PubMed Health⌕ Search

Biomedical subjects

I Shiozawa

Publications and source records attributed to I Shiozawa.

At least 19 recordsLinked to original sources
PubMed1998

[A survey on condition of outpatients at prosthodontics II, University Hospital, Faculty of Dentistry, Tokyo Medical and Dental University].

The number of dental patients who have medical illnesses is increasing at the hospital of the Faculty of Dentistry, Tokyo Medical and Dental University. Although prosthodontic treatments are considered less invasive in all dental treatments, invasive procedures such as tooth extraction may be required occasionally. Therefore, it is necessary to treat patients in consideration of their condition. Under this situation, a clinical survey was conducted by health questionnaires answered by the patients who visited our clinic between October 1992 and March 1997. The number of patients whose illness was heart disease, hypertension, diabetes, nephritic disease, hepatitis, tuberculosis, hemodyscrasia, asthma, epilepsy, and so on during dental treatment was higher than the national average according to the Ministry of Health and Welfare. Dental psychosomatic diseases such as TMD and dental phobia were increased every year. These data reflect the contemporary disease structure in Japan characterized by the spreading of life-style related diseases and increase of neuropsychological and infectious diseases.

Adolescent↗
PubMed1997

A comparison of in vivo and in vitro strain with posterior fixed partial dentures.

PURPOSE: Deformation of fixed partial dentures during function has been related to clinical failures. However, such deformation has not been measured quantitatively, and the effect on deformation of the viscoelastic behavior of peridental structures is not well understood. The purpose of this study was to determine the strain distribution of fixed partial dentures during function and to compare the biomechanical behavior of fixed partial dentures in vivo and in vitro. MATERIAL AND METHODS: Three conventional posterior fixed partial dentures and two complete crowns were fabricated. Both in vivo and in vitro strain measurements of each of the five prostheses were recorded by a strain gauge method. A static load was produced through occlusal force in vivo and with a universal testing machine in vitro. RESULTS: The resulting difference between the strain distribution for the two crowns in vivo and in vitro was negligible, but the whole fixed partial denture demonstrated a substantial amount of strain in vivo. CONCLUSIONS: The results of this study suggest that serious problems with strain may occur in a long-span mandibular posterior fixed partial denture.

Adult↗
PubMed1989

Radiosensitivity test for cancer of the uterine cervix.

In selecting the method of treating uterine cervical cancer, radiosensitivity is one of the most important factors. To know this factor before treatment, we are trying to estimate radiosensitivity with changes of primary tumors before and after the irradiation. Tumors must be irradiated uniformly with small doses, and based on these considerations, we are attempting external test irradiation for estimation of radiosensitivity. Radiosensitivity was determined histopathologically by comparing the results of histological specimens taken before and seven days after test irradiation. Radiosensitivity is closely related to prognosis: of 183 cases with good sensitivity, 146 cases (79.8%) were surviving at five years after radiotherapy. On the other hand, the five-year survival rate of cases with poor sensitivity was only 37.2%. Comparing radiation with operation in operable cases of stage I and II, the five-year survival rate in cases with good sensitivity was about the same (90%). On the contrary, in cases with poor sensitivity, there was a substantial difference: that is, 66.0% of operated cases had a five-year survival compared with 39.7% of radiated cases.

Female↗
PubMed1988

Uterine body invasion of carcinoma of the uterine cervix as seen from surgical specimens.

To estimate the actual states of uterine body invasion of carcinoma of the uterine cervix, 301 radically hysterectomized specimens were reviewed histologically. Incidence of uterine body invasion was 21.6% in all cases (65 cases out of 301), 7.8% in stage Ib, 25.5% in stage IIa, and 38.2% in stage IIb. Most of the positive invasion cases had spread to other surrounding tissues. Vaginal wall was invaded in 58.5% of all positive cases, parametrial infiltration was recognized in 87.7%, and pelvic lymph node metastasis was seen in 52.3%. On the contrary, in negative cases these were 33.9, 19.1, and 15.7%, respectively. There was a higher incidence of the L type of Imai's CPL classification among positive cases of uterine body invasion than among negative cases (81.5% vs 38.1%). When cervical cancer spread into the uterine body, peritoneal carcinomatosis and distant metastasis increased. Thus the outcome of patients with positive invasion was, naturally, poor. Patients with negative invasion had a 5-year survival rate of 92.4%, compared to 53.8% in patients with positive uterine body invasion. These results suggest that uterine body invasion of carcinoma of the uterine cervix is an important prognostic factor and treatment should be modified in such cases.

