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Biomedical subjects

I Simek

Publications and source records attributed to I Simek.

At least 19 recordsLinked to original sources
PubMed1993

Adequate enzymatic substitution in treating exocrine pancreatic insufficiency.

The chymotrypsin in the stool test was used to monitor adequate enzymatic substitution in treating exocrine pancreatic insufficiency with 18 patients (16 suffering from chronic pancreatitis and 2 having passed duodenopancreatectomy due to pancreatic cancer). This test helps to identify pancreatic insufficiency and can be successfully used in monitoring the adequate amount of pancreatic substitute, which, we have found, differs from patient to patient. The dosage can be higher in cases of chronic pancreatitis than in those required after duodenopancreatectomy.

Amylases↗
PubMed1993

[Appearance and symptoms of giardiasis in the Olomouc region].

A group of 118 patients, aged 1-73 years, suffering from giardiasis in their gastrointestinal tract was studied in the period of 1988-1990. The analysis consisted in determination of frequency, sex distribution, age categories and incidence within the period of 12 months. Patients older than 15 years were asked about the possible sources of infection, subjective and objective symptoms and therapy. The information obtained for our region were compared with data reported in literature.

Adolescent↗
PubMed1993

[Substitution therapy in insufficient external pancreatic secretion].

For assessment and monitoring of adequate enzymatic substitution the authors used repeated examinations of chymotrypsin in the faeces of 19 patients with insufficiency of external secretion (17 patients with chronic pancreatitis and two after duodenopancreatectomy on account of carcinoma of the pancreas). Adequate substitution (chymotrypsin > 6U/g faeces) is individual (1.8-7.2 g pancreatin--Kreon/day). The required dose may be higher in patients with chronic pancreatitis than in conditions following duodenopancreatectomy. When receiving adequate substitution treatment, the patients reported milder complaints, regression of pain and diarrhoea. In two patients with severe signs of malnutrition a satisfactory condition was achieved and their loss of body weight was arrested. The necessary dose of insulin in diabetic patients declined by 4-12 u/day. During treatment no adverse side-effects were found.

Adult↗
PubMed1992

Adequate enzymatic substitution in treating exocrine pancreatic insufficiency.

The chymotrypsin in the stool test was used to monitor adequate enzymatic substitution in treating exocrine pancreatic insufficiency with 18 patients (16 suffering from chronic pancreatitis and 2 having passed duodenopancreatectomy due to pancreatic cancer). This test helps to identify pancreatic insufficiency and can be successfully used in monitoring the adequate amount of pancreatic substitute, which, we have found, differs from patient to patient. The dosage can be higher in cases of chronic pancreatitis than in those required after duodenopancreatectomy.

Adult↗
PubMed1992

[Present possibilities of prenatal diagnosis of Fabry's disease].

Fabry's disease (angiokeratoma corporis diffusum universale) is an inborn error of metabolism, which is based on a shortage in the cumulation of glycosphingolipids in endothelial and epithelial cells of glomeruli, vascular endothelia and in ganglion cells with subsequent severe organ damage. Heredity is X-linked recessive. In the submitted paper the authors present a case-history of a family where three men were affected and carriership was confirmed in five women. During the first pregnancy one of them a successful prenatal diagnosis was made from cultivated amniotic fluid cells. Chromosomal examination revealed female sex and the levels of the alpha-galactosidase A were established in cultivated cells. A healthy girl was delivered.

Adult↗
PubMed1981

[Ultrasonic diagnosis of gastrointestinal diseases].

The authors describe their experiences with the ultrasound tomography (compound scan and real-time scan) on the basis of 2,360 own examinations. This examination method was particularly suitable in cholelithiases, in concrements of the choledochus, in diseases of the pancreas above all in different forms of pancreatitis and pancreatic tumours and in abdominal lymphomas. The authors emphasize the advantages of the non-invasive method, however, they recommend to valuate the ultrasonographic findings always taking into consideration all other results of clinical examinations.

Cholelithiasis↗
PubMed1980

[Fabry's disease].

Case reports on three patients with Fabry's disease. Two of them involved necroptic examination, in one case the authors examined bioptic specimens of a 9-years old boy's skin. The material was processed by light microscopy, by electron microscopy, and by chromatography [in one case]. The two fatal cases showed accumulation of glycolipid mainly in cardiac muscle cells, the cause of heart failure. The authors describe the morphology of granules and give a list of their tinction and histochemical properties.

Adult↗