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Biomedical subjects

I T Jones

Publications and source records attributed to I T Jones.

12 recordsLinked to original sources
PubMed2005

Evaluation of the use of computed tomography versus conventional orthogonal X-ray simulation in the treatment of rectal cancer.

The aim of this study is to compare and contrast the treatment fields designed using CT versus conventional orthogonal X-ray simulation in the treatment of patients with rectal cancer given preoperative chemotherapy and radiotherapy. Nine patients participated in this study. The coverage of treatment fields, the volume of treatment fields, and the position of the anorectal junction in relation to the inferior border of the obturator foramen as the delineator of the pelvic floor were evaluated in each patient using CT and conventional orthogonal X-ray simulation. The results demonstrated undercoverage of the anterior border of the lateral fields of up to 2.5 cm in seven of nine patients when conventional orthogonal X-ray simulation was compared to CT simulation. In addition, the inferior border of the obturator foramen proved to be a poor delineator of the pelvic floor with the anorectal junction situated up to 2 cm superiorly in seven of nine patients. In conclusion, CT simulation is superior to conventional orthogonal X-ray simulation when designing treatment fields for patients with rectal cancer.

Humans↗
PubMed2001

Profuse familial adenomatous polyposis with an adenomatous polyposis coli exon 3 mutation.

The attenuated form of familial adenomatous polyposis coli (AAPC) is associated with mutations in the adenomatous polyposis coli (APC) gene which cluster in the 5' region of the gene. It has been proposed that a 'genotype-phenotype boundary' exists at codons 159-163, and mutations that are 5' of this boundary will produce AAPC. Herein we document a three-generation family with an exon 3 mutation well to the 5' side of the proposed boundary, in which two affected individuals have had, in their 40s, a profuse form of familial adenomatous polyposis coli. We conclude that the codon 159-163 'boundary' is indicative rather than definitive. These two patients also had postoperative intra-abdominal adhesions, severely so in one.

Adenomatous Polyposis Coli↗
PubMed1989

Colonic volvulus. Etiology and management.

Colonic volvulus accounts for 1-7% of cases of large bowel obstruction in the United States and Western Europe. It is, however, a much commoner condition in parts of Africa, South Asia and South America. Volvulus is thought to be an idiopathic condition, probably with an anatomical basis, particularly in cecal volvulus. Some cases are, however, secondary to a known condition such as Chagas' disease. The sigmoid colon is involved in 65-80% of cases and the right colon in 15-30%. Transverse colon and splenic flexure volvulus are rare. Emergency surgery has in the past been associated with a high mortality. Nonoperative, tube decompression of sigmoid volvulus has been the single most important advance in the management of the condition--this has allowed surgery to be deferred to an elective schedule and performed on a fitter patient with a prepared bowel. Emergency surgery is still required for a minority of patients--those in whom tube decompression is unsuccessful; in those with signs of gangrenous bowel and patients with volvulus proximal to the sigmoid. When the bowel is not viable, resection is mandatory. In patients with a viable colon, there are several options. Sigmoid resection and colostomy for sigmoid volvulus and detorsion, cecopexy and tube cecostomy as a combined procedure for cecal volvulus are the usually recommended procedures.

Colonic Diseases↗
PubMed1988

Small colorectal polyps. Are they worth treating?

The histology of small (less than or equal to 0.5 cm.) colorectal polyps removed during total colonoscopy in 303 patients was reviewed to determine their clinical significance. There were 178 male patients and 125 females, with a median age of 64 years (range, 26 to 97 years). A total of 766 polyps were treated, 60 percent being adenomatous and 22 percent hyperplastic. Hyperplastic polyps were more common in the rectum (71 percent) while adenomas were more common in the colon (63 percent). Hyperplastic polyps in the colon were associated with adenomas in 75 percent of cases and hyperplastic rectal polyps were associated with proximal adenomas in 63 percent. There were six mixed hyperplastic/adenomatous polyps. Of the 458 adenomas, 449 were tubular, eight were tubulovillous, and one was villous. Moderate dysplasia was noted in 23 (5 percent) and severe dysplasia in four (0.9 percent). There were associated large adenomas in 84 patients. Small colonic polyps are usually adenomatous and should be destroyed. Biopsy may be important if no other neoplasm has been identified. Small rectal polyps are usually hyperplastic but may be associated with proximal adenomas. Because of the uncertain significance of hyperplastic polyps they should also be treated, and are a relative indication for total colonoscopy.

Adult↗
PubMed1987

The use of transanal rectal advancement flaps in the management of fistulas involving the anorectum.