Adenocarcinoma↗
PubMed1987

Pelvic lymph node metastasis of uterine cervical cancer.

The state of pelvic lymph node metastasis was observed in 627 cases of Okabayashi's radical hysterectomy performed from 1950 to 1984 of which 589 cases with a known 5-year survival rate were examined according to their relationship to prognosis. The incidence of lymph node metastasis was 29.7%, becoming progressively higher with succeeding clinical stages. The metastasis rates according to site were 6.9% hypogastric nodes, 4.9% obturator nodes, 4.4% iliac nodes, and 25.0% parametrial nodes. Among the factors considered in the postoperative classification, lymph node metastasis demonstrated high values in cervical infiltration cancer, positive parametrial infiltration, positive vaginal invasion, and infiltration into the uterine body and L type of CPL classification. The 5-year survival rate was 83.0% in negative cases of pelvic lymph node metastasis, while in positive cases, it was as poor as 45.8%. Considering the relationship of various factors, it is shown that the presence of lymph node metastasis has a great effect on prognosis.

Female↗
PubMed1983

[Significance of serum immunosuppressive substance (IS) levels in the field of gyneco-obstetrics].

To investigate the immune responses of patients with cancer, we assayed a newly found immunosuppressive substance (IS) by the single radial immunodiffusion method. This substance is extracted from ascites of colon cancer. The IS average level in 46 healthy women was 555.4 +/- 112.1 micrograms/ml. The normal upper limit should be 800 micrograms/ml. Seventy cases with uterine cervical cancer had a significantly higher IS level (667.0 +/- 189.8 micrograms/ml) than healthy women (t=3.57, p less than 0.001), especially in Stages III & IV. All 28 patients except one with recurrent cancer showed an IS level higher than 800 micrograms/ml. (1431.7 +/- 480. 9 micrograms/ml). Before recurrence was found clinically, the IS level became higher. In ovarian tumors, assay of the IS level yielded an interesting result: In 16 cases with benign tumors the level was 568.8 +/- 109.7 micrograms/ml. On the other hand, nine patients with ovarian cancer had levels over 800 micrograms/ml. These data suggest that the assay of IS substance may be useful for the staging of uterine cervical cancer, early detection of the recurrence, differentiation between benign and malignant ovarian tumors and so on.

Abortion, Spontaneous↗
PubMed1982

Study on the histogenesis of ovarian tumors--with special reference to five clinical cases with common epithelial tumors detected during the preclinical stage.

Common epithelial tumors of the ovary, which were found during the preclinical stage in the 5 cases were described, and the histogenesis of ovarian tumors was discussed. 1. All the ovaries in the 5 cases maintained a nearly normal external appearance. As regards the cut surface, 3 cases showed gross-observable tumor mass, and 2 cases had microscopically detectable tumor tissues. All of these tumors were solid, and the cyst formation was not evident to the macroscopical examination. 2. Three cases were serous tumors, and the other 2 cases were of the endometrioid type. Two cases were malignant, and 3 cases were LPM. In two of the cases, the pictures which appeared to correspond to the early stage picture of the unclassified tumor were observed. 3. Non-tumoral inclusion cysts were observed in 4 cases, and the majority of them showed some growth activities. In 2 cases out of these 4, the transient pictures from the active inclusion cyst to the tumor were observed. 4. Tumorgenesis was multicentric based on inclusion cysts, and the tumor proliferated with spreading inside the lymph space in the ovary. The formation of the small cyst and the proliferation in a papillary form were the basic pattern of the tumor.

Adenocarcinoma↗
PubMed1981

A histological study on immune reaction of advanced uterine cervical carcinoma with regard to the effect of a low-dose irradiation and PS-K.

Histopathological studies were carried out to determine whether or not an immunological reaction was involved in the treatment of cervical carcinoma. The following conclusions could be drawn from them. (1) A low-dose irradiation on the primary cancer-nest intensified the interstitial reaction. (2) When PS-K was administered after low-dose irradiation, the interstitial reaction was intensified more remarkably than with irradiation alone. Moreover, it was possible for PS-K administration to restore the responsiveness of lymph nodes which had been inhibited by the irradiation. (3) Some of the observed morphological changes suggested the local occurrence of an immunological reaction. The following findings could be pointed out: (a) In the primary lesion of the uterine cervix, exudative cells consisting mainly of lymphocytes, plasma cells, and macrophages formed a barrier-like layer surrounding the cancer-nest. Granuloma accompanied by foreign-body type giant cells were formed in the interstitial tissue. Moreover, lymphoid tissues with a germinal center were formed. (b) In lymph nodes of the region involved, responsiveness was enhanced in the paracortical area, or a germinal center formed with its responsiveness enhanced. (4) There was a correlation between the degree of interstitial reaction of the primary lesion and the survival results of a follow-up survey. There was also a correlation between the degree of enlargement of lymph nodes and the survival results of this survey.

