PubMed Health⌕ Search

Biomedical subjects

I Tóth

Publications and source records attributed to I Tóth.

At least 109 records · Page 6Linked to original sources
PubMed1975

Biotransformation of 4 [4-14C]4-androsteni-3,17-dione by healthy human skin in vitro.

The metabolism of [4-14C]4-androstene-3,17-dione was investigated in vitro with healthy female and male abdominal skin slices. With a reverse isotope dilution method the following androgenically active metabolites were isolated and identified:5 alpha-androstane-3,17-dione, androsterone, epiandrosterone, testosterone and 5 alpha-dihydrotestosterone. The quantitative relations of the metabolites produced revealed that the main direction of the metabolism of 4-androstene-3,17-dione in the healthy female and male abdominal skin segments is the 5 alpha-reduction of the delta 4-5 double bond. The other significant pathway is towards the biosynthesis of testosterone and 5 alpha-dihydrotestosterone. The importance of the androgenic steroids formed in the course of the biotransformation of 4-androstene-3, 17-dione in human skin is discussed.

Abdomen↗
PubMed1975

The metabolism of [4-14C]5-androstene-3 beta, 17 beta-diol by normal human skin in vitro.

Healthy female and male abdominal skin slices were incubated with [4-14C]5-androstene-3 beta, 17 beta-diol. With a reverse isotope dilution method the following metabolites were isolated and identified: 5 alpha-androstane-3,17-dione, 4-androstene-3, 17-dione, 5 alpha-dihydrotestosterone, dehydroepiandrosterone, androsterone, testosterone, 7-keto-5-androstene-3beta, 17 beta-diol, 7 alpha-hydroxydehydroepiandrosterone sulphate and 5-androstene-3 beta, 17 beta-diol-3-sulphate. The amounts of the metabolites formed showed that [4-14C]5-androstene-3 beta, 17 beta-diol was metabolized in different ways by healthy female and male abdominal skin slices. In female skin the main direction of metabolism leads to the formation of androgenic steroids, while in male skin the main biosynthetic route is the C7-oxidation of the substrate. The fact that 5-androstene-3beta, 17 beta-diol is transformed to a considerable extent to testosterone and 5 alpha-dihydrotestosterone proves that in human skin 5-androstene-3 beta, 1m beta-diol is a better precursor of the androgenic steroids than dehydroepiandrosterone or 4-androstene-3, 17-dione.

Abdomen↗