Biomedical subjects

I Tischoff

Publications and source records attributed to I Tischoff.

3 recordsLinked to original sources

PubMed2007

[Role of epigenetics in the carcinogenesis of head and neck carcinomas - possible new targeted therapy?].

In search of new targeted therapies for squamous cell carcinoma of the head neck (HNSCC), a better understanding of the carcinogenesis is of outmost importance. Recent studies show that not only genetic but also epigenetic alterations initiate the multistep process of tumordevelopment. Epigenetic changes lead to altered gene expression without alterations of the DNA sequence. The best characterized epigenetic change is the methylation of the promoter region of genes, especially of tumorsuppressor genes. The methylation of the promoter region blocks the promoter and therefore represses transcription. The loss of the gene products of tumorsuppressor genes leads to increased proliferation and decreased apoptosis. Methylation of tumorsuppressor genes was shown in precancerous lesions of HNSCC, which emphasizes the importance of methylation as an early biomarker. Several studies of tumor cell cultures show reactivated expression of proteins and as a result reduction of proliferation and induction of apoptosis after treatment with demethylating agentens. This presents a very promising new option for a targeted therapy.

Antimetabolites, Antineoplastic↗

PubMed2006

[Histopathological faults and their importance for staging and therapy].

There is a variety of mistake sources of histopathological workup of biopsies and resection specimen. Among those are the incorrect or missing transmission of clinical findings and data. The most critical opportunities for producing mistakes are the histopathological examination, diagnosis and classifications. Many of these mistakes bear the potential to induce a wrong therapy. Generally, the use of forms, check lists and standardized diagnosis sheets may help to reduce the mistake rates. Comparison of own data with quality indicators enables pathologists to validate their own findings.

Adenocarcinoma↗

PubMed2004

[Tumor classifications].

The correct use of tumor classifications is one of the key elements of adequate oncological treatment. Tumor classifications comprise: localization, typing, grading staging and stage grouping, classification after neoadjuvant radio(chemo)therapy, TNM classification and R classification. For easier identification and better documentation it is advisable to have a summary of tumor classifications at the end of each tumor concerning pathology report. Experience in clinical use has shown that classification may be incomplete or inadequately used. Not infrequently they are reported in a way which is open for misinterpretation. Some possible mistakes and misuse of tumor classifications are discussed. Users, among which are clinicians and pathologists, have to bear in mind the limitations of tumor classifications. These are for example reflected by the difficulty to classify single tumor entities in a correct way.

Female↗