PubMed Health⌕ Search

Biomedical subjects

I Shaw

Publications and source records attributed to I Shaw.

33 records · Page 2Linked to original sources
PubMed1993

Demography, nursing and community care: a review of the evidence.

Demography is a most powerful influence upon social policy making. Policy making cannot be divorced from the constitution and the characteristics of the population for which it is intended. This paper commences by identifying and reviewing the most potent of those trends, and then examines the implications, first for the capacity of the community to cope with its dependents and then for the supply of nurses, before illustrating the importance of community nursing to government policies on community care.

Adult↗
PubMed1993

You in Mind: a preventive mental health television series.

This study of BBC Television's 'You in Mind' series provides preliminary evidence for the benefits of a mass media approach to preventive mental health. The series was seen by a large national audience who appraised it positively. It had a greater impact in the area of understanding problems as opposed to seeing what to do about them, and a greater impact on the viewer's perceptions of the problems of people the viewers knew, as opposed to the problems of the viewers themselves. Measures of intentions to change behaviour, even when corrected for over-reporting, suggest that a significant minority of the audience had changed or intended to change their behaviour as a result of the series. However, no specific pre-post changes in coping or help-seeking were found. These findings are discussed in terms of the potential and limitations of the mass media for mental health promotion.

Adolescent↗
PubMed1992

Receptor-based assays in screening for biologically active substances.

Molecular biology has identified new receptors and ligands which are deregulated in diseases such as cancer and autoimmune conditions and which provide rational targets for therapeutic intervention. Advances in instrumentation and methodology make it possible to screen large numbers of samples in simple receptor-ligand binding assays in the search for drug candidates. Caution must be exercised in the interpretation of data derived from such assays. This is particularly pertinent to the recently characterized receptors, such as the cytokine receptors, as we do not fully understand the relationship between the receptor type and the linkage of receptors to the appropriate or inappropriate second messenger systems that are used in the experimental screening protocols and the disease state.

Humans↗
PubMed1990

Cellular isoform of the scrapie agent protein participates in lymphocyte activation.

The scrapie agent protein (Sp33-37 or PrPSc) is the disease-associated isoform of a normal cellular membrane protein (Cp33-37 or PrPC) of unknown function. We report that normal human lymphocytes and lymphoid cell lines, but not erythrocytes or granulocytes, express PrPC mRNA and protein. PrPC is detectable on the surface of lymphocytes; the surface immunoreactivity is sensitive to phosphatidylinositol-specific phospholipase C, indicating glycosyl-phosphatidylinositol membrane anchorage. Lymphocyte PrPC surface abundance is increased by cell activation, and polyclonal antibodies to PrPC suppress mitogen-induced activation. We conclude that PrPC is a lymphocyte surface molecule that may participate in cell activation.

Animals↗
PubMed1990

Coping and help-seeking in the UK adult population.

A large national sample of the UK adult population was surveyed to find out how respondents would cope and whom they would turn to for help if they experienced psychological problems. Overall, the most frequently endorsed coping methods were cognitive or behavioural rather than avoidance- or substance-based. Respondents tended to endorse informal rather than formal helpers, especially partners and close relatives, although the family doctor was given greater endorsement than in corresponding US studies. Individual differences in coping and help seeking were examined with respect to demographic variables and level of reported psychological symptoms. Respondents who reported higher levels of symptoms tended to endorse more coping methods, especially avoidance methods, and to show greater readiness to seek help. The implications of the findings for traditional clinical work and for mental health education and promotion are discussed.

Adaptation, Psychological↗
PubMed1988

Infusions of propofol to supplement nitrous oxide-oxygen for the maintenance of anaesthesia. A comparison with halothane.

The peri-operative and postoperative effects of propofol given by infusion were compared with halothane as a supplement to nitrous oxide-oxygen anaesthesia for body surface surgery in patients who breathed spontaneously. Anaesthesia was induced after opioid premedication, with either propofol 2.5 mg/kg or thiopentone 4-5 mg/kg which were followed respectively by an infusion of propofol 12 mg/kg/hour for 10 minutes and at a variable rate thereafter, or by halothane at a mean inspired concentration of 1.2%. Maintenance of anaesthesia required a median rate of infusion of propofol of 149.4 micrograms/kg/minute. The cardiovascular effects during induction and maintenance of anaesthesia were similar in the two groups. The overall incidence of side effects was low but immediate recovery was significantly faster in patients who received propofol.

Adult↗
PubMed1987

Clinical impact of stool cultures for Campylobacter in adults with acute or chronic diarrhea.

Campylobacter jejuni has emerged as a frequent cause of diarrhea. During a 12-month period at the Houston Veterans Administration Medical Center, we isolated C jejuni from 3.4% of the 290 stool cultures from patients with diarrhea. This compared to an isolation rate of 4.1% for Salmonella and 3.1% for Shigella. During the same period, 17 additional cases of Campylobacter-associated diarrhea were identified in adults at the two other Baylor College of Medicine teaching hospitals. We correlated the clinical history, treatment, and outcome of these 27 cases of Campylobacter-associated diarrhea (22 cases of acute diarrhea and five of chronic diarrhea). In most patients with acute disease, the diarrhea was resolving by the time the results of the cultures were available. The duration of illness was the same whether treated with antibiotics to which Campylobacter was susceptible (effective therapy) or antibiotics to which it was not susceptible (ineffective therapy); the mean duration of diarrhea after submitting the culture was 5.2 days for those with ineffective therapy versus 5.6 days for those receiving effective therapy. Thus, antibiotic therapy did not appear to shorten the duration of acute diarrhea due to Campylobacter. Five patients had chronic diarrhea; all had an unrelated underlying disease, and antibiotic treatment did not change the clinical course despite bacteriologic cure. This study raises questions as to the value of antibiotic therapy for campylobacteriosis, and in this light, we discuss the value of routine culturing for Campylobacter.