Female↗
PubMed1981

[Studies on parametrial infiltration of uterine cervical cancer (author's transl)].

It is clear that the prognosis of uterine cervical cancer depends on the spread of cancer, especially lymphnodes metastases and parametrial infiltration. The correct diagnosis of parametrial infiltration before treatment is, however, difficult and there are many over- and under-diagnosis. In this paper, we discuss the details of parametrial infiltration based on the radically hysterectomized specimens in Shinshu University Hospital from 1964 to 1978. In these period, 284 cases of uterine cervical cancer were operated by Okabayashi's radical hysterectomy and our postoperative classification were carried out. The results were as follows; 1) The incidence of parametrial infiltration were 16.4 in Stage Ib, 36.6% in Stage IIa, 57.5% in Stage IIb and 35.6% in all cases. 2) When divided the parametrial tissue into three parts, we could find carcinomatous infiltration into uterine part in 77.3% of positive cases, middle part in 16.2% and pelvic part in 16.2%. 3) The agreement between clinical diagnosis and histological findings were 72.2% in all cases. 4) The CPL classification had close relation with parametrial infiltration (C type; 0%, P type; 17.9%, L type; 61.8%). 5) The 5-year survival rate of patients with infiltration showed poor outcome (63.0% in 81 cases), but that with no infiltration had good prognosis (98.4% in 128 cases). In conclusion, parametrial infiltration is very important for treating the uterine cervical cancer patients.

Adnexa Uteri↗
PubMed1980

[A study on the correlation between immune responses and histopathological changes of primary lesion in patients with cervical cancer following radiation therapy (author's transl)].

From an immunological viewpoint, histological changes of stromal cell reactions and regional lymph nodes were observed in uterine cervical cancer patients who received test irradiation. Delayed cutaneous hypersensitivity reaction, peripheral lymphocyte blastoid transformation, and peripheral lymphocyte subpopulations were also studied. 1) The variation of stromal reaction after test irradiation was analogous to that of delayed cutaneous hypersensitivity. 2) There was a significant correlation between the degree of stromal reaction and skin reactivity to PPD and PHA. Stromal reaction increased in proportion to PPD skin reactivity after test irradiation. 3) The degree of stromal reaction was not correlated with the ability of lymphocyte blastoid transformation and peripheral T-lymphocyte counts. 4) The prognosis was good in the cases that showed marked stromal reaction and greater enlargement of the regional lymph nodes. 5) The radiosensitivity score was correlated to PPD skin reactivity. From these observations, it was presumed that the host immunity had an effect on the curative course of uterine cervical cancer and stromal reaction was one of the histological parameters that demonstrated immune reactions.

Cervix Uteri↗
PubMedDate not supplied

Deformation of restoration and fracture of luting cement film.

OBJECTIVES: Functional occlusal loading can generate complicated stresses in the luting cement film between a restoration and its abutment. Such stresses may lead to cement fractures, which can promote cement dissolution and induce clinical problems. The purpose of this study is to determine the function of the cement film under loading, and to clarify the relationship between the deformation of the restoration and the cement fractures. METHODS: Eccentric loads were applied onto model extension bridges which were cemented on brass dies with zinc phosphate cement. Strain measurements were recorded using of a strain gauge method, ultimate strength by tensile tests, leakage by dye penetration tests and cement fractures by ultrasonic microscopic analyses. Additionally, the bridges which were just seated on their dies without cementation were loaded, and strain measurements were recorded. RESULTS: The cases for linear strain increment with loading showed high tensile strength and minimal dye penetration. The cases with non-linear strain behavior showed low tensile strength and considerable dye penetration. However, no fracture was observed in the occlusal cement film in both cases. The cement fracture first occurred at the opposite marginal region to the loading side. CONCLUSIONS: One of the significant functions of the cement film is diminishing the deformation of restorations during loading. The deformation of the restoration affects initiation and propagation of the cement fracture considerably.

Alloys↗