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Biomedical subjects

I Sherwin

Publications and source records attributed to I Sherwin.

At least 19 recordsLinked to original sources
PubMed1986

Fingerprint pattern differences in early- and late-onset primary degenerative dementia.

The frequency distribution of major fingerprint patterns (ulnar or radial loops, arches, and whorls) was studied in 47 men with early-onset (aged, less than or equal to 64 years), 35 men with late-onset primary degenerative dementia (aged, greater than or equal to 65 years), and 100 control subjects (aged, 29 to 78 years). Patients with an early, but not those with a late, onset of dementia had significantly more ulnar loops than the control group. This finding, along with other data, is interpreted as indicating that there may be a biologic basis for distinguishing these two forms of dementia.

Aged↗
PubMed1984

Ictal-interictal unit firing pattern differences in penicillin-induced primary and secondary epileptogenic foci.

Single-unit activity occurring during seizures and interictal periods was studied in primary (penicillin) and secondary (mirror) neocortical epileptogenic foci in the rat. The results revealed that significant differences exist between the behavior of primary and dependent secondary focus neurons. The most prominent difference appeared to be the marked tendency for suppression of neuronal firing in secondary focus units, which was evident both interictally and during seizures. Moreover, seizures did not appear to be more potent than interictal discharges alone, in shifting the firing patterns of secondary focus neurons toward that displayed by primary focus neurons. These data have relevance for current theories regarding the induction of independent (chronic) secondary epileptogenic foci.

Animals↗
PubMed1984

Left-handedness in early and late onset dementia.

Sixty-five men with the diagnosis of dementia of the Alzheimer type were divided into two groups, according to age at onset of dementia before or after 65 years. A handedness questionnaire was then completed for each patient. There was a significantly higher prevalence of left-handedness in the early, as compared with the late, onset group. Taken together with other data, this finding suggests that presenile dementia (Alzheimer's disease) and senile dementia "of the Alzheimer type " may not be biologically identical.

Age Factors↗
PubMed1983

A comparison of clinical features in early- and late-onset primary degenerative dementia. One entity or two?

The prevalence of a number of clinical features occurring in patients with early- (before age 65) and late-onset primary degenerative dementia of the Alzheimer type (PDDAT) are compared. The data from a total of 65 patients demonstrated a greater prevalence of language disturbance, a disproportionate number of left-handers, and a much shorter relative survival time in the early-onset group. Taken together with other data, these findings indicate a degree of heterogeneity in the clinical features of patients with PDDAT and suggest a possible heightened selective vulnerability of the left hemisphere in early-onset cases. We interpret the data as raising the possibility that the current view of PDDAT as a unitary disorder may not be entirely valid.

Aged↗
PubMed1982

Prevalence of psychosis in epilepsy as a function of the laterality of the epileptogenic lesion.

Retrospective analysis of the psychiatric diagnoses in a group of patients surgically relieved of medically intractable epilepsy tested the hypothesis that patients with left-sided temporal lobe epileptogenic lesions are at greater risk for the development of a so-called schizophrenic-like psychosis than are those with right-sided temporal lobe epileptogenic lesions. The data confirmed the hypothesis and also demonstrated an increased prevalence of sinistrals in the psychotic group. Thus, epilepsy involving the dominant hemisphere at the inception of the seizure disorder is the significant risk factors. The data also indicated that a psychosis is unlikely to develop in patients with other (nontemporal) forms of focal epilepsy. On the basis of these data and data from other studies, the prevalence of psychosis in patients with poorly controlled temporal lobe epilepsy was estimated to be approximately 10% to 15%.

Adult↗
PubMed1978

Interictal--ictal transition in the feline penicillin epileptogenic focus.

A study was undertaken to examine those EEG features which characterize interictal--ictal (II--I) transitions in the feline penicillin focus. The study describes certain complex changes in spike frequency and their statistical analysis, which appear to have predictive value in signaling II--I transitions. The significance of these data with respect to the conflicting results of other studies and their possible application to clinical epilepsy are discussed.

Animals↗
PubMed1978

"Organic brain syndromes": an empirical study and critical review.

The authors found that all but 3 of 80 randomly chosen patients in a Veterans Administration hospital who had been given a primary nonspecific neuropsychiatric diagnosis (organic brain syndrome, organic psychosis, chronic brain syndrome, etc.) could be assigned to specific diagnostic categories. Diagnosis was based on chart review and thorough neurological and clinical evaluation. Senile and alcoholic dementia and Korsakoff's syndrome were seen most often, and 15% of the patients were diagnosed as having functional disorders of the mental state. The authors review the organic brain syndrome diagnosis in light of this and other evidence. They believe that fractionation into more specific diagnoses is essential to further understanding of this group of diseases. Use of the general term can result in inappropriate or no treatment; further, it hampers essential psychological, pharmacological, and biomedical research on these disorders.

Adult↗