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Biomedical subjects

I Siebenbrodt

Publications and source records attributed to I Siebenbrodt.

4 recordsLinked to original sources
PubMed1990

[Preparations of preoral sustained-release preparations with a biological polymer base. 5 (correct title supplied from Table of Contents)].

Triethylamine and chloroacetic acid were used for the preparation of polyglycolic acid. The polyester was characterized by elementary analysis, IR-spectroscopy, X-ray-test and the determination of the molecular mass. With regard to the pharmaceutical and technological characterization the determination of the grain size, moisture content, flowability and the parameters for the direct compression were carried out. Polyglycolic acid was compressed together with caffeine as model drug. These tablets distinguished by a great strength, but in water a rapid decay took place. A greater stability in artificial gastrointestinal fluids was obtained, if the tablets were plastified. Release investigations showed then the desired retard effect.

Acrylic Resins↗
PubMed1990

[Antiglaucoma ophthalmic agents with prolonged action with based on macromolecular excipients. 3. Optimized drop preparation on a polyacrylate base].

In contrast to the standardized product Carbopol 940, polyacrylic acid-Fluka (PAS-F, a copolymerized product of acrylic and methacrylic acid) can form liquid preparations, which have weak acid pH values from 5.3 to 6.5. Such pH-values are euhydric pH-values of many medical substances. Different PAS-F-preparations were developed and their physical-chemical parameters were characterized. 3.5% PAS-F and pilocarpine or carbachol containing preparations have suitable viscosities from 18 to 72mPa.s. According to in vitro tests, these preparations showed a significantly prolonged release of the drugs compared to the aqueous solutions. In human tests, the physiological compatibility of PAS-F-preparation was proved and the drug action was prolonged as well as the drug intensity was increased compared to the aqueous solutions of drugs.

Acrylic Resins↗
PubMed1989

[Optimizing electrode contact with adhesive agents].

An evaluation of three hydrogel-forming substances carboxylmethylamylopectine sodium, carboxymethylcellulose sodium, hydroxyethylcellulose used in the G.D.R. is presented in respect of their quality to form a electrodes-fixing gel. Useful compositions were tested on their fixation-power, physiological compatibility, decreasing of skin-resistance, oppression of interferences and preparation consistence during six month. A gel consisting on 15% hydroxyethylcellulose, 20% glycerol, 0.9% sodium chloride and 64.1% preserved water has been accepted as useful for storage and for an interferenceless conduction of biopotentials for several hours.

Adhesives↗