells infected with the oomycetous plant pathogen Phytophthora infestans clearly revealed that profilin accumulates at the site on the plasma membrane subtending the oomycetous appressorium, where the actin cables focus. We also observed the accumulation of Rop GTPases around this site, which might point to a potential function in signaling to the cytoskeleton.

Actins↗
PubMed2001

Evidence for type II phytochrome-induced rapid signalling leading to cab::luciferase gene expression in tobacco cotyledons.

We studied the activation of cab gene expression by phytochrome-induced intercellular signalling and report insights into the mechanism of induction and outspread of a plant internal signal. By micro-beam irradiation techniques and use of a photon-imaging charge-coupled device (CCD) camera system we monitored cab::luciferase reporter gene expression in cotyledons of transgenic tobacco (Nicotiana tabacum L. cv. Xanthi) plants. We found that (i) the photoreceptor triggering intercellular signalling and reporter-gene expression is type II but not type I phytochrome, (ii) phytochrome in its far-red-absorbing (Pfr) form is necessary for the induction but not for the outspread of the signalling, (iii) red/far-red reversibility is restricted to the red-irradiated cells, and (iv) the phytochrome-induced signal spreads rapidly throughout the cotyledon and reaches its target cells within minutes.

Arabidopsis Proteins↗
PubMed1991

[Bilateral chylothorax--case report and literature review].

A bilateral chylothorax developed in a woman patient during recurrence of a non-Hodgkin's lymphoma, originally treated by laminectomy and telecobalt irradiation. Almost simultaneously there was a thrombosis of the brachial vein in the right arm. On the basis of this particular case, attention is drawn to the difficulty in pathogenetic classification. The possible causes, especially of the bilateral nature of the chylothorax, are discussed while referring to the relevant literature.

Abdominal Neoplasms↗
PubMed1987

[Postoperative disorders of cardiovascular function].

Cardiovascular instability is the cause of almost 50% of postoperative complications and raises postoperative mortality far above that intraoperatively. The aged patient with pre-existing heart disease represents a high postoperative risk. These patients are very susceptible to hypoxia, anemia, hypovolemia, the negative inotropic effects of certain anesthetics, and increased oxygen consumption due to shivering. The reversal of anesthetic agents is also rather debatable in these cases. Hypertension and arrhythmias are common phenomena in the recovery room. They may be aggravated by a number of factors such as metabolic and respiratory imbalances, incorrect fluid substitution, pain, or excitation. The frequency of postoperative myocardial infarction (MI) depends upon pre-existing coronary artery disease and hypertension. A medical history of heart failure or previous MI also plays an important role hemodynamic course as do the surgical procedure and the intraoperative. Postoperative hemodynamic monitoring should be performed according to the standards suggested by the American Society of Anesthesiologists. Medical treatment basically consists of symptomatic therapy and the avoidance of risk factors. Specific treatment is rarely required.

Cardiovascular Diseases↗
PubMed1985

Heterozygosity in the Pi-system as a pathogenetic cofactor in chronic obstructive pulmonary disease (COPD).

A population (n = 526), consisting of employees with COPD, was compared with 2 control populations for the prevalence of Pi-phenotypes. In the patient group, the proportions of ZZ, SZ and MZ were significantly elevated. Among the patient population a prospective study was carried out to evaluate the role of alpha 1-antitrypsin deficiency as a cofactor in COPD. Severity of disease was estimated by standard pulmonary function tests, X-ray signs for emphysema and clinical assessment. Patients with ZZ, SZ and MZ were significantly worse than their MM partners. An influence of MS cannot be rejected. Phenotyping of all patients with COPD is advocated. Screening can also be by determining the ratio of alpha 1-antitrypsin and acid alpha 1-glycoprotein concentrations, which allowed detection of all ZZ, SZ, MZ and about 60% of the MS patients.

Adult↗
PubMed1981

[New pathogenetic aspects of rheumatoid arthritis].

Inflammatory changes in the epiphyseal bones in patients with rheumatoid arthritis are demonstrated which correspond to changes in the bone organ far from pannus. They may be the cause for the demineralisation near to joint (first x-ray sign to rheumatoid arthritis). Further from the analysis of immune complexes of patients with rheumatoid arthritis apart from rheumatoid and antinuclear factors and IgM-antibody against plasma membranes was the result. These two findings are new in the description of the pathogenesis of rheumatoid arthritis. Their possible importance for the development of the arthrosis is discussed.

Antibodies, Anti-Idiotypic↗