Acute Disease↗
PubMed1980

Plasma high density lipoproteins and coronary artery disease.

Plasma lipid samples and other atherosclerosis risk factors were related to presence of extent of coronary artery disease (CAD) in 102 consecutive patients undergoing coronary angiography. Thirty-six were without CAD and 66 had angiographically documented CAD. In CAD, high density lipoprotein (HDL) cholesterol was lower and total cholesterol and low density lipoprotein cholesterol were higher than in subjects without CAD. Further, HDL was inversely related to extent of CAD (number of major obstructed vessels). Moreover, decreased HDL was the single most important determinant of CAD among all atherosclerosis risk factors (more so in females than in males). In addition, reduced plasma enzymatic activity of lecithin:cholesterol acyltransferase (LCAT) correlated with the presence and extent of angiographically shown CAD. These findings document the protective effect of elevated plasma HDL against coronary obstructive disease and suggest this salutary action may be related to LCAT mobilization of cholesterol from atherosclerotic lesions.

Arteriosclerosis↗
PubMedDate not supplied

Lymphocyte content of amyloid precursor protein is increased in Down's syndrome and aging.

We quantified cellular amyloid precursor protein (APP) in ethanol-permeabilized peripheral lymphocytes from 13 subjects with Alzheimer's disease (AD), 11 subjects with Down's syndrome (DS), and 13 healthy elderly and 31 healthy young controls. APP content was analyzed by indirect immunofluorescence and flow cytometry, using the 22C11 monoclonal antibody (mAb) directed against an N-terminal domain of APP. Authenticity of 22C11 APP signal was confirmed by immunoblotting and flow cytometry studies with the mAb 6E10, directed against the A beta domain of APP. Consistent with gene dosage, patients with DS had 1.51-fold higher lymphocyte APP signal than age-matched normal young subjects (corrected p < 0.05). Both AD patients and elderly control groups had significantly increased lymphocyte APP signal compared to young controls (either comparison corrected p < 0.01). Indeed, increasing age in non-DS subjects was significantly correlated with lymphocyte APP (r = 0.508, p < 0.0001), such that APP immunoreactivity more than doubled from 20 to 80 years. Lymphocyte APP was nonsignificantly higher in AD vs. aged controls in this small sample. Increased cellular APP content in DS and aging may correspond to generalized alterations in expression or processing of this molecule, and suggests a novel determinant for the timing of AD onset.

Adult↗
PubMedDate not supplied

Effect of resistance training on cardiorespiratory endurance and coronary artery disease risk.

Coronary artery disease (CAD) represents a major medical problem in Western society and is a considerable cause of morbidity and mortality in South Africa. In recent years, epidemiologists have made extensive efforts to define the most common risk factors for CAD and propose preventative measures to limit the spread of the disease. Despite the increasing realisation of the importance of resistance training, the literature has focused primarily on aerobic modes of exercise and their effects on risk for CAD. The aim of this study was to determine whether resistance training could alter cardio-respiratory endurance (VO2max), and thus reduce CAD risk. A quantitative, experimental, comparative research design incorporating a pre-test, a treatment period and a post-test was used. Twenty-eight untrained male volunteers were age matched (mean age: 28 years and seven months) and randomly assigned to either a nonexercising control group (n = 15) or a resistance-training group (n = 13). The study demonstrated no statistically significant change in VO2max for the control group from their pre-test (25.097 ml/kg/min) to their post-test (23.778 ml/kg/min) (p = 0.201). However, resistance training significantly (p <or= 0.01) increased the VO2max from 26.674 ml/kg/min to 30.981 ml/kg/min (p = 0.004). Additionally, the difference between the pre- and post-test of the control and training group, respectively, demonstrated that the control group's mean VO2max was significantly lower than that of the resistance-training group (p = 0.001). Although not all studies have demonstrated significant increases in VO2max following resistance training, the results of this study showed that eight weeks of resistance training were sufficient to result in a significant improvement in VO2max. This suggests that an exercise programme that includes resistance training results in a composite of physical and physiological improvements necessary to impact favourably on risk for CAD.

Adult↗
PubMedDate not supplied

Consequence of resistance training on body composition and coronary artery disease risk.

Coronary artery disease (CAD) is a substantial cause of death and disability in South Africa and Western society, with research showing obesity to be one of the most common CAD risk factors. Furthermore, obesity is speculated to be the fastest-growing CAD risk factor and to become the most prevalent CAD risk factor. Research on obesity is therefore essential, and we propose some preventative measures that will hopefully limit the expansion of this risk factor for CAD. Most of the literature has focused primarily on aerobic modes of exercise. The aim of this study, therefore, was to investigate whether resistance training would improve body composition. Twenty-eight males were matched by age, percentage of body fat and waist-to-hip ratio and randomly assigned either to a resistance-training group (n = 13) or a control group (n = 15). Each subject's body mass, percentage body fat, lean mass, fat mass, waist-to-hip ratio and body mass index were assessed both pre- and post-experimentally following the eight-week experimental period. The resistance-training group trained three times weekly at 60% of their one-repetition maximum using nine resistance exercises. Each exercise was performed for three sets of 15 repetitions each, whereas the control group did not exercise over this period. The dependent t-test indicated that resistance training significantly changed body mass, percentage of body fat, lean mass and fat mass (all had a p-value of 0.00; p <or= 0.01). Furthermore, the independent t-test demonstrated that lean mass, fat mass and percentage of body fat were statistically significantly different between the control and resistance-training groups. In conclusion, resistance training improved four of the six measured body composition variables, therefore implying that resistance training does in fact improve the majority of body composition variables and therefore CAD risk.

Adult↗