PubMed Health⌕ Search

Biomedical subjects

I Sudo

Publications and source records attributed to I Sudo.

At least 19 recordsLinked to original sources
PubMed1993

[Significance of quantitative and qualitative analysis of fecal alpha 1-antitrypsin in gastric cancer patients].

The levels of fecal alpha 1-antitrypsin (alpha 1-AT) were significantly high in advanced gastric cancer patients, compared with those in healthy control subjects and early gastric cancer patients. As the background, a process was assumed that excessive alpha 1-AT which flowed into the stomach through the cancerous lesion is saved from rapid proteolysis in the gastric juice of hypoacidity and proceeds to the small intestine. A molecular weight 38000 form of alpha 1-AT was detected in all of the stools of the control subjects and the gastric cancer patients by Western blotting analysis, and which was shown to lack its sugar chain by crossed immunoelectrophoresis (CIE) and crossed immuno-affino-electrophoresis (CIAE) analysis.

Adult↗
PubMed1992

Treatment of intraoperative hypertension with enflurane, nicardipine, or human atrial natriuretic peptide: haemodynamic and renal effects.

The purpose of this study was to assess the effects of the calcium entry blocker nicardipine and alpha human atrial natriuretic peptide (hANP) on antihypertensive and diuretic activity in hypertensive surgical patients. The site of the diuretic actions of these drugs along the nephron were also investigated by measuring the excretion rate of inorganic phosphate (PO4). Hypertension during gastrectomy was treated by increasing the concentration of enflurane, by nicardipine infusion (0.5-2.0 micrograms.kg-1 x min-1), or by hANP infusion (0.05-0.2 microgram.kg-1 x min-1) under general anaesthesia. Enflurane, nicardipine and hANP all decreased arterial pressure to the same extent. Urine flow, Na and PO4 excretion increased following the administration of nicardipine or hANP. Fractional distal reabsorption of sodium was suppressed from 89.7 +/- 2.8% to 82.1 +/- 5.0% by the hANP, but not by the nicardipine infusion. Creatinine clearance was increased by hANP infusion, but did not change in the nicardipine group. It is concluded that nicardipine and hANP can be used safely for the treatment of hypertension during surgery. Both drugs induced phosphaturic diuresis, but the site of action of the two drugs on the nephron may be different. Phosphate reabsorption is considered to occur largely in the renal proximal tubule, so that its appearance in the urine in increased quantities without the change of renal circulation in the nicardipine group suggests a proximal tubular action of this drug. However, the site of action of hANP in the kidney was not determined because GFR increased and distal sodium reabsorption was suppressed due to the drug infusion.

Absorption↗
PubMed1991

[Nicardipine inhibits phosphate reabsorption regardless of glomerular filtration rate in hypertensive surgical patients].

The author investigated the mechanism of diuretic effect of a calcium entry blocker of dihydropyridine derivative, nicardipine, in comparison with furosemide given during surgical interventions on 13 hypertensive patients. In another group of 16 surgical patients, a bolus of furosemide 10 mg is given for a control. In hypertensive patients, intravenous nicardipine in doses of 1 to 2 micrograms.kg-1.min-1 produced normotensive state during surgery accompanied by significant diuresis. The extent of diuresis produced by the two agents, nicardipine and furosemide, was similar in urine volume and sodium excretion rate. On the contrary, the fractional excretion of PO4 (FEP) increased from 9.4 +/- 5.5% to 29.8 +/- 10.4% only after nicardipine. Plasma levels of electrolytes (Na, K, Ca, PO4) and parathyroid hormone showed no change during the study in the two groups. Nicardipine induced diuresis and phosphaturia in all hypertensive surgical patients regardless of the levels of creatinine clearance, plasma PO4 and parathyroid hormone. As organic phosphate reabsorption occurs largely in the proximal tubule, increased phosphaturia suggests that the proximal tubule is activated by nicardipine.

Diuretics↗
PubMed1985

[A study on pathogenesis and treatment of normoprolactinemic galactorrhea syndrome].

To investigate the pathogenesis of the normoprolactinemic galactorrhea syndrome, the response of prolactin secretion to TRH administration and the circadian profile of serum prolactin levels were examined in 13 women with galactorrhea whose resting levels of serum prolactin were lower than 25 ng/ml. Bromocriptine (5mg/day) was administered for 30 days and the mid-luteal serum estradiol and progesterone levels, as indicators of luteal function, were also measured before and after the administration. The basal levels of serum prolactin in these patients were significantly higher than those of the control (p less than 0.05), and the response of prolactin secretion also increased significantly at 30, 60, 90 and 120 min. after TRH administration compared to those of the control (p less than 0.005). The circadian profile of serum prolactin showed significantly higher levels from 22 to 8 o'clock compared to the control (p less than 0.05 approximately 0.005). And serum prolactin levels of these patients were higher than 25 ng/ml during the nocturnal period. When bromocriptine was administered, serum prolactin levels of these patients dropped conspicuously, and the nocturnal surges of prolactin also suppressed. Serum estradiol and progesterone levels in the mid-luteal phase normalized apparently due to the administration of bromocriptine (p less than 0.005, p less than 0.005), and galactorrhea also disappeared. These facts suggested that the normoprolactinemic galactorrhea syndrome might be caused by transient occulted hyperprolactinemia, and the treatment with bromocriptine was useful not only in suppressing galactorrhea but also in improving the luteal function in these patients.

Bromocriptine↗
PubMed1977

Glycogen estimation by a rapid enzymic method in very small samples of human endometrium: glycogen content in the endometrium of infertile patients during the menstrual cycle.

An enzymic method using alpha-glucosidases was adapted for measuring glycogen in very small samples (3 mg) of human endometrium. The method is useful as a clinical test of the physiologic function of human endometrium. The glycogen content of the endometrium of normal and infertile patients was measured during the menstrual cycle. The maximal content in both groups was observed between the 16th and 23rd days of the cycle, but the glycogen content of the infertile group was significantly lower (P less than 0.005). These results confirm the reports of others. Endometrial glycogen and urinary pregnanediol levels in 32 infertile patients were measured on day 7 after ovulation. The glycogen content of the endometrium of 21 of these patients, who showed normal excretion of urinary pregnanediol (greater than or equal to 2 mg/day), was significantly higher than that of the other 11 patients who showed low excretion of urinary pregnanediol (less than 2 mg/day) (P less than 0.005). This finding suggests that there is a high correlation between the function of the corpus luteum and endometrial glycogen deposition.

Clinical Enzyme Tests↗