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Biomedical subjects

I Sodja

Publications and source records attributed to I Sodja.

5 recordsLinked to original sources

[Epidemiology of rabies in the Czech Republic].

In 1976 to 1988 on average some 4,323 +/- 482 subjects in the Czech Republic (i.e. 42.6 +/- 7.6/100,000 population) had contact with rabid or suspect animals, i.e. with dogs (73.3%), cats (15.9%), foxes (4.2%), other wild beasts (1.4%) and other animals (6.2%). Data on contact with suspect animals reported from different regions varied greatly. Post-exposition prophylaxis was started on average in 25% of the exposed subjects after contact with dogs in 44.5%, with cats in 24.7%, foxes in 12.6% and with other animals in 18.1% of the treated subjects. Groups of subjects exposed to the same animal (most frequently a cat or dog) or consumption of meat of infected animals accounted for 8% of all vaccinated subjects. During the period between 1974 and 1988 3,852 (22.9%) of exposed 16,845 subjects were treated in anti-rabies centres. From a group of 5,499 subjects 4,013 (73.0%) were injured: 1203 (21.9%) by a known (296, i.e. 5.4% by a rabid) and 2,810 (51.1%) by an unknown animal and the remainder of 1,486 subjects were exposed to suspect animals without being injured--in 1,154 cases (21.0%) to a known (958, i.e. 17.4% positive) and in 232 cases (6.0%) to unknown animals. Foxes accounted in indication for post-exposure prophylaxis for less than 10% and injured only for 1.1% of the vaccinated subjects. In anti-rabies centres most frequently subjects of productive age (44.7%) and school age (24.8%) were treated. The male/female ration was 3:2. Prophylaxis was started within 48 hours after exposure in 45% of the subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals

Antigenic variation in rabies virus strains.

Several rabies virus isolates from small wild rodents, one strain isolated from a fox and another from a cat, as well as the CVS strain were compared in cross-protection and virus-neutralization tests. Antigenic variations between the strains and between different batches of individual strains were found. These antigenic differences could not be explained by denaturation caused by UV irradiation or deep-freeze storage, by the presence of "incomplete" particles or by passage in immune organism. An antigenic difference was batch-specific and was only demonstrable on comparison with a relatively large number of strains: it has probably developed during the assembly of antigenic determinants of the virion. There was no correlation between protective and virus-neutralizing activities.

Animals

Early events in non-lethal rabies infection.

Inoculation of sublethal doses of rabies virus strains isolated from small wild rodents resulted in non-lethal infection of white mice. During the first 48 hr after inoculation the virus neutralizing and protection activities in mouse sera and brain suspensions increased, followed by a transient decrease on the 3rd and 4th day. In some cases there also occurred transient multiplication of virus, which retained a relatively high infectivity for mice.

Animals

Interferon production by rabies strains isolated from wild rodents.

Eight rabies strains isolated from wild rodents produced interferon in laboratory mouse brains the second day after inoculation. Low levels of interferon were also detected in the serum, kidneys and lungs of the animals. The dosage and route of inoculation had no pronounced effect on interferon production.

Animals