Between 1981 and 1986, transanal rectal advancement flaps were employed in the surgical management of 39 anorectal fistulas at the Cleveland Clinic. Included were 23 low rectovaginal, 12 fistulas-in-ano and, four rectourethral fistulas. Nineteen fistulas occurred in patients with Crohn's disease while the other 20 included 11 due to obstetric or surgical injury. This technique has become the Clinic's standard management for low rectovaginal fistulas but is reserved for complex fistulas-in-ano. Active proctitis or malignancy are contraindications to the procedure. Surgery requires elevation of a broad-based rectal flap, curettage of the tract, and advancement and primary suture of the flap over the internal opening. Fistulas were eradicated in 27 cases (69.2 percent) including 11 of 19 due to Crohn's disease (57.9 percent) and 16 of the 20 (80.0 percent) from other causes (mean follow-up, 25 months). Rectovaginal fistulas healed in 60.0 percent of those with Crohn's disease compared with 76.9 percent of those due to other causes. Complex fistulas-in-ano in Crohn's disease did less well. Only two of six of these fistulas healed. Temporary stomal diversion was used on nine occasions and a successful outcome was achieved in only four, indicative of the greater complexity of these cases. It is concluded that the transanal rectal advancement flap can be an effective method of repair for fistulas of the anorectal region including selected cases due to Crohn's disease.

Adult↗
PubMed1987

Definitive management of rectal cancer by contact (endocavitary) irradiation.

In a retrospective review, 62 patients treated for rectal cancer by contact (endocavitary) irradiation at The Cleveland Clinic Foundation were analyzed. This treatment modality delivers high dose, low penetration irradiation to a rectal cancer by direct contact of a 50 KV x-ray source through a special proctoscope. Cancers selected for this treatment include small (3 cm or less), mobile tumors without presacral lymphadenopathy that are within reach of digital examination and are well- or moderately well-differentiated adenocarcinomas. Between 1973 and 1984, 62 patients (37 males, 25 females) were treated--46 by contact irradiation alone and 16 by contact irradiation after excisional biopsy. The median tumor dose was 12,000 rads administered in four fractions at monthly intervals. Mean follow-up was 31 months. Fifty-six patients (90 percent) were disease-free at the time of review or death (ten died from unrelated causes). Eleven patients (18 percent) developed local recurrence but eight of these without distant metastases were rendered disease-free by other treatment--six by surgical resection and two by further radiotherapy. Mean time since secondary treatment is 20 months. Three patients are alive with incurable disease and three have died from cancer--in three of these six patients there was no evidence of local disease. Ulcerated tumors developed local recurrence in five of 17 cases (29 percent) while polypoid tumors recurred locally in six cases (14 percent). Morbidity from the treatment was minor in nature. It is suggested that contact (endocavitary) irradiation is effective treatment for carefully selected cases of rectal cancer.

Adenocarcinoma↗
PubMed1987

Rectourethral fistulas in Crohn's disease.

Rectourethral fistula is an uncommon complication of Crohn's disease. When the rectum is apparently spared of active Crohn's disease, repair by an advancement flap of the rectum may be used, with or without temporary fecal diversion. Three such fistulas were reported successfully using this technique.

Adult↗
PubMed1986

Desmoid tumors in familial polyposis coli.

Desmoid tumors are locally invasive, nonmetastasizing fibrous tumors most frequently seen in patients with familial polyposis coli (FPC). Of 325 patients with FPC treated at the Cleveland Clinic, 29 (8.9%) were found to have a total of 36 desmoid tumors. These tumors occur in young patients (mean age: 29.8 years), particularly women (ratio 3:1), and most appeared after previous colectomy (86%). The majority (72% of all desmoids, 90% of patients) were located within the abdomen, specifically within the mesentery of the small intestine. In most cases, attempts at surgical resection were followed by recurrence, and other previous treatments were similarly ineffective. Six of the 29 patients (21%) died from the desmoid and three died from other causes. The recent use of sulindac (Clinoril) has produced some early encouraging results in four patients with these tumors that have proven so difficult to treat in the past.

Abdominal Neoplasms↗
PubMed1983

Ectopic pregnancy after tubal sterilization.

A case of ectopic pregnancy which occurred 10 months after laparoscopic sterilization by the application of a Hulka clip is reported. Although ectopic pregnancy after other forms of tubal sterilization is well recognized, such pregnancies are rare when tubal-occlusion clips are used. The mechanism of pregnancy in this case is discussed.

Adult↗