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Biomedical subjects

I Sjögren

Publications and source records attributed to I Sjögren.

At least 55 records · Page 3Linked to original sources
PubMed1979

Primary sclerosing cholangitis associated with fibrosis of the submandibular glands and the pancreas.

A new syndrome of primary sclerosing cholangitis associated with fibrosis of the submandibular glands and the pancreas is described in a 43-year-old male. The sclerosing cholangitis was diagnosed at laparotomy because of cholestasis and the fibrosis of the submandibular glands and pancreas confirmed at microscopical investigation of biopsy specimens. The cholangitis responded well to treatment with a low dose of prednisolone (7.5--10 mg) and an endoscopic retrograde cholangiopancreaticographic examination 10 months after the operation revealed normal bile ducts.

Adult↗
PubMed1979

Bone mineral content in the proximal tibia measured by computer tomography.

With a slight modification of the EMI MK1 scanner a sensitive method for examination of the bone mineral content in the proximal tibia was achieved. The method allows an estimation of the amount of trabecular and cortical bone as well as their mineral content. The anatomic structure of the bone substance is demonstrated, differing in osteoporosis and osteomalacia. The reproducibility is acceptable.

Bone and Bones↗
PubMed1978

Bovine tuberculosis in man--reinfection or endogenous exacerbation.

Cattle tuberculosis was totally eradicated in Sweden 20 years ago. Twelve cases of bovine tuberculosis in man were reported in 1974 and 1975. All cases lived for many years in areas where cattle tuberculosis had previously been common. No recent source of infection could be demonstrated. These findings are in accordance with an exacerbation of a distant infection.

Adult↗
PubMed1976

Tuberculosis in BCG-vaccinated and unvaccinated young Swedish Men. A comparative study.

Tuberculosis causing exemption from military service was studied in 47,791 tuberculin-tested military recruits between 1941 and 1946. A total of 46.6% were tuberculin negative, and two-thirds were BCG vaccinated. An analysis was made of 304 cases of tuberculosis discovered from 6 months after the test up to the end of 1960. It has been calculated that 69% of "expected cases" of tuberculosis were in the BCG-vaccinated men during the 5-year period after the test, and 20% during the following period; 46% of "expected cases" of post-primary pulmonary tuberculosis and 83% of "expected" deaths were prevented. The differences on which these percentages are based were statistically significant. The efficacy of BCG vaccination was lower in areas with widespread cattle tuberculosis than in areas where cattle tuberculosis is less frequent; this is explained by the influence of previously acquired immunity.

Adult↗
PubMed1975

The risk of tuberculous infection in Sweden.

Large sections of the population of Sweden were tuberculin tested during the 1940s prior to BCG-vaccination. This material has been used to estimate the risk of tuberculous infection and its trends with calendar year and age. An analysis of the results of approximately 200,000 tuberculin tests in military recruits and schoolchildren was made, using the method developed in the Tuberculosis Surveillance Research Unit. The risk of infection was estimated to be 2-8 per cent at age 10 in 1935, the rate decreasing by 9-0 per cent annually. There was also a substantial increase in the risk with each year of age, amounting to 8-6 per cent for each year of age. Separate analyses of the risk of infection and its trend with time for each of the individual 24 counties and the city of Stockholm, showed considerable variations in the level of the risk between the different areas. These are related to variations in tuberculosis in cattle in a further report. In seven areas information was available from earlier surveys in schoolchildren or recruits, using the same method of testing. In these areas separate estimates of the calendar trend of the risk of infection and the age trend have been made. The decrease in the risk with calendar year and the increase with age seem to apply in each of these counties, as in the whole of Sweden. The reliability of the findings was tested by comparing the estimated risk of infection for the whole of Sweden and the tuberculous meningitis mortality rate in children aged 0-4 years between 1925 and 1935. There was a similar trend in the risk and in the mortality rate. Between 1935 and 1940 the decline in the tuberculous meningitis mortality rate became steeper, and amounted to about 11-5 per cent annually between 1935 and 1945. Special measures for the protection of uninfected but exposed children became increasingly common during the 1920s and 1930s, and these were supplemented with BCG-vaccination at a later date. From July 1939 all milk sold for human consumption had to be pasteurised. It is suggested that all these factors may have contributed to the more rapid decrease in the tuberculous meningitis mortality in young children after about 1938.

Adolescent↗
PubMed1975

Studies of tuberculosis in man in relation to infection in cattle.

A study has been made in Sweden to investigate whether the risk of tuberculous infection and its trend with time in man in different areas were related to varying prevalences of tuberculous infection in cattle. It was found that the level of the infection risk in man was related to the prevalence of tuberculous infection in cattle, varying from 3-4 per cent in 1935 at age 15 in counties with less than 2 per cent infected cattle to 5-8 per cent in counties with 20 per cent infected cattle or more. However, the downward trend to the risk of infection with time was not to found be associated with the prevalence of tuberculous infection in cattle. The correlation between the risk of infection in man and the prevalence of infection in cattle in the 24 Swedish counties was positive and highly significant (+0-79). The relationship between cattle tuberculosis and tuberculosis in man was further studied by correlating infection in cattle with tuberculosis mortality and morbidity in man. The correlation with mortality was negative and highly significant (-0-77), i.e. counties with little cattle tuberculosis had a high tuberculosis mortality in man, and vice versa. There were similar large negative correlations with measures of tuberculosis incidence. When variations between the counties in relevant environmental factors, namely capital, urbanization and overcrowding, were taken into account, a strong positive association remains between the prevalence of infected cattle and the risk of tuberculous infection in man, but the associations with tuberculous mortality and morbidity, though they remain negative, become weaker. It is suggested that the probable explanation of these findings is the long-term protection against adult infection with human tubercle bacilli conferred by bovine infection in childhood.

Adolescent↗
PubMed1974

Preparative fractionation of triglyceride mixtures according to acyl carbon number, using hydroxyalkoxypropyl Sephadex.

The present paper describes the use of hydroxyalkoxypropyl Sephadex in a liquid chromatography system. When the column is held at 40 degrees C, and when elution is made with a linear gradient of two solvents, an excellent separation of saturated triglycerides in the region C(9)-C(56) is obtained in 24 hr, even with sample loads as high as 0.5 g/cm(2) of column. Triglycerides containing unsaturated fatty acids are eluted more rapidly than their saturated homologs, one C-C double bond being equivalent to -1.42 fatty acid carbon atoms.

Butter↗