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Biomedical subjects

I Stornes

Publications and source records attributed to I Stornes.

8 recordsLinked to original sources

[Management of prolonged pregnancy in Denmark. A questionnaire study].

In order to describe how post-term pregnancy was managed in Denmark, a questionnaire was sent to all 50 maternity departments with a 100% response rate. Thirty-nine departments managed post-term pregnancy; twenty-one departments conservatively (i.e.expectantly) and 18 departments with induction of labour. Cardiotocography in the surveillance of the foetus was routine in 35 departments; 21 departments monitored with ultrasound and 18 used human placental lactogen. Gestational age was confirmed by ultrasound before 20th week of gestation in nine of ten departments with > 2000 births per year, in four of 19 departments with 1000-2000 births per year, and in five of ten departments with < 1000 births per year. Ten departments which managed post-term pregnancy by induction did not routinely confirm gestational age by ultrasound. Danish obstetricians differ in their management of post term pregnancy. Cumulative data from prospective, randomized studies can be interpreted as showing an active policy of induction to be advantageous. A large multicentre study is difficult, but desirable in order out to discuss for and against induction or expectant management.

Denmark↗

A phase II trial of ifosfamide, 5-fluorouracil, and leucovorin in recurrent uterine cervical cancer.

Thirty patients with recurrent squamous cell carcinoma of cervix uteri no longer amenable to control with surgery and/or radiotherapy were treated with a combination of ifosfamide, 5-fluorouracil, and Leucovorin every 4 weeks. The response rate was 53% (complete response, 33%; partial response, 20%). Response rates outside and inside irradiated area were 68 and 27%, respectively. The median progression-free interval was 7 months, and the median overall survival was 12 months. Adverse effects included primarily leukopenia, and dose reduction was necessary in 18 patients (60%). The present combination is active in the treatment of recurrent cervical cancer with a high response rate. The long-term survival is however still unsatisfactory.

Adult↗

Renal malignancy in von Hippel-Lindau's disease. Case reports.

We present our experience with 4 patients with von Hippel-Lindau's disease. They all had asymptomatic renal malignancy, and three patients had bilateral tumors. None of the patients had metastases from their renal tumors, but two patients had developed new tumors which demanded surgery. Abdominal computerized tomography was first choice in the initial evaluation, eventually supplemented by renal angiography. The treatment should be conservative, but bilateral nephrectomy and hemodialysis may be required. Screening of at-risk family members and close and lifelong follow-up is emphasized.

Adenocarcinoma↗

Chemotherapy in perineal leiomyosarcoma.

A case report of a woman with perineal leiomyosarcoma who was cured by combination chemotherapy is presented, and the literature on chemotherapy of soft tissue is reviewed.

Antineoplastic Combined Chemotherapy Protocols↗

A comparison of Lamicel tents and gemeprost (Cervagem) pessaries prior to first trimester abortion.

In an open, randomized study 108 women were treated with either a Lamicel tent or a 1 mg gemeprost pessary (Cervagem) 4 h before first trimester abortion. Both treatments were effective in producing cervical dilatation, however further dilatation was significantly easier after Cervagem. Preoperative abdominal pain and gastrointestinal side-effects were significantly more frequent in the Cervagem group. The incidence of postoperative pain and blood loss were similar in the two groups. Advantages and disadvantages of the two treatments are mentioned.

Abortifacient Agents, Nonsteroidal↗

[Fertility after extrauterine pregnancy. A 16-year retrospective study].

A retrospective investigation of fertility following extrauterine pregnancy during a period of 16 years in a central hospital was carried out. Out of 283 women with extrauterine pregnancy, if proved possible to investigate the postoperative fertility in 181 women. It was found that 71.8% of the patients conceived and 49.2% were delivered of living infants while 16% developed renewed extrauterine pregnancies. No significant differences were found in the frequencies of renewed extrauterine pregnancy and the number of liveborn infants between women who had been submitted to radical operation and women in whom conservative operative methods were employed. On the basis of this investigation and review of the literature, the present authors consider, that conservative operation should be employed where this is technically possible.

Female↗