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Biomedical subjects

I Tei

Publications and source records attributed to I Tei.

9 recordsLinked to original sources
PubMed1999

[Clinical study of serum S-100 beta protein as marker of brain injury in cardiovascular surgery].

There is no simple and specific marker of brain injury in cardiovascular surgery. S-100 beta protein is a specific protein of the central nervous system. S-100 beta protein detected in spinal fluid and serum is a reflection of brain injury. The aim of this study was to investigate the influence of extracorporeal circulation (ECC) on the brain, with reference to serum S-100 beta protein level and operative factors. Twenty-two patients (12 undergoing coronary artery bypass grafting (CABG), 2 mitral valve replacement, 2 left ventricular aneurysmectomy, 2 grafting of descending thoracic aneurysm, 1 aortic valve replacement (AVR), 1 CABG with AVR, 1 closure of atrial septal defect, 1 aorto-bifemoral and left subclavian artery bypass grafting) without symptomatic neurological complications underwent cardiovascular surgery using ECC. Serum S-100 beta level was measured by enzyme-linked immunosorbent assay before ECC and half an hour after the end of ECC in cardiovascular surgery. Carotid lesions, calcification of the ascending aorta, history of cerebral infarction, and pulsatile or nonpulsatile flow during ECC were evaluated as the operative factors. The correlation of S-100 beta level after ECC with age, duration of ECC and aortic cross clamp time was examined. Serum S-100 beta level was significantly increased after ECC (0.25 +/- 0.48 microgram/l vs. 0.99 +/- 0.64 microgram/l; p < 0.01). Calcification of the ascending aorta was the only significant operative factor that increased S-100 beta level after ECC (calcification 1.35 +/- 0.71 vs. non-calcification 0.68 +/- 0.37 p < 0.01). S-100 beta level after ECC was related to aortic cross clamp time (r = 0.54; p < 0.05, n = 20). It is suggested that brain injury, as reflected by serum S-100 beta protein, is more frequent in cases with calcification of the ascending aorta or a long aortic cross clamp time. It was concluded that serum S-100 beta is a simple potential marker of cerebral injury in cardiovascular surgery with ECC.

Adolescent↗
PubMed1998

[A surgical case of angina pectoris with a severe stenosis of Lt. mid-cerebral artery: the usefulness of the monitoring of cerebral blood flow].

A 64-year-old male patient had two episodes of transient ischemic attack and a cerebral infarction. Cerebral angiography showed 50% stenosis at the junction of left internal carotid artery and 90% stenosis at left mid-cerebral artery (MCA). Coronary angiography showed two vessel disease with arteriosclerotic change and underwent coronary artery bypass grafting. To prevent intraoperative cerebral infarction, we used brain protect solution just before starting ECC, set perfusion flow around 3 l/min/m2, monitored the flow of left MCA using Transcranial Doppler (TCD) and the saturation of left internal jugular vein (SjO2) continuously. PaCO2 was controlled around 45 mmHg. TCD showed good pulsatile flow, and SjO2 was kept over 60%. The patient recovered consciousness 2 hours after operation in the intensive care unit without paresthesia. We thought the number of open-heart cases with cerebrovascular disease increased, and pulsatile low of ECC by intraaortic balloon pumping and the monitoring of SjO2 are useful for the cases.

Angina Pectoris↗
PubMed1994

[A successful repair of ventricular septal defect and patient ductus arteriosus associated with pulmonary hypertension in an infant with left lung agenesis].

We report the first case of successful repair of ventricular septal defect (VSD) and patent ductus arteriosus (PDA) associated with pulmonary hypertension in an infant with left lung agenesis. A 70-days-old infant was referred to our hospital with the diagnosis of congenital heart disease and abnormalities of the left lung. Two-dimensional echocardiogram showed ventricular septal defect and patent ductus arteriosus associated with pulmonary hypertension. Computed tomogram of the chest and bronchogram confirmed agenesis of the left lung. The operation was performed at age 114 days with the body weight 4333 g. VSD was closed with the patch and PDA was ligated under cardiopulmonary bypass. Postoperative course was uneventful. Cardiac catheterization, 50 days after operation, revealed normal pulmonary arterial pressure and good cardiac function. Agenesis of the lung is a rare condition and often associated with congenital abnormalities of the skeletal, gastrointestinal, genitourinary and cardiovascular system. As the prognosis is poor especially in those with congenital heart disease, the cardiac surgery is mandatory for the patient to survive.

Abnormalities, Multiple↗
PubMed1994

[Clinical experience of autotransfusion of shed mediastinal blood using a new device].

Autotransfusion of shed mediastinal blood is expected to be adopted as a technique to reduce transfusion thus preventing various complications such as hepatitis, AIDS, and GVHD. We report the usefulness and problems of a new device-Solcotrans Plus, which only requires connection to wall suction. This device consists of three parts: suction, reservoir bag, and filter for autoinfusion. After setting the suction and reservoir bag primed with anticoagulant, ACD or heparin, and connecting the unit to a wall suction, we performed autotransfusion of shed blood through the filtration component in ICU after operation. Postoperative hematological and biochemical examinations revealed no complications or adverse effects of autotransfusion. This device is available, simple to handle, and is useful for returning shed blood. We believe that this device will be effective for non-blood open heart surgery or reduction of transfusion.

Aged↗
PubMed1984

Increase of transferrin receptors in regenerating rat liver cells after partial hepatectomy.

The change of transferrin receptors in regenerating rat liver cells after partial hepatectomy was demonstrated. The binding of 125I-labeled transferrin to the cells began to increase after 24 h of partial hepatectomy and reached about double that of the non-operated normal rat liver cells. A Scatchard analysis of binding parameters showed 1.62 X 10(5) (Ka: 1.04 X 10(7) M-1) in normal cells and 3.36 X 10(5) (Ka: 1.23 X 10(7) M-1) in regenerating cells. This reflected on increase of transferrin receptor number and little change occurred in the binding affinity between transferrin and its surface receptor.

Animals↗
PubMed1983

Detection of the changes in protein distribution in rat serum after partial hepatectomy using two-dimensional electrophoresis under non-denaturing conditions.

The changes in rat serum protein distribution after partial hepatectomy were examined using two-dimensional electrophoresis, utilizing isoelectric focusing in polyacrylamide gel in the first dimension and pore gradient polyacrylamide gel electrophoresis in the second dimension. Drastic decreases in amount of protein were observed at more than twenty spot positions, and drastic increases in amount or newly appeared proteins were observed at eight spot positions. The amounts of albumin, immunoglobulin M and alpha 2-macroglobulin did not change relatively after hepatectomy. The time course of the changes was examined using a densitometer, and it was observed that almost all the serum proteins changed drastically at 24 h after hepatectomy.

Animals↗
PubMed1978

Electron microscopic observation of scirrhous carcinoma of the stomach.

Electron microscopic findings obtained from seven scirrhous carcinomas of the stomach were analyzed dividing each carcinoma into superficial, deep, and peripheral parts. Proliferation of collagen fibrils, disappearance of plasma membranes, and extracellular release of cell organellae of cancer cells were considered to be peculiar findings to this type of cancer. These phenomena were observed frequently at the deep part of the cancer, but rarely at the peripheral and superficial parts. Replacement of damaged cells by the proliferated collagen fibrils at the central area of the cancer and disconnection of cancer cells from scirrhous lesion at the peripheral part were considered to contribute to the biological behaviour of this carcinoma.

Adenocarcinoma